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Updated November 2019
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Protein Info
Short Name:
KIAA0556
Full Name:
Uncharacterized protein KIAA0556
Alias:
K0556; LOC23247
Type:
Unknown function
Mass (Da):
180948
Number AA:
1618
UniProt ID:
O60303
International Prot ID:
IPI00030790
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
T
L
R
K
A
E
R
S
W
S
C
S
R
E
K
Site 2
S14
R
K
A
E
R
S
W
S
C
S
R
E
K
K
E
Site 3
S16
A
E
R
S
W
S
C
S
R
E
K
K
E
G
Y
Site 4
T29
G
Y
A
K
D
M
V
T
D
F
D
E
K
H
D
Site 5
Y38
F
D
E
K
H
D
E
Y
L
I
L
L
Q
Q
R
Site 6
S54
R
I
L
K
H
L
K
S
K
D
P
V
Q
L
R
Site 7
S70
E
H
L
E
Q
G
F
S
V
Y
V
N
G
A
N
Site 8
Y72
L
E
Q
G
F
S
V
Y
V
N
G
A
N
S
E
Site 9
S78
V
Y
V
N
G
A
N
S
E
L
K
S
S
P
R
Site 10
S82
G
A
N
S
E
L
K
S
S
P
R
K
A
I
H
Site 11
S83
A
N
S
E
L
K
S
S
P
R
K
A
I
H
S
Site 12
S90
S
P
R
K
A
I
H
S
D
F
S
R
S
A
S
Site 13
S93
K
A
I
H
S
D
F
S
R
S
A
S
H
T
E
Site 14
S97
S
D
F
S
R
S
A
S
H
T
E
G
T
H
D
Site 15
T99
F
S
R
S
A
S
H
T
E
G
T
H
D
Y
G
Site 16
Y105
H
T
E
G
T
H
D
Y
G
R
R
T
L
F
R
Site 17
T109
T
H
D
Y
G
R
R
T
L
F
R
E
A
E
E
Site 18
S121
A
E
E
A
L
R
R
S
S
R
T
A
P
S
K
Site 19
S122
E
E
A
L
R
R
S
S
R
T
A
P
S
K
V
Site 20
T124
A
L
R
R
S
S
R
T
A
P
S
K
V
Q
R
Site 21
S127
R
S
S
R
T
A
P
S
K
V
Q
R
R
G
W
Site 22
S138
R
R
G
W
H
Q
K
S
V
Q
I
R
T
E
A
Site 23
Y157
H
I
E
P
P
V
D
Y
S
D
D
F
E
L
C
Site 24
S158
I
E
P
P
V
D
Y
S
D
D
F
E
L
C
G
Site 25
T168
F
E
L
C
G
D
V
T
L
Q
A
N
N
T
S
Site 26
S185
R
P
Q
E
L
R
R
S
L
E
L
S
V
N
L
Site 27
S189
L
R
R
S
L
E
L
S
V
N
L
Q
R
K
Q
Site 28
S200
Q
R
K
Q
K
D
C
S
S
D
E
Y
D
S
I
Site 29
S201
R
K
Q
K
D
C
S
S
D
E
Y
D
S
I
E
Site 30
Y204
K
D
C
S
S
D
E
Y
D
S
I
E
E
D
I
Site 31
S206
C
S
S
D
E
Y
D
S
I
E
E
D
I
L
S
Site 32
S213
S
I
E
E
D
I
L
S
E
P
E
P
E
D
P
Site 33
S233
P
R
H
D
R
P
P
S
S
G
D
W
T
Q
K
Site 34
S234
R
H
D
R
P
P
S
S
G
D
W
T
Q
K
D
Site 35
T238
P
P
S
S
G
D
W
T
Q
K
D
V
H
G
E
Site 36
T248
D
V
H
G
E
Q
E
T
E
G
R
S
S
P
G
Site 37
S253
Q
E
T
E
G
R
S
S
P
G
P
D
T
L
V
Site 38
T258
R
S
S
P
G
P
D
T
L
V
V
L
E
F
N
Site 39
S268
V
L
E
F
N
P
A
S
K
S
H
K
R
E
R
Site 40
S270
E
F
N
P
A
S
K
S
H
K
R
E
R
N
L
Site 41
S278
H
K
R
E
R
N
L
S
A
K
R
K
D
N
A
Site 42
T298
T
K
P
E
P
N
L
T
P
Q
A
P
A
V
F
Site 43
S313
P
D
Q
E
R
M
C
S
R
P
G
S
R
R
E
Site 44
S317
R
M
C
S
R
P
G
S
R
R
E
R
P
L
S
Site 45
S324
S
R
R
E
R
P
L
S
A
T
R
K
T
L
C
Site 46
T326
R
E
R
P
L
S
A
T
R
K
T
L
C
E
A
Site 47
T329
P
L
S
A
T
R
K
T
L
C
E
A
E
Y
P
Site 48
Y335
K
T
L
C
E
A
E
Y
P
E
E
D
A
S
A
Site 49
S341
E
Y
P
E
E
D
A
S
A
V
L
Q
A
I
Q
Site 50
S368
R
K
A
E
Q
P
A
S
P
L
Q
D
A
E
G
Site 51
S383
P
P
A
K
P
W
T
S
L
L
E
E
K
E
E
Site 52
T391
L
L
E
E
K
E
E
T
L
E
L
L
P
I
T
Site 53
T403
P
I
T
T
A
T
T
T
Q
E
P
A
G
A
A
Site 54
S443
K
V
L
Q
A
V
E
S
D
S
A
H
L
G
R
Site 55
S453
A
H
L
G
R
V
V
S
P
T
K
E
Q
V
S
Site 56
T455
L
G
R
V
V
S
P
T
K
E
Q
V
S
D
T
Site 57
S460
S
P
T
K
E
Q
V
S
D
T
E
D
K
Q
R
Site 58
T462
T
K
E
Q
V
S
D
T
E
D
K
Q
R
M
R
Site 59
T506
E
F
F
D
L
N
D
T
K
L
Y
V
S
P
H
Site 60
Y509
D
L
N
D
T
K
L
Y
V
S
P
H
D
V
D
Site 61
S511
N
D
T
K
L
Y
V
S
P
H
D
V
D
I
R
Site 62
T520
H
D
V
D
I
R
N
T
A
T
P
G
E
L
G
Site 63
T522
V
D
I
R
N
T
A
T
P
G
E
L
G
R
L
Site 64
S540
N
L
A
G
K
K
D
S
S
P
W
T
C
P
F
Site 65
S541
L
A
G
K
K
D
S
S
P
W
T
C
P
F
H
Site 66
T544
K
K
D
S
S
P
W
T
C
P
F
H
P
P
L
Site 67
Y576
A
K
I
K
V
R
N
Y
W
T
A
D
G
D
L
Site 68
Y593
G
A
K
N
V
K
L
Y
V
N
R
N
L
I
F
Site 69
S616
R
E
A
P
A
D
H
S
I
L
V
D
Q
K
N
Site 70
S626
V
D
Q
K
N
E
K
S
E
Q
L
E
E
A
M
Site 71
T643
H
S
E
E
S
K
G
T
H
E
M
A
G
A
S
Site 72
S660
K
E
L
G
L
G
C
S
P
P
A
E
T
L
A
Site 73
T665
G
C
S
P
P
A
E
T
L
A
D
A
K
L
S
Site 74
S673
L
A
D
A
K
L
S
S
Q
G
N
V
S
G
K
Site 75
S678
L
S
S
Q
G
N
V
S
G
K
R
K
N
S
T
Site 76
S684
V
S
G
K
R
K
N
S
T
N
C
R
K
D
S
Site 77
T685
S
G
K
R
K
N
S
T
N
C
R
K
D
S
L
Site 78
S691
S
T
N
C
R
K
D
S
L
S
Q
L
E
E
Y
Site 79
S693
N
C
R
K
D
S
L
S
Q
L
E
E
Y
L
R
Site 80
Y698
S
L
S
Q
L
E
E
Y
L
R
L
S
A
V
P
Site 81
T706
L
R
L
S
A
V
P
T
S
M
G
D
M
P
S
Site 82
S707
R
L
S
A
V
P
T
S
M
G
D
M
P
S
A
Site 83
S713
T
S
M
G
D
M
P
S
A
P
A
T
S
P
P
Site 84
T717
D
M
P
S
A
P
A
T
S
P
P
V
K
C
P
Site 85
S718
M
P
S
A
P
A
T
S
P
P
V
K
C
P
P
Site 86
S731
P
P
V
H
E
E
P
S
L
I
Q
Q
L
E
N
Site 87
T751
I
C
E
P
P
G
K
T
P
S
W
L
Q
P
S
Site 88
S753
E
P
P
G
K
T
P
S
W
L
Q
P
S
P
T
Site 89
S758
T
P
S
W
L
Q
P
S
P
T
G
K
D
R
K
Site 90
T760
S
W
L
Q
P
S
P
T
G
K
D
R
K
Q
G
Site 91
S777
K
P
K
P
L
W
L
S
P
E
K
P
L
A
W
Site 92
S790
A
W
K
G
R
L
P
S
D
D
V
I
G
E
G
Site 93
T816
R
H
E
P
G
W
G
T
S
R
S
V
N
T
K
Site 94
S819
P
G
W
G
T
S
R
S
V
N
T
K
E
R
P
Site 95
T830
K
E
R
P
Q
R
A
T
T
K
V
H
S
D
D
Site 96
T831
E
R
P
Q
R
A
T
T
K
V
H
S
D
D
S
Site 97
S835
R
A
T
T
K
V
H
S
D
D
S
D
I
F
N
Site 98
S838
T
K
V
H
S
D
D
S
D
I
F
N
Q
P
P
Site 99
S852
P
N
R
E
R
P
A
S
G
R
R
G
S
R
K
Site 100
S857
P
A
S
G
R
R
G
S
R
K
D
A
G
S
S
Site 101
S863
G
S
R
K
D
A
G
S
S
S
H
G
D
D
Q
Site 102
S865
R
K
D
A
G
S
S
S
H
G
D
D
Q
P
A
Site 103
S873
H
G
D
D
Q
P
A
S
R
E
D
T
W
S
S
Site 104
T877
Q
P
A
S
R
E
D
T
W
S
S
R
T
P
S
Site 105
S879
A
S
R
E
D
T
W
S
S
R
T
P
S
R
S
Site 106
S880
S
R
E
D
T
W
S
S
R
T
P
S
R
S
R
Site 107
T882
E
D
T
W
S
S
R
T
P
S
R
S
R
W
R
Site 108
S884
T
W
S
S
R
T
P
S
R
S
R
W
R
S
E
Site 109
S886
S
S
R
T
P
S
R
S
R
W
R
S
E
Q
E
Site 110
S890
P
S
R
S
R
W
R
S
E
Q
E
H
T
L
H
Site 111
T895
W
R
S
E
Q
E
H
T
L
H
E
S
W
S
S
Site 112
S899
Q
E
H
T
L
H
E
S
W
S
S
L
S
A
F
Site 113
S901
H
T
L
H
E
S
W
S
S
L
S
A
F
D
R
Site 114
S902
T
L
H
E
S
W
S
S
L
S
A
F
D
R
S
Site 115
S904
H
E
S
W
S
S
L
S
A
F
D
R
S
H
R
Site 116
S909
S
L
S
A
F
D
R
S
H
R
G
R
I
S
N
Site 117
S915
R
S
H
R
G
R
I
S
N
T
E
L
P
G
D
Site 118
T917
H
R
G
R
I
S
N
T
E
L
P
G
D
I
L
Site 119
S932
D
E
L
L
Q
Q
K
S
S
R
H
S
D
L
P
Site 120
S933
E
L
L
Q
Q
K
S
S
R
H
S
D
L
P
P
Site 121
S936
Q
Q
K
S
S
R
H
S
D
L
P
P
S
K
K
Site 122
S941
R
H
S
D
L
P
P
S
K
K
G
E
Q
P
G
Site 123
S950
K
G
E
Q
P
G
L
S
R
G
Q
D
G
Y
S
Site 124
Y956
L
S
R
G
Q
D
G
Y
S
G
E
T
D
A
G
Site 125
S957
S
R
G
Q
D
G
Y
S
G
E
T
D
A
G
G
Site 126
Y990
S
T
W
G
D
R
H
Y
V
G
L
N
G
I
E
Site 127
S1000
L
N
G
I
E
I
F
S
S
K
G
E
P
V
Q
Site 128
S1001
N
G
I
E
I
F
S
S
K
G
E
P
V
Q
I
Site 129
Y1024
D
I
N
I
L
P
A
Y
G
K
D
P
R
V
V
Site 130
T1032
G
K
D
P
R
V
V
T
N
L
I
D
G
V
N
Site 131
T1053
H
V
W
L
A
P
F
T
R
G
R
S
H
S
I
Site 132
S1057
A
P
F
T
R
G
R
S
H
S
I
T
I
D
F
Site 133
S1059
F
T
R
G
R
S
H
S
I
T
I
D
F
T
H
Site 134
T1061
R
G
R
S
H
S
I
T
I
D
F
T
H
P
C
Site 135
Y1078
A
L
I
R
I
W
N
Y
N
K
S
R
I
H
S
Site 136
S1085
Y
N
K
S
R
I
H
S
F
R
G
V
K
D
I
Site 137
S1110
E
G
E
I
A
K
A
S
G
T
L
A
G
A
P
Site 138
T1112
E
I
A
K
A
S
G
T
L
A
G
A
P
E
H
Site 139
S1149
M
F
D
L
D
V
G
S
L
D
S
L
Q
D
E
Site 140
S1152
L
D
V
G
S
L
D
S
L
Q
D
E
E
A
M
Site 141
S1163
E
E
A
M
R
R
P
S
T
A
D
G
E
G
D
Site 142
T1164
E
A
M
R
R
P
S
T
A
D
G
E
G
D
E
Site 143
T1175
E
G
D
E
R
P
F
T
Q
A
G
L
G
A
D
Site 144
S1192
I
P
E
L
E
L
P
S
S
S
P
V
P
Q
V
Site 145
S1193
P
E
L
E
L
P
S
S
S
P
V
P
Q
V
T
Site 146
S1194
E
L
E
L
P
S
S
S
P
V
P
Q
V
T
T
Site 147
T1200
S
S
P
V
P
Q
V
T
T
P
E
P
G
I
Y
Site 148
T1201
S
P
V
P
Q
V
T
T
P
E
P
G
I
Y
H
Site 149
S1251
H
L
H
Q
I
S
A
S
P
R
D
L
N
E
L
Site 150
Y1261
D
L
N
E
L
P
E
Y
S
D
D
S
R
T
L
Site 151
S1262
L
N
E
L
P
E
Y
S
D
D
S
R
T
L
D
Site 152
T1267
E
Y
S
D
D
S
R
T
L
D
K
L
I
D
G
Site 153
T1298
P
G
L
D
H
V
V
T
I
R
L
D
R
A
E
Site 154
S1306
I
R
L
D
R
A
E
S
I
A
G
L
R
F
W
Site 155
Y1315
A
G
L
R
F
W
N
Y
N
K
S
P
E
D
T
Site 156
S1318
R
F
W
N
Y
N
K
S
P
E
D
T
Y
R
G
Site 157
T1322
Y
N
K
S
P
E
D
T
Y
R
G
A
K
I
V
Site 158
Y1323
N
K
S
P
E
D
T
Y
R
G
A
K
I
V
H
Site 159
S1383
A
R
R
L
D
M
R
S
L
E
C
A
S
M
D
Site 160
Y1415
T
S
W
G
D
P
Y
Y
I
G
L
T
G
L
E
Site 161
Y1424
G
L
T
G
L
E
L
Y
D
E
R
G
E
K
I
Site 162
S1434
R
G
E
K
I
P
L
S
E
N
N
I
A
A
F
Site 163
S1447
A
F
P
D
S
V
N
S
L
E
G
V
G
G
D
Site 164
T1457
G
V
G
G
D
V
R
T
P
D
K
L
I
D
Q
Site 165
Y1505
S
M
I
K
L
W
N
Y
A
K
T
P
H
R
G
Site 166
T1508
K
L
W
N
Y
A
K
T
P
H
R
G
V
K
E
Site 167
T1547
I
L
P
T
C
E
P
T
V
P
Y
H
T
I
L
Site 168
Y1550
T
C
E
P
T
V
P
Y
H
T
I
L
F
T
E
Site 169
T1569
R
H
Q
E
K
H
T
T
I
S
N
Q
A
E
D
Site 170
S1596
T
N
A
K
R
K
Q
S
V
V
D
P
A
L
R
Site 171
T1606
D
P
A
L
R
P
K
T
C
I
S
E
K
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation