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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MED14
Full Name:
Mediator of RNA polymerase II transcription subunit 14
Alias:
Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP150; CRSP2; CSP2; CSRP; CXorf4; DRIP150; EXLM1; Mediator complex subunit 14; RGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Transcriptional coactivator CRSP150; TRAP170; Vitamin D3 receptor-interacting protein complex 150 kDa component
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
160607
Number AA:
1454
UniProt ID:
O60244
International Prot ID:
IPI00297191
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0016455
GO:0030374
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045944
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
P
G
G
G
G
G
G
S
G
G
P
P
S
A
P
Site 2
S26
G
G
S
G
G
P
P
S
A
P
A
P
P
P
P
Site 3
S77
T
D
L
L
P
R
K
S
D
V
E
R
K
I
E
Site 4
S151
L
V
H
A
R
L
P
S
F
A
I
P
Y
A
I
Site 5
T171
G
S
Y
P
R
L
P
T
C
I
R
D
K
I
I
Site 6
T184
I
I
P
P
D
P
I
T
K
I
E
K
Q
A
T
Site 7
T191
T
K
I
E
K
Q
A
T
L
H
Q
L
N
Q
I
Site 8
T205
I
L
R
H
R
L
V
T
T
D
L
P
P
Q
L
Site 9
T216
P
P
Q
L
A
N
L
T
V
A
N
G
R
V
K
Site 10
T233
V
E
G
E
F
E
A
T
L
T
V
M
G
D
D
Site 11
T235
G
E
F
E
A
T
L
T
V
M
G
D
D
P
D
Site 12
T259
I
L
V
E
D
K
E
T
G
D
G
R
A
L
V
Site 13
Y293
E
K
P
L
Q
D
M
Y
N
C
L
H
S
F
C
Site 14
T349
Q
Q
V
L
G
R
K
T
G
T
A
S
V
H
K
Site 15
S353
G
R
K
T
G
T
A
S
V
H
K
V
T
I
K
Site 16
S367
K
I
D
E
N
D
V
S
K
P
L
Q
I
F
H
Site 17
S381
H
D
P
P
L
P
A
S
D
S
K
L
V
E
R
Site 18
S383
P
P
L
P
A
S
D
S
K
L
V
E
R
A
M
Site 19
S404
I
E
K
L
L
I
D
S
V
H
A
R
A
H
Q
Site 20
T474
L
Y
G
L
D
Q
A
T
L
D
D
M
E
K
S
Site 21
S481
T
L
D
D
M
E
K
S
V
N
D
D
M
K
R
Site 22
S508
G
Q
Q
R
C
K
Q
S
I
K
H
L
P
T
I
Site 23
T514
Q
S
I
K
H
L
P
T
I
S
S
E
T
L
Q
Site 24
S517
K
H
L
P
T
I
S
S
E
T
L
Q
L
S
N
Site 25
T519
L
P
T
I
S
S
E
T
L
Q
L
S
N
Y
S
Site 26
S523
S
S
E
T
L
Q
L
S
N
Y
S
T
H
P
I
Site 27
Y525
E
T
L
Q
L
S
N
Y
S
T
H
P
I
G
N
Site 28
T527
L
Q
L
S
N
Y
S
T
H
P
I
G
N
L
S
Site 29
S534
T
H
P
I
G
N
L
S
K
N
K
L
F
I
K
Site 30
T543
N
K
L
F
I
K
L
T
R
L
P
Q
Y
Y
I
Site 31
Y566
N
K
P
T
Q
L
S
Y
K
Y
Y
F
M
S
V
Site 32
Y568
P
T
Q
L
S
Y
K
Y
Y
F
M
S
V
N
A
Site 33
Y569
T
Q
L
S
Y
K
Y
Y
F
M
S
V
N
A
A
Site 34
S581
N
A
A
D
R
E
D
S
P
A
M
A
L
L
L
Site 35
T604
D
L
V
F
R
T
K
T
G
K
Q
T
R
T
N
Site 36
S617
T
N
A
K
R
K
L
S
D
D
P
C
P
V
E
Site 37
T628
C
P
V
E
S
K
K
T
K
R
A
G
E
M
C
Site 38
S662
V
G
L
R
L
E
L
S
N
L
E
I
P
H
Q
Site 39
S679
Q
V
E
G
D
G
F
S
H
A
I
R
L
L
K
Site 40
S704
T
Q
K
A
L
D
R
S
L
L
D
C
T
F
R
Site 41
T709
D
R
S
L
L
D
C
T
F
R
L
Q
G
R
N
Site 42
S735
N
C
P
L
N
G
T
S
T
R
E
Q
G
P
S
Site 43
S742
S
T
R
E
Q
G
P
S
R
H
V
Y
L
T
Y
Site 44
Y746
Q
G
P
S
R
H
V
Y
L
T
Y
E
N
L
L
Site 45
T748
P
S
R
H
V
Y
L
T
Y
E
N
L
L
S
E
Site 46
Y749
S
R
H
V
Y
L
T
Y
E
N
L
L
S
E
P
Site 47
S754
L
T
Y
E
N
L
L
S
E
P
V
G
G
R
K
Site 48
Y805
S
E
V
R
V
Y
N
Y
R
K
L
I
L
C
Y
Site 49
S819
Y
G
T
T
K
G
S
S
I
S
I
Q
W
N
S
Site 50
S821
T
T
K
G
S
S
I
S
I
Q
W
N
S
I
H
Site 51
S834
I
H
Q
K
F
H
I
S
L
G
T
V
G
P
N
Site 52
T837
K
F
H
I
S
L
G
T
V
G
P
N
S
G
C
Site 53
T894
T
V
P
M
L
G
L
T
Q
R
T
N
T
A
Y
Site 54
T899
G
L
T
Q
R
T
N
T
A
Y
Q
C
F
S
I
Site 55
Y901
T
Q
R
T
N
T
A
Y
Q
C
F
S
I
L
P
Site 56
S905
N
T
A
Y
Q
C
F
S
I
L
P
Q
S
S
T
Site 57
T912
S
I
L
P
Q
S
S
T
H
I
R
L
A
F
R
Site 58
Y941
V
A
I
R
D
G
A
Y
S
L
F
D
N
S
K
Site 59
S942
A
I
R
D
G
A
Y
S
L
F
D
N
S
K
L
Site 60
S947
A
Y
S
L
F
D
N
S
K
L
V
E
G
F
Y
Site 61
Y954
S
K
L
V
E
G
F
Y
P
A
P
G
L
K
T
Site 62
S977
N
Q
D
A
R
R
R
S
V
N
E
D
D
N
P
Site 63
S986
N
E
D
D
N
P
P
S
P
I
G
G
D
M
M
Site 64
S998
D
M
M
D
S
L
I
S
Q
L
Q
P
P
P
Q
Site 65
T1015
P
F
P
K
Q
P
G
T
S
G
A
Y
P
L
T
Site 66
Y1019
Q
P
G
T
S
G
A
Y
P
L
T
S
P
P
T
Site 67
T1022
T
S
G
A
Y
P
L
T
S
P
P
T
S
Y
H
Site 68
S1023
S
G
A
Y
P
L
T
S
P
P
T
S
Y
H
S
Site 69
T1026
Y
P
L
T
S
P
P
T
S
Y
H
S
T
V
N
Site 70
S1027
P
L
T
S
P
P
T
S
Y
H
S
T
V
N
Q
Site 71
S1030
S
P
P
T
S
Y
H
S
T
V
N
Q
S
P
S
Site 72
T1031
P
P
T
S
Y
H
S
T
V
N
Q
S
P
S
M
Site 73
S1037
S
T
V
N
Q
S
P
S
M
M
H
T
Q
S
P
Site 74
T1041
Q
S
P
S
M
M
H
T
Q
S
P
G
N
L
H
Site 75
S1043
P
S
M
M
H
T
Q
S
P
G
N
L
H
A
A
Site 76
S1051
P
G
N
L
H
A
A
S
S
P
S
G
A
L
R
Site 77
S1052
G
N
L
H
A
A
S
S
P
S
G
A
L
R
A
Site 78
S1064
L
R
A
P
S
P
A
S
F
V
P
T
P
P
P
Site 79
T1068
S
P
A
S
F
V
P
T
P
P
P
S
S
H
G
Site 80
S1072
F
V
P
T
P
P
P
S
S
H
G
I
S
I
G
Site 81
S1073
V
P
T
P
P
P
S
S
H
G
I
S
I
G
P
Site 82
S1077
P
P
S
S
H
G
I
S
I
G
P
G
A
S
F
Site 83
S1086
G
P
G
A
S
F
A
S
P
H
G
T
L
D
P
Site 84
T1090
S
F
A
S
P
H
G
T
L
D
P
S
S
P
Y
Site 85
S1094
P
H
G
T
L
D
P
S
S
P
Y
T
M
V
S
Site 86
S1095
H
G
T
L
D
P
S
S
P
Y
T
M
V
S
P
Site 87
Y1097
T
L
D
P
S
S
P
Y
T
M
V
S
P
S
G
Site 88
T1098
L
D
P
S
S
P
Y
T
M
V
S
P
S
G
R
Site 89
S1101
S
S
P
Y
T
M
V
S
P
S
G
R
A
G
N
Site 90
S1103
P
Y
T
M
V
S
P
S
G
R
A
G
N
W
P
Site 91
S1112
R
A
G
N
W
P
G
S
P
Q
V
S
G
P
S
Site 92
S1116
W
P
G
S
P
Q
V
S
G
P
S
P
A
A
R
Site 93
S1119
S
P
Q
V
S
G
P
S
P
A
A
R
M
P
G
Site 94
S1128
A
A
R
M
P
G
M
S
P
A
N
P
S
L
H
Site 95
S1133
G
M
S
P
A
N
P
S
L
H
S
P
V
P
D
Site 96
S1136
P
A
N
P
S
L
H
S
P
V
P
D
A
S
H
Site 97
S1142
H
S
P
V
P
D
A
S
H
S
P
R
A
G
T
Site 98
S1144
P
V
P
D
A
S
H
S
P
R
A
G
T
S
S
Site 99
T1149
S
H
S
P
R
A
G
T
S
S
Q
T
M
P
T
Site 100
S1151
S
P
R
A
G
T
S
S
Q
T
M
P
T
N
M
Site 101
T1156
T
S
S
Q
T
M
P
T
N
M
P
P
P
R
K
Site 102
S1168
P
R
K
L
P
Q
R
S
W
A
A
S
I
P
T
Site 103
S1172
P
Q
R
S
W
A
A
S
I
P
T
I
L
T
H
Site 104
S1254
L
K
C
R
V
A
L
S
P
K
T
N
Q
T
L
Site 105
T1266
Q
T
L
Q
L
K
V
T
P
E
N
A
G
Q
W
Site 106
S1374
L
Q
L
T
Q
K
T
S
V
P
P
Q
E
P
V
Site 107
S1393
P
I
I
Y
D
M
A
S
G
T
T
Q
Q
A
D
Site 108
S1408
I
P
R
Q
Q
N
S
S
V
A
A
P
M
M
V
Site 109
T1434
P
P
R
Q
G
E
C
T
I
F
A
A
V
R
D
Site 110
T1447
R
D
L
M
A
N
L
T
L
P
P
G
G
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation