PhosphoNET

           
Protein Info 
   
Short Name:  SIPA1L3
Full Name:  Signal-induced proliferation-associated 1-like protein 3
Alias:  KIAA0545; SI1L3; signal-induced proliferation-associated 1 like 3; signal-induced proliferation-associated 1-like protein 3
Type:  GTPase activating protein, misc.
Mass (Da):  194610
Number AA:  1781
UniProt ID:  O60292
International Prot ID:  IPI00297254
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005622     Uniprot OncoNet
Molecular Function:  GO:0005096  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0051056     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T31DVLPGPHTGDYAPLG
Site 2Y34PGPHTGDYAPLGFWA
Site 3S45GFWAQNGSMSQPLGE
Site 4S47WAQNGSMSQPLGESP
Site 5S53MSQPLGESPATATAT
Site 6T64ATATATATTRPSPTT
Site 7S68ATATTRPSPTTPAMP
Site 8T71TTRPSPTTPAMPKMG
Site 9S97REALREHSNPSPSQD
Site 10S100LREHSNPSPSQDTDG
Site 11S102EHSNPSPSQDTDGTK
Site 12S116KATKMAHSMRSIQNG
Site 13T127IQNGQPPTSTPASSG
Site 14S128QNGQPPTSTPASSGS
Site 15T129NGQPPTSTPASSGSK
Site 16S132PPTSTPASSGSKAFH
Site 17S133PTSTPASSGSKAFHR
Site 18S135STPASSGSKAFHRLS
Site 19S142SKAFHRLSRRRSKDV
Site 20S146HRLSRRRSKDVEFQD
Site 21S158FQDGWPRSPGRAFLP
Site 22S170FLPLRHRSSSEITLS
Site 23S171LPLRHRSSSEITLSE
Site 24S172PLRHRSSSEITLSEC
Site 25T175HRSSSEITLSECDAE
Site 26S177SSSEITLSECDAEDA
Site 27T193EPRGARHTGALPLFR
Site 28Y202ALPLFREYGSTSSID
Site 29T205LFREYGSTSSIDVQG
Site 30S206FREYGSTSSIDVQGM
Site 31S207REYGSTSSIDVQGMP
Site 32S217VQGMPEQSFFDILNE
Site 33S227DILNEFRSEQPDARG
Site 34S261GGGAKGDSHNGQPAK
Site 35S270NGQPAKDSLLPLQPT
Site 36T296RGLGGGDTVDSSIFR
Site 37S299GGGDTVDSSIFRKLR
Site 38S300GGDTVDSSIFRKLRS
Site 39S307SIFRKLRSSKPEGEA
Site 40S308IFRKLRSSKPEGEAG
Site 41S317PEGEAGRSPGEADEG
Site 42S326GEADEGRSPPEASRP
Site 43S331GRSPPEASRPWVCQK
Site 44S347FAHFDVQSMLFDLNE
Site 45S361EAAANRVSVSQRRNT
Site 46S363AANRVSVSQRRNTTT
Site 47T368SVSQRRNTTTGASAA
Site 48T369VSQRRNTTTGASAAS
Site 49T370SQRRNTTTGASAASA
Site 50S383SAASAMASLTASRAH
Site 51S391LTASRAHSLGGLDPA
Site 52S401GLDPAFTSTEDLNCK
Site 53S420QDLGDDNSNDLLLSC
Site 54S426NSNDLLLSCPHFRNE
Site 55S443GECERNVSFSRASVG
Site 56S445CERNVSFSRASVGSP
Site 57S448NVSFSRASVGSPSSG
Site 58S451FSRASVGSPSSGEGH
Site 59S454ASVGSPSSGEGHLAE
Site 60S465HLAEPALSAYRTNAS
Site 61T469PALSAYRTNASISVL
Site 62S472SAYRTNASISVLEVP
Site 63S474YRTNASISVLEVPKE
Site 64T485VPKEQQRTQSRPRQY
Site 65S487KEQQRTQSRPRQYSI
Site 66S493QSRPRQYSIEHVDLG
Site 67Y504VDLGARYYQDYFVGK
Site 68Y507GARYYQDYFVGKEHA
Site 69Y516VGKEHANYFGVDEKL
Site 70S529KLGPVAVSIKREKLE
Site 71Y545HKEHGPQYQYRIIFR
Site 72Y547EHGPQYQYRIIFRTR
Site 73T553QYRIIFRTRELITLR
Site 74T558FRTRELITLRGSILE
Site 75T568GSILEDATPTATKHG
Site 76T576PTATKHGTGRGLPLK
Site 77Y629KHKVGILYCKAGQSS
Site 78S635LYCKAGQSSEEEMYN
Site 79Y641QSSEEEMYNNEEAGP
Site 80Y669CLKGFTKYAAQLDVK
Site 81T677AAQLDVKTDSTGTHS
Site 82S679QLDVKTDSTGTHSLY
Site 83T680LDVKTDSTGTHSLYT
Site 84S684TDSTGTHSLYTMYQD
Site 85Y686STGTHSLYTMYQDYE
Site 86Y689THSLYTMYQDYEIMF
Site 87Y692LYTMYQDYEIMFHVS
Site 88T705VSTLLPYTPNNRQQL
Site 89T736EPGALPFTPKNIRSH
Site 90T768VCYSMAVTRSKDAPP
Site 91S770YSMAVTRSKDAPPFG
Site 92S782PFGPPIPSGTTFRKS
Site 93T784GPPIPSGTTFRKSDV
Site 94T785PPIPSGTTFRKSDVF
Site 95S789SGTTFRKSDVFRDFL
Site 96Y824ATRTRQEYLKDLAEN
Site 97S834DLAENCVSNTPIDST
Site 98T836AENCVSNTPIDSTGK
Site 99S840VSNTPIDSTGKFNLI
Site 100S848TGKFNLISLTSKKKE
Site 101T857TSKKKEKTKARAGAE
Site 102Y880WRVVAQDYAQGVEID
Site 103T920CGDVIGWTPDSSTLK
Site 104S924IGWTPDSSTLKIFYG
Site 105T925GWTPDSSTLKIFYGR
Site 106Y930SSTLKIFYGRGDHIF
Site 107T959VQRLKVMTSGWETVD
Site 108T964VMTSGWETVDMTLRR
Site 109T968GWETVDMTLRRNGLG
Site 110T986FHVKYDGTVAEVEDY
Site 111Y993TVAEVEDYGFAWQAG
Site 112S1005QAGLRQGSRLVEICK
Site 113T1017ICKVAVVTLTHDQMI
Site 114T1019KVAVVTLTHDQMIDL
Site 115T1045IPPFEDGTPRRGWPE
Site 116T1053PRRGWPETYDMNTSE
Site 117Y1054RRGWPETYDMNTSEP
Site 118T1058PETYDMNTSEPKTEQ
Site 119S1059ETYDMNTSEPKTEQE
Site 120T1063MNTSEPKTEQESITP
Site 121S1067EPKTEQESITPGGRP
Site 122T1069KTEQESITPGGRPPY
Site 123Y1076TPGGRPPYRSNAPWQ
Site 124S1078GGRPPYRSNAPWQWS
Site 125S1085SNAPWQWSGPASHNS
Site 126S1089WQWSGPASHNSLPAS
Site 127S1092SGPASHNSLPASKWA
Site 128S1096SHNSLPASKWATPTT
Site 129T1100LPASKWATPTTPGHA
Site 130T1103SKWATPTTPGHAQSL
Site 131S1109TTPGHAQSLSRPLKQ
Site 132S1111PGHAQSLSRPLKQTP
Site 133T1117LSRPLKQTPIVPFRE
Site 134S1125PIVPFRESQPLHSKR
Site 135S1130RESQPLHSKRPVSFP
Site 136S1135LHSKRPVSFPETPYT
Site 137T1139RPVSFPETPYTVSPA
Site 138Y1141VSFPETPYTVSPAGA
Site 139T1142SFPETPYTVSPAGAD
Site 140S1144PETPYTVSPAGADRV
Site 141Y1154GADRVPPYRQPSGSF
Site 142S1158VPPYRQPSGSFSTPG
Site 143S1160PYRQPSGSFSTPGSA
Site 144S1162RQPSGSFSTPGSATY
Site 145T1163QPSGSFSTPGSATYV
Site 146S1166GSFSTPGSATYVRYK
Site 147Y1169STPGSATYVRYKPSP
Site 148S1175TYVRYKPSPERYTAA
Site 149T1180KPSPERYTAAPHPLL
Site 150S1188AAPHPLLSLDPHFSH
Site 151S1194LSLDPHFSHDGTSSG
Site 152T1198PHFSHDGTSSGDSSS
Site 153S1199HFSHDGTSSGDSSSG
Site 154S1200FSHDGTSSGDSSSGG
Site 155S1203DGTSSGDSSSGGLTS
Site 156S1204GTSSGDSSSGGLTSQ
Site 157S1205TSSGDSSSGGLTSQE
Site 158T1209DSSSGGLTSQESTME
Site 159S1210SSSGGLTSQESTMER
Site 160S1213GGLTSQESTMERQKP
Site 161T1214GLTSQESTMERQKPE
Site 162S1239LSAIAGSSGNKHPSR
Site 163S1254QDAAGKDSPNRHSKG
Site 164S1259KDSPNRHSKGEPQYS
Site 165Y1265HSKGEPQYSSHSSSN
Site 166S1266SKGEPQYSSHSSSNT
Site 167S1267KGEPQYSSHSSSNTL
Site 168S1269EPQYSSHSSSNTLSS
Site 169S1270PQYSSHSSSNTLSSN
Site 170S1271QYSSHSSSNTLSSNA
Site 171T1273SSHSSSNTLSSNASS
Site 172S1275HSSSNTLSSNASSSH
Site 173S1276SSSNTLSSNASSSHS
Site 174S1279NTLSSNASSSHSDDR
Site 175S1280TLSSNASSSHSDDRW
Site 176S1281LSSNASSSHSDDRWF
Site 177S1283SNASSSHSDDRWFDP
Site 178S1302EPEQDPLSKGGSSDS
Site 179S1306DPLSKGGSSDSGIDT
Site 180S1309SKGGSSDSGIDTTLY
Site 181T1313SSDSGIDTTLYTSSP
Site 182T1314SDSGIDTTLYTSSPS
Site 183Y1316SGIDTTLYTSSPSCM
Site 184T1317GIDTTLYTSSPSCMS
Site 185S1319DTTLYTSSPSCMSLA
Site 186S1324TSSPSCMSLAKAPRP
Site 187S1340KPHKPPGSMGLCGGG
Site 188S1364ADRRREVSPAPAVAG
Site 189Y1381KGYRPKLYSSGSSTP
Site 190S1382GYRPKLYSSGSSTPT
Site 191S1383YRPKLYSSGSSTPTG
Site 192S1385PKLYSSGSSTPTGLA
Site 193S1386KLYSSGSSTPTGLAG
Site 194T1387LYSSGSSTPTGLAGG
Site 195T1389SSGSSTPTGLAGGSR
Site 196S1403RDPPRQPSDMGSRVG
Site 197S1407RQPSDMGSRVGYPAQ
Site 198Y1411DMGSRVGYPAQVYKT
Site 199Y1416VGYPAQVYKTASAET
Site 200T1423YKTASAETPRPSQLA
Site 201S1427SAETPRPSQLAQPSP
Site 202S1433PSQLAQPSPFQLSAS
Site 203S1438QPSPFQLSASVPKSF
Site 204S1440SPFQLSASVPKSFFS
Site 205S1444LSASVPKSFFSKQPV
Site 206T1457PVRNKHPTGWKRTEE
Site 207T1462HPTGWKRTEEPPPRP
Site 208S1473PPRPLPFSDPKKQVD
Site 209T1483KKQVDTNTKNVFGQP
Site 210S1495GQPRLRASLRDLRSP
Site 211S1501ASLRDLRSPRKNYKS
Site 212Y1506LRSPRKNYKSTIEDD
Site 213S1508SPRKNYKSTIEDDLK
Site 214T1531GPEQERDTGQSPQKG
Site 215S1534QERDTGQSPQKGLQR
Site 216T1542PQKGLQRTLSDESLC
Site 217S1544KGLQRTLSDESLCSG
Site 218S1547QRTLSDESLCSGRRE
Site 219S1550LSDESLCSGRREPSF
Site 220S1556CSGRREPSFASPAGL
Site 221S1559RREPSFASPAGLEPG
Site 222S1582STCAFPSSTLPARRQ
Site 223S1614SGFPEKKSTISASEL
Site 224T1615GFPEKKSTISASELS
Site 225S1617PEKKSTISASELSLA
Site 226S1619KKSTISASELSLADG
Site 227S1622TISASELSLADGRDR
Site 228S1667YEVQRAVSLFSLNDP
Site 229S1677SLNDPALSPDIPPAH
Site 230S1685PDIPPAHSPVHSHLS
Site 231S1689PAHSPVHSHLSLERG
Site 232S1692SPVHSHLSLERGPPT
Site 233T1699SLERGPPTPRTTPTM
Site 234T1702RGPPTPRTTPTMSEE
Site 235T1703GPPTPRTTPTMSEEP
Site 236T1705PTPRTTPTMSEEPPL
Site 237S1707PRTTPTMSEEPPLDL
Site 238T1715EEPPLDLTGKVYQLE
Site 239S1744QDKVVLQSEVASLRQ
Site 240S1748VLQSEVASLRQNNQR
Site 241S1760NQRLQEESQAASEQL
Site 242S1764QEESQAASEQLRKFA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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