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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AQR
Full Name:
Intron-binding protein aquarius
Alias:
Intron-binding protein of 160 kDa
Type:
Mass (Da):
171277
Number AA:
1485
UniProt ID:
O60306
International Prot ID:
IPI00297572
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
P
K
K
I
V
A
P
T
V
S
Q
I
N
A
E
Site 2
S16
K
I
V
A
P
T
V
S
Q
I
N
A
E
F
V
Site 3
Y30
V
T
Q
L
A
C
K
Y
W
A
P
H
I
K
K
Site 4
S39
A
P
H
I
K
K
K
S
P
F
D
I
K
V
I
Site 5
Y50
I
K
V
I
E
D
I
Y
E
K
E
I
V
K
S
Site 6
Y76
F
S
Q
Y
L
E
N
Y
L
W
M
N
Y
S
P
Site 7
Y81
E
N
Y
L
W
M
N
Y
S
P
E
V
S
S
K
Site 8
S82
N
Y
L
W
M
N
Y
S
P
E
V
S
S
K
A
Site 9
S86
M
N
Y
S
P
E
V
S
S
K
A
Y
L
M
S
Site 10
S87
N
Y
S
P
E
V
S
S
K
A
Y
L
M
S
I
Site 11
T190
L
E
L
E
L
K
K
T
P
K
L
R
K
F
W
Site 12
Y216
P
E
A
R
E
Q
A
Y
Q
E
R
R
F
L
S
Site 13
S223
Y
Q
E
R
R
F
L
S
Q
L
I
Q
K
F
I
Site 14
S239
V
L
K
S
V
P
L
S
E
P
V
T
M
D
K
Site 15
T243
V
P
L
S
E
P
V
T
M
D
K
V
H
Y
C
Site 16
Y249
V
T
M
D
K
V
H
Y
C
E
R
F
I
E
L
Site 17
T272
P
T
R
R
W
F
N
T
I
L
D
D
S
H
L
Site 18
Y284
S
H
L
L
V
H
C
Y
L
S
N
L
V
R
R
Site 19
S286
L
L
V
H
C
Y
L
S
N
L
V
R
R
E
E
Site 20
S299
E
E
D
G
H
L
F
S
Q
L
L
D
M
L
K
Site 21
T317
G
F
E
I
N
D
Q
T
G
N
A
L
T
E
N
Site 22
Y331
N
E
M
T
T
I
H
Y
D
R
I
T
S
L
Q
Site 23
T335
T
I
H
Y
D
R
I
T
S
L
Q
R
A
A
F
Site 24
S336
I
H
Y
D
R
I
T
S
L
Q
R
A
A
F
A
Site 25
S364
A
E
V
D
T
R
E
S
L
V
K
F
F
G
P
Site 26
S374
K
F
F
G
P
L
S
S
N
T
L
H
Q
V
A
Site 27
T376
F
G
P
L
S
S
N
T
L
H
Q
V
A
S
Y
Site 28
T389
S
Y
L
C
L
L
P
T
L
P
K
N
E
D
T
Site 29
T397
L
P
K
N
E
D
T
T
F
D
K
E
F
L
L
Site 30
S409
F
L
L
E
L
L
V
S
R
H
E
R
R
I
S
Site 31
S416
S
R
H
E
R
R
I
S
Q
I
Q
Q
L
N
Q
Site 32
Y427
Q
L
N
Q
M
P
L
Y
P
T
E
K
I
I
W
Site 33
Y443
E
N
I
V
P
T
E
Y
Y
S
G
E
G
C
L
Site 34
S477
F
N
L
F
R
L
E
S
T
Y
E
I
R
Q
D
Site 35
Y479
L
F
R
L
E
S
T
Y
E
I
R
Q
D
I
E
Site 36
S488
I
R
Q
D
I
E
D
S
V
S
R
M
K
P
W
Site 37
S490
Q
D
I
E
D
S
V
S
R
M
K
P
W
Q
S
Site 38
Y499
M
K
P
W
Q
S
E
Y
G
G
V
V
F
G
G
Site 39
T533
N
I
G
E
N
W
P
T
R
V
R
A
D
V
T
Site 40
T540
T
R
V
R
A
D
V
T
I
N
L
N
V
R
D
Site 41
T570
F
L
I
T
V
R
P
T
K
P
Y
G
T
K
F
Site 42
Y573
T
V
R
P
T
K
P
Y
G
T
K
F
D
R
R
Site 43
S622
R
P
N
L
R
G
E
S
R
T
F
R
V
F
L
Site 44
T624
N
L
R
G
E
S
R
T
F
R
V
F
L
D
P
Site 45
Y634
V
F
L
D
P
N
Q
Y
Q
Q
D
M
T
N
T
Site 46
Y650
Q
N
G
A
E
D
V
Y
E
T
F
N
I
I
M
Site 47
T652
G
A
E
D
V
Y
E
T
F
N
I
I
M
R
R
Site 48
T672
N
F
K
A
V
L
E
T
I
R
N
L
M
N
T
Site 49
Y694
L
H
D
I
I
L
G
Y
G
D
P
S
S
A
H
Site 50
S698
I
L
G
Y
G
D
P
S
S
A
H
Y
S
K
M
Site 51
S699
L
G
Y
G
D
P
S
S
A
H
Y
S
K
M
P
Site 52
S703
D
P
S
S
A
H
Y
S
K
M
P
N
Q
I
A
Site 53
S720
D
F
N
D
T
F
L
S
I
E
H
L
K
A
S
Site 54
S727
S
I
E
H
L
K
A
S
F
P
G
H
N
V
K
Site 55
T736
P
G
H
N
V
K
V
T
V
E
D
P
A
L
Q
Site 56
T750
Q
I
P
P
F
R
I
T
F
P
V
R
S
G
K
Site 57
T771
A
D
V
E
D
E
D
T
E
E
A
K
T
L
I
Site 58
T776
E
D
T
E
E
A
K
T
L
I
V
E
P
H
V
Site 59
Y790
V
I
P
N
R
G
P
Y
P
Y
N
Q
P
K
R
Site 60
Y792
P
N
R
G
P
Y
P
Y
N
Q
P
K
R
N
T
Site 61
T853
E
Q
R
T
L
I
V
T
H
S
N
Q
A
L
N
Site 62
S855
R
T
L
I
V
T
H
S
N
Q
A
L
N
Q
L
Site 63
T888
H
G
E
E
E
L
E
T
E
K
D
F
S
R
Y
Site 64
S893
L
E
T
E
K
D
F
S
R
Y
G
R
V
N
Y
Site 65
Y895
T
E
K
D
F
S
R
Y
G
R
V
N
Y
V
L
Site 66
Y900
S
R
Y
G
R
V
N
Y
V
L
A
R
R
I
E
Site 67
S918
E
V
K
R
L
Q
K
S
L
G
V
P
G
D
A
Site 68
S926
L
G
V
P
G
D
A
S
Y
T
C
E
T
A
G
Site 69
Y927
G
V
P
G
D
A
S
Y
T
C
E
T
A
G
Y
Site 70
Y934
Y
T
C
E
T
A
G
Y
F
F
L
Y
Q
V
M
Site 71
Y938
T
A
G
Y
F
F
L
Y
Q
V
M
S
R
W
E
Site 72
S942
F
F
L
Y
Q
V
M
S
R
W
E
E
Y
I
S
Site 73
Y947
V
M
S
R
W
E
E
Y
I
S
K
V
K
N
K
Site 74
S949
S
R
W
E
E
Y
I
S
K
V
K
N
K
G
S
Site 75
T966
P
D
V
T
E
V
S
T
F
F
P
F
H
E
Y
Site 76
Y973
T
F
F
P
F
H
E
Y
F
A
N
A
P
Q
P
Site 77
S986
Q
P
I
F
K
G
R
S
Y
E
E
D
M
E
I
Site 78
Y987
P
I
F
K
G
R
S
Y
E
E
D
M
E
I
A
Site 79
S1014
Q
L
E
E
F
R
A
S
E
L
L
R
S
G
L
Site 80
S1019
R
A
S
E
L
L
R
S
G
L
D
R
S
K
Y
Site 81
Y1026
S
G
L
D
R
S
K
Y
L
L
V
K
E
A
K
Site 82
Y1112
K
N
M
A
F
Q
K
Y
S
N
M
E
Q
S
L
Site 83
S1142
A
Q
G
R
A
R
A
S
L
C
N
L
Y
N
W
Site 84
Y1147
R
A
S
L
C
N
L
Y
N
W
R
Y
K
N
L
Site 85
Y1151
C
N
L
Y
N
W
R
Y
K
N
L
G
N
L
P
Site 86
S1191
D
F
Q
G
V
G
E
S
E
P
N
P
Y
F
Y
Site 87
Y1196
G
E
S
E
P
N
P
Y
F
Y
Q
N
L
G
E
Site 88
Y1198
S
E
P
N
P
Y
F
Y
Q
N
L
G
E
A
E
Site 89
T1229
D
K
I
S
I
L
T
T
Y
N
G
Q
K
H
L
Site 90
T1258
I
G
R
P
N
K
V
T
T
V
D
R
F
Q
G
Site 91
T1259
G
R
P
N
K
V
T
T
V
D
R
F
Q
G
Q
Site 92
Y1270
F
Q
G
Q
Q
N
D
Y
I
L
L
S
L
V
R
Site 93
T1324
T
P
A
F
S
Q
L
T
A
R
P
L
H
L
H
Site 94
T1335
L
H
L
H
I
I
P
T
E
P
F
P
T
T
R
Site 95
T1340
I
P
T
E
P
F
P
T
T
R
K
N
G
E
R
Site 96
S1349
R
K
N
G
E
R
P
S
H
E
V
Q
I
I
K
Site 97
T1412
E
T
E
E
E
A
M
T
V
Q
A
D
I
I
P
Site 98
S1420
V
Q
A
D
I
I
P
S
P
T
D
T
S
C
R
Site 99
T1424
I
I
P
S
P
T
D
T
S
C
R
Q
E
T
P
Site 100
S1425
I
P
S
P
T
D
T
S
C
R
Q
E
T
P
A
Site 101
T1430
D
T
S
C
R
Q
E
T
P
A
F
Q
T
D
T
Site 102
T1437
T
P
A
F
Q
T
D
T
T
P
S
E
T
G
A
Site 103
T1438
P
A
F
Q
T
D
T
T
P
S
E
T
G
A
T
Site 104
S1440
F
Q
T
D
T
T
P
S
E
T
G
A
T
S
T
Site 105
T1445
T
P
S
E
T
G
A
T
S
T
P
E
A
I
P
Site 106
T1447
S
E
T
G
A
T
S
T
P
E
A
I
P
A
L
Site 107
T1473
S
A
P
A
E
A
N
T
P
Q
D
A
T
S
A
Site 108
T1478
A
N
T
P
Q
D
A
T
S
A
P
E
E
T
K
Site 109
S1479
N
T
P
Q
D
A
T
S
A
P
E
E
T
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation