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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OPA1
Full Name:
Dynamin-like 120 kDa protein, mitochondrial
Alias:
Dynamin-like 120 kDa protein, mitochondrial; KIAA0567
Type:
G protein, monomeric (non-Rab), mitochondrial,
Mass (Da):
111658
Number AA:
960
UniProt ID:
O60313
International Prot ID:
IPI00006721
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030425
GO:0016021
GO:0030061
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0019896
GO:0007007
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
Q
S
L
V
K
H
S
S
G
I
K
G
S
L
P
Site 2
S27
H
S
S
G
I
K
G
S
L
P
L
Q
K
L
H
Site 3
S39
K
L
H
L
V
S
R
S
I
Y
H
S
H
H
P
Site 4
Y41
H
L
V
S
R
S
I
Y
H
S
H
H
P
T
L
Site 5
S43
V
S
R
S
I
Y
H
S
H
H
P
T
L
K
L
Site 6
T47
I
Y
H
S
H
H
P
T
L
K
L
Q
R
P
Q
Site 7
T57
L
Q
R
P
Q
L
R
T
S
F
Q
Q
F
S
S
Site 8
S58
Q
R
P
Q
L
R
T
S
F
Q
Q
F
S
S
L
Site 9
S64
T
S
F
Q
Q
F
S
S
L
T
N
L
P
L
R
Site 10
S76
P
L
R
K
L
K
F
S
P
I
K
Y
G
Y
Q
Site 11
Y82
F
S
P
I
K
Y
G
Y
Q
P
R
R
N
F
W
Site 12
T95
F
W
P
A
R
L
A
T
R
L
L
K
L
R
Y
Site 13
T114
S
A
V
G
G
G
Y
T
A
K
K
T
F
D
Q
Site 14
Y146
I
V
W
E
I
D
E
Y
I
D
F
E
K
I
R
Site 15
S158
K
I
R
K
A
L
P
S
S
E
D
L
V
K
L
Site 16
S159
I
R
K
A
L
P
S
S
E
D
L
V
K
L
A
Site 17
T184
S
L
L
K
D
F
F
T
S
G
S
P
E
E
T
Site 18
S187
K
D
F
F
T
S
G
S
P
E
E
T
A
F
R
Site 19
T191
T
S
G
S
P
E
E
T
A
F
R
A
T
D
R
Site 20
T196
E
E
T
A
F
R
A
T
D
R
G
S
E
S
D
Site 21
S200
F
R
A
T
D
R
G
S
E
S
D
K
H
F
R
Site 22
S202
A
T
D
R
G
S
E
S
D
K
H
F
R
K
V
Site 23
S210
D
K
H
F
R
K
V
S
D
K
E
K
I
D
Q
Site 24
T225
L
Q
E
E
L
L
H
T
Q
L
K
Y
Q
R
I
Site 25
Y229
L
L
H
T
Q
L
K
Y
Q
R
I
L
E
R
L
Site 26
S263
H
H
R
K
L
K
K
S
L
I
D
M
Y
S
E
Site 27
Y268
K
K
S
L
I
D
M
Y
S
E
V
L
D
V
L
Site 28
S276
S
E
V
L
D
V
L
S
D
Y
D
A
S
Y
N
Site 29
Y278
V
L
D
V
L
S
D
Y
D
A
S
Y
N
T
Q
Site 30
S281
V
L
S
D
Y
D
A
S
Y
N
T
Q
D
H
L
Site 31
Y282
L
S
D
Y
D
A
S
Y
N
T
Q
D
H
L
P
Site 32
T302
G
D
Q
S
A
G
K
T
S
V
L
E
M
I
A
Site 33
S318
A
R
I
F
P
R
G
S
G
E
M
M
T
R
S
Site 34
T323
R
G
S
G
E
M
M
T
R
S
P
V
K
V
T
Site 35
S325
S
G
E
M
M
T
R
S
P
V
K
V
T
L
S
Site 36
S332
S
P
V
K
V
T
L
S
E
G
P
H
H
V
A
Site 37
S344
H
V
A
L
F
K
D
S
S
R
E
F
D
L
T
Site 38
S345
V
A
L
F
K
D
S
S
R
E
F
D
L
T
K
Site 39
T351
S
S
R
E
F
D
L
T
K
E
E
D
L
A
A
Site 40
T376
K
N
V
K
E
G
C
T
V
S
P
E
T
I
S
Site 41
S378
V
K
E
G
C
T
V
S
P
E
T
I
S
L
N
Site 42
S383
T
V
S
P
E
T
I
S
L
N
V
K
G
P
G
Site 43
T405
D
L
P
G
V
I
N
T
V
T
S
G
M
A
P
Site 44
T414
T
S
G
M
A
P
D
T
K
E
T
I
F
S
I
Site 45
S420
D
T
K
E
T
I
F
S
I
S
K
A
Y
M
Q
Site 46
S453
S
I
V
T
D
L
V
S
Q
M
D
P
H
G
R
Site 47
T462
M
D
P
H
G
R
R
T
I
F
V
L
T
K
V
Site 48
S478
L
A
E
K
N
V
A
S
P
S
R
I
Q
Q
I
Site 49
S511
G
K
G
N
S
S
E
S
I
E
A
I
R
E
Y
Site 50
Y518
S
I
E
A
I
R
E
Y
E
E
E
F
F
Q
N
Site 51
S559
F
W
K
M
V
R
E
S
V
E
Q
Q
A
D
S
Site 52
S566
S
V
E
Q
Q
A
D
S
F
K
A
T
R
F
N
Site 53
Y582
E
T
E
W
K
N
N
Y
P
R
L
R
E
L
D
Site 54
S609
L
D
E
V
I
S
L
S
Q
V
T
P
K
H
W
Site 55
T612
V
I
S
L
S
Q
V
T
P
K
H
W
E
E
I
Site 56
S623
W
E
E
I
L
Q
Q
S
L
W
E
R
V
S
T
Site 57
S629
Q
S
L
W
E
R
V
S
T
H
V
I
E
N
I
Site 58
T630
S
L
W
E
R
V
S
T
H
V
I
E
N
I
Y
Site 59
T648
A
Q
T
M
N
S
G
T
F
N
T
T
V
D
I
Site 60
T652
N
S
G
T
F
N
T
T
V
D
I
K
L
K
Q
Site 61
S682
E
T
L
Q
E
E
F
S
R
F
M
T
E
P
K
Site 62
T686
E
E
F
S
R
F
M
T
E
P
K
G
K
E
H
Site 63
S708
K
E
A
V
K
E
E
S
I
K
R
H
K
W
N
Site 64
S734
H
N
A
L
E
D
R
S
I
S
D
K
Q
Q
W
Site 65
S736
A
L
E
D
R
S
I
S
D
K
Q
Q
W
D
A
Site 66
Y746
Q
Q
W
D
A
A
I
Y
F
M
E
E
A
L
Q
Site 67
Y808
C
N
E
E
H
P
A
Y
L
A
S
D
E
I
T
Site 68
S811
E
H
P
A
Y
L
A
S
D
E
I
T
T
V
R
Site 69
T815
Y
L
A
S
D
E
I
T
T
V
R
K
N
L
E
Site 70
T816
L
A
S
D
E
I
T
T
V
R
K
N
L
E
S
Site 71
S823
T
V
R
K
N
L
E
S
R
G
V
E
V
D
P
Site 72
S831
R
G
V
E
V
D
P
S
L
I
K
D
T
W
H
Site 73
Y841
K
D
T
W
H
Q
V
Y
R
R
H
F
L
K
T
Site 74
T848
Y
R
R
H
F
L
K
T
A
L
N
H
C
N
L
Site 75
Y861
N
L
C
R
R
G
F
Y
Y
Y
Q
R
H
F
V
Site 76
Y862
L
C
R
R
G
F
Y
Y
Y
Q
R
H
F
V
D
Site 77
Y863
C
R
R
G
F
Y
Y
Y
Q
R
H
F
V
D
S
Site 78
T890
I
Q
R
M
L
A
I
T
A
N
T
L
R
Q
Q
Site 79
T901
L
R
Q
Q
L
T
N
T
E
V
R
R
L
E
K
Site 80
T929
E
K
K
I
K
L
L
T
G
K
R
V
Q
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation