KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIF5C
Full Name:
Kinesin heavy chain isoform 5C
Alias:
Kinesin heavy chain 5C; Kinesin heavy chain neuron-specific 2; KINN; NKHC; NKHC2; NKHC-2
Type:
Kinesin complex, Microtubule protein
Mass (Da):
109495
Number AA:
957
UniProt ID:
O60282
International Prot ID:
IPI00028561
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005871
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003777
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
P
K
F
K
G
D
E
T
V
V
I
G
Q
G
K
Site 2
Y85
Y
N
G
T
I
F
A
Y
G
Q
T
S
S
G
K
Site 3
T93
G
Q
T
S
S
G
K
T
H
T
M
E
G
K
L
Site 4
T95
T
S
S
G
K
T
H
T
M
E
G
K
L
H
D
Site 5
Y121
H
D
I
F
D
H
I
Y
S
M
D
E
N
L
E
Site 6
Y135
E
F
H
I
K
V
S
Y
F
E
I
Y
L
D
K
Site 7
Y139
K
V
S
Y
F
E
I
Y
L
D
K
I
R
D
L
Site 8
T152
D
L
L
D
V
S
K
T
N
L
A
V
H
E
D
Site 9
Y165
E
D
K
N
R
V
P
Y
V
K
G
C
T
E
R
Site 10
S175
G
C
T
E
R
F
V
S
S
P
E
E
V
M
D
Site 11
S176
C
T
E
R
F
V
S
S
P
E
E
V
M
D
V
Site 12
T196
A
N
R
H
V
A
V
T
N
M
N
E
H
S
S
Site 13
S202
V
T
N
M
N
E
H
S
S
R
S
H
S
I
F
Site 14
S203
T
N
M
N
E
H
S
S
R
S
H
S
I
F
L
Site 15
S205
M
N
E
H
S
S
R
S
H
S
I
F
L
I
N
Site 16
S207
E
H
S
S
R
S
H
S
I
F
L
I
N
I
K
Site 17
T220
I
K
Q
E
N
V
E
T
E
K
K
L
S
G
K
Site 18
S225
V
E
T
E
K
K
L
S
G
K
L
Y
L
V
D
Site 19
S236
Y
L
V
D
L
A
G
S
E
K
V
S
K
T
G
Site 20
S240
L
A
G
S
E
K
V
S
K
T
G
A
E
G
A
Site 21
S258
E
A
K
N
I
N
K
S
L
S
A
L
G
N
V
Site 22
S260
K
N
I
N
K
S
L
S
A
L
G
N
V
I
S
Site 23
T275
A
L
A
E
G
T
K
T
H
V
P
Y
R
D
S
Site 24
S282
T
H
V
P
Y
R
D
S
K
M
T
R
I
L
Q
Site 25
T285
P
Y
R
D
S
K
M
T
R
I
L
Q
D
S
L
Site 26
S291
M
T
R
I
L
Q
D
S
L
G
G
N
C
R
T
Site 27
S316
F
N
E
A
E
T
K
S
T
L
M
F
G
Q
R
Site 28
T317
N
E
A
E
T
K
S
T
L
M
F
G
Q
R
A
Site 29
T326
M
F
G
Q
R
A
K
T
I
K
N
T
V
S
V
Site 30
T330
R
A
K
T
I
K
N
T
V
S
V
N
L
E
L
Site 31
S332
K
T
I
K
N
T
V
S
V
N
L
E
L
T
A
Site 32
T338
V
S
V
N
L
E
L
T
A
E
E
W
K
K
K
Site 33
Y346
A
E
E
W
K
K
K
Y
E
K
E
K
E
K
N
Site 34
T355
K
E
K
E
K
N
K
T
L
K
N
V
I
Q
H
Site 35
T396
N
L
E
P
C
D
N
T
P
I
I
D
N
I
A
Site 36
Y417
S
T
E
E
K
E
K
Y
D
E
E
I
S
S
L
Site 37
S423
K
Y
D
E
E
I
S
S
L
Y
R
Q
L
D
D
Site 38
S458
D
Q
D
E
L
L
A
S
T
R
R
D
Y
E
K
Site 39
Y463
L
A
S
T
R
R
D
Y
E
K
I
Q
E
E
L
Site 40
S502
A
V
N
Y
D
Q
K
S
Q
E
V
E
D
K
T
Site 41
T509
S
Q
E
V
E
D
K
T
R
A
N
E
Q
L
T
Site 42
T529
K
T
T
T
L
T
T
T
Q
R
E
L
S
Q
L
Site 43
S534
T
T
T
Q
R
E
L
S
Q
L
Q
E
L
S
N
Site 44
S540
L
S
Q
L
Q
E
L
S
N
H
Q
K
K
R
A
Site 45
T548
N
H
Q
K
K
R
A
T
E
I
L
N
L
L
L
Site 46
Y590
E
F
T
M
A
R
L
Y
I
S
K
M
K
S
E
Site 47
S592
T
M
A
R
L
Y
I
S
K
M
K
S
E
V
K
Site 48
S596
L
Y
I
S
K
M
K
S
E
V
K
S
L
V
N
Site 49
S600
K
M
K
S
E
V
K
S
L
V
N
R
S
K
Q
Site 50
S605
V
K
S
L
V
N
R
S
K
Q
L
E
S
A
Q
Site 51
S610
N
R
S
K
Q
L
E
S
A
Q
M
D
S
N
R
Site 52
S615
L
E
S
A
Q
M
D
S
N
R
K
M
N
A
S
Site 53
S622
S
N
R
K
M
N
A
S
E
R
E
L
A
A
C
Site 54
Y646
K
I
K
S
L
T
D
Y
M
Q
N
M
E
Q
K
Site 55
S660
K
R
R
Q
L
E
E
S
Q
D
S
L
S
E
E
Site 56
S663
Q
L
E
E
S
Q
D
S
L
S
E
E
L
A
K
Site 57
S665
E
E
S
Q
D
S
L
S
E
E
L
A
K
L
R
Site 58
S681
Q
E
K
M
H
E
V
S
F
Q
D
K
E
K
E
Site 59
S709
A
L
E
Q
Q
M
E
S
H
R
E
A
H
Q
K
Site 60
S751
L
E
Q
E
K
L
S
S
D
Y
N
K
L
K
I
Site 61
Y753
Q
E
K
L
S
S
D
Y
N
K
L
K
I
E
D
Site 62
T790
D
L
K
G
L
E
E
T
V
S
R
E
L
Q
T
Site 63
S792
K
G
L
E
E
T
V
S
R
E
L
Q
T
L
H
Site 64
T797
T
V
S
R
E
L
Q
T
L
H
N
L
R
K
L
Site 65
T810
K
L
F
V
Q
D
L
T
T
R
V
K
K
S
V
Site 66
S816
L
T
T
R
V
K
K
S
V
E
L
D
N
D
D
Site 67
S835
A
A
Q
K
Q
K
I
S
F
L
E
N
N
L
E
Site 68
T872
L
E
K
R
L
R
A
T
A
E
R
V
K
A
L
Site 69
Y897
A
M
R
D
R
K
R
Y
Q
Q
E
V
D
R
I
Site 70
S919
N
M
A
R
R
A
H
S
A
Q
I
A
K
P
I
Site 71
Y931
K
P
I
R
P
G
H
Y
P
A
S
S
P
T
A
Site 72
S934
R
P
G
H
Y
P
A
S
S
P
T
A
V
H
A
Site 73
S935
P
G
H
Y
P
A
S
S
P
T
A
V
H
A
I
Site 74
T937
H
Y
P
A
S
S
P
T
A
V
H
A
I
R
G
Site 75
S948
A
I
R
G
G
G
G
S
S
S
N
S
T
H
Y
Site 76
S950
R
G
G
G
G
S
S
S
N
S
T
H
Y
Q
K
Site 77
S952
G
G
G
S
S
S
N
S
T
H
Y
Q
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation