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Updated November 2019
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Protein Info
Short Name:
BAI2
Full Name:
Brain-specific angiogenesis inhibitor 2
Alias:
brain-specific angiogenesis inhibitor 2; brain-specific angiongenesis inhibitor-2
Type:
Receptor, GPCR
Mass (Da):
172656
Number AA:
1585
UniProt ID:
O60241
International Prot ID:
IPI00297188
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0016527
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S78
N
P
D
P
T
K
Y
S
L
Y
L
R
F
N
R
Site 2
Y80
D
P
T
K
Y
S
L
Y
L
R
F
N
R
Q
E
Site 3
S113
N
F
T
C
L
R
P
S
P
E
E
A
V
A
Q
Site 4
S123
E
A
V
A
Q
A
E
S
E
V
G
R
P
E
E
Site 5
T149
C
S
G
S
G
P
F
T
F
L
H
F
D
K
N
Site 6
S163
N
F
V
Q
L
C
L
S
A
E
P
S
E
A
P
Site 7
S224
G
F
A
Q
P
G
C
S
C
P
G
E
A
G
A
Site 8
S233
P
G
E
A
G
A
G
S
T
T
T
T
S
P
G
Site 9
T236
A
G
A
G
S
T
T
T
T
S
P
G
P
P
A
Site 10
T237
G
A
G
S
T
T
T
T
S
P
G
P
P
A
A
Site 11
S238
A
G
S
T
T
T
T
S
P
G
P
P
A
A
H
Site 12
S266
P
A
E
A
D
L
H
S
G
S
S
N
D
L
F
Site 13
S268
E
A
D
L
H
S
G
S
S
N
D
L
F
T
T
Site 14
S269
A
D
L
H
S
G
S
S
N
D
L
F
T
T
E
Site 15
T274
G
S
S
N
D
L
F
T
T
E
M
R
Y
G
E
Site 16
T275
S
S
N
D
L
F
T
T
E
M
R
Y
G
E
E
Site 17
Y279
L
F
T
T
E
M
R
Y
G
E
E
P
E
E
E
Site 18
T291
E
E
E
P
K
V
K
T
Q
W
P
R
S
A
D
Site 19
S296
V
K
T
Q
W
P
R
S
A
D
E
P
G
L
Y
Site 20
Y303
S
A
D
E
P
G
L
Y
M
A
Q
T
G
D
P
Site 21
T307
P
G
L
Y
M
A
Q
T
G
D
P
A
A
E
E
Site 22
S316
D
P
A
A
E
E
W
S
P
W
S
V
C
S
L
Site 23
S335
G
L
Q
V
R
T
R
S
C
V
S
S
P
Y
G
Site 24
S338
V
R
T
R
S
C
V
S
S
P
Y
G
T
L
C
Site 25
S339
R
T
R
S
C
V
S
S
P
Y
G
T
L
C
S
Site 26
Y341
R
S
C
V
S
S
P
Y
G
T
L
C
S
G
P
Site 27
S346
S
P
Y
G
T
L
C
S
G
P
L
R
E
T
R
Site 28
T352
C
S
G
P
L
R
E
T
R
P
C
N
N
S
A
Site 29
S377
W
G
S
W
S
L
C
S
R
S
C
G
R
G
S
Site 30
S379
S
W
S
L
C
S
R
S
C
G
R
G
S
R
S
Site 31
S384
S
R
S
C
G
R
G
S
R
S
R
M
R
T
C
Site 32
S386
S
C
G
R
G
S
R
S
R
M
R
T
C
V
P
Site 33
T390
G
S
R
S
R
M
R
T
C
V
P
P
Q
H
G
Site 34
T439
S
T
S
C
A
N
G
T
Q
Q
R
S
R
K
C
Site 35
S443
A
N
G
T
Q
Q
R
S
R
K
C
S
V
A
G
Site 36
S447
Q
Q
R
S
R
K
C
S
V
A
G
P
A
W
A
Site 37
T461
A
T
C
T
G
A
L
T
D
T
R
E
C
S
N
Site 38
T463
C
T
G
A
L
T
D
T
R
E
C
S
N
L
E
Site 39
S467
L
T
D
T
R
E
C
S
N
L
E
C
P
A
T
Site 40
T474
S
N
L
E
C
P
A
T
D
S
K
W
G
P
W
Site 41
T505
R
F
R
M
C
Q
A
T
G
T
Q
G
Y
P
C
Site 42
Y510
Q
A
T
G
T
Q
G
Y
P
C
E
G
T
G
E
Site 43
S523
G
E
E
V
K
P
C
S
E
K
R
C
P
A
F
Site 44
Y554
A
A
A
G
E
I
I
Y
N
K
C
P
P
N
A
Site 45
S562
N
K
C
P
P
N
A
S
G
S
A
S
R
R
C
Site 46
S564
C
P
P
N
A
S
G
S
A
S
R
R
C
L
L
Site 47
S566
P
N
A
S
G
S
A
S
R
R
C
L
L
S
A
Site 48
Y594
C
I
S
H
E
Y
R
Y
L
Y
L
S
L
R
E
Site 49
Y596
S
H
E
Y
R
Y
L
Y
L
S
L
R
E
H
L
Site 50
S598
E
Y
R
Y
L
Y
L
S
L
R
E
H
L
A
K
Site 51
S621
G
M
S
Q
V
V
R
S
L
Q
E
L
L
A
R
Site 52
T630
Q
E
L
L
A
R
R
T
Y
Y
S
G
D
L
L
Site 53
Y631
E
L
L
A
R
R
T
Y
Y
S
G
D
L
L
F
Site 54
Y632
L
L
A
R
R
T
Y
Y
S
G
D
L
L
F
S
Site 55
T647
V
D
I
L
R
N
V
T
D
T
F
K
R
A
T
Site 56
T649
I
L
R
N
V
T
D
T
F
K
R
A
T
Y
V
Site 57
T654
T
D
T
F
K
R
A
T
Y
V
P
S
A
D
D
Site 58
Y655
D
T
F
K
R
A
T
Y
V
P
S
A
D
D
V
Site 59
S688
W
D
D
A
Q
Q
V
S
P
G
S
V
H
L
L
Site 60
S732
S
I
Q
R
E
P
V
S
A
V
S
S
D
I
T
Site 61
S736
E
P
V
S
A
V
S
S
D
I
T
F
P
M
R
Site 62
T739
S
A
V
S
S
D
I
T
F
P
M
R
G
R
R
Site 63
S755
M
K
D
W
V
R
H
S
E
D
R
L
F
L
P
Site 64
S767
F
L
P
K
E
V
L
S
L
S
S
P
G
K
P
Site 65
S769
P
K
E
V
L
S
L
S
S
P
G
K
P
A
T
Site 66
S770
K
E
V
L
S
L
S
S
P
G
K
P
A
T
S
Site 67
T776
S
S
P
G
K
P
A
T
S
G
A
A
G
S
P
Site 68
S777
S
P
G
K
P
A
T
S
G
A
A
G
S
P
G
Site 69
S782
A
T
S
G
A
A
G
S
P
G
R
G
R
G
P
Site 70
T791
G
R
G
R
G
P
G
T
V
P
P
G
P
G
H
Site 71
S799
V
P
P
G
P
G
H
S
H
Q
R
L
L
P
A
Site 72
T843
A
V
T
S
R
V
M
T
V
T
V
R
P
P
T
Site 73
T845
T
S
R
V
M
T
V
T
V
R
P
P
T
Q
P
Site 74
T850
T
V
T
V
R
P
P
T
Q
P
P
A
E
P
L
Site 75
Y879
P
H
C
A
S
W
D
Y
S
R
A
D
A
S
S
Site 76
S880
H
C
A
S
W
D
Y
S
R
A
D
A
S
S
G
Site 77
S886
Y
S
R
A
D
A
S
S
G
D
W
D
T
E
N
Site 78
T891
A
S
S
G
D
W
D
T
E
N
C
Q
T
L
E
Site 79
T925
A
Q
P
P
K
D
L
T
L
E
L
A
G
S
P
Site 80
T1031
A
V
I
G
R
M
R
T
R
L
V
R
K
R
F
Site 81
Y1062
G
F
T
R
T
K
G
Y
G
T
S
S
Y
C
W
Site 82
S1065
R
T
K
G
Y
G
T
S
S
Y
C
W
L
S
L
Site 83
S1066
T
K
G
Y
G
T
S
S
Y
C
W
L
S
L
E
Site 84
Y1067
K
G
Y
G
T
S
S
Y
C
W
L
S
L
E
G
Site 85
S1109
L
M
A
R
D
G
I
S
D
K
S
K
K
Q
R
Site 86
S1112
R
D
G
I
S
D
K
S
K
K
Q
R
A
G
S
Site 87
S1119
S
K
K
Q
R
A
G
S
E
R
C
P
W
A
S
Site 88
S1146
S
P
L
L
S
S
A
S
A
R
N
A
M
A
S
Site 89
S1225
G
V
C
R
A
D
E
S
E
D
S
P
D
S
C
Site 90
S1228
R
A
D
E
S
E
D
S
P
D
S
C
K
N
G
Site 91
S1231
E
S
E
D
S
P
D
S
C
K
N
G
Q
L
Q
Site 92
S1241
N
G
Q
L
Q
I
L
S
D
F
E
K
D
V
D
Site 93
T1266
V
N
T
C
N
P
S
T
I
T
G
T
L
S
R
Site 94
T1270
N
P
S
T
I
T
G
T
L
S
R
L
S
L
D
Site 95
S1272
S
T
I
T
G
T
L
S
R
L
S
L
D
E
D
Site 96
S1275
T
G
T
L
S
R
L
S
L
D
E
D
E
E
P
Site 97
S1284
D
E
D
E
E
P
K
S
C
L
V
G
P
E
G
Site 98
S1294
V
G
P
E
G
S
L
S
F
S
P
L
P
G
N
Site 99
Y1325
P
Q
E
A
N
P
V
Y
M
C
G
E
G
G
L
Site 100
T1338
G
L
R
Q
L
D
L
T
W
L
R
P
T
E
P
Site 101
T1343
D
L
T
W
L
R
P
T
E
P
G
S
E
G
D
Site 102
S1347
L
R
P
T
E
P
G
S
E
G
D
Y
M
V
L
Site 103
Y1351
E
P
G
S
E
G
D
Y
M
V
L
P
R
R
T
Site 104
T1358
Y
M
V
L
P
R
R
T
L
S
L
Q
P
G
G
Site 105
S1360
V
L
P
R
R
T
L
S
L
Q
P
G
G
G
G
Site 106
T1381
P
R
A
R
P
E
G
T
P
R
R
A
A
K
T
Site 107
T1388
T
P
R
R
A
A
K
T
V
A
H
T
E
G
Y
Site 108
T1392
A
A
K
T
V
A
H
T
E
G
Y
P
S
F
L
Site 109
Y1395
T
V
A
H
T
E
G
Y
P
S
F
L
S
V
D
Site 110
S1397
A
H
T
E
G
Y
P
S
F
L
S
V
D
H
S
Site 111
S1400
E
G
Y
P
S
F
L
S
V
D
H
S
G
L
G
Site 112
Y1412
G
L
G
L
G
P
A
Y
G
S
L
Q
N
P
Y
Site 113
S1414
G
L
G
P
A
Y
G
S
L
Q
N
P
Y
G
M
Site 114
Y1419
Y
G
S
L
Q
N
P
Y
G
M
T
F
Q
P
P
Site 115
T1422
L
Q
N
P
Y
G
M
T
F
Q
P
P
P
P
T
Site 116
T1429
T
F
Q
P
P
P
P
T
P
S
A
R
Q
V
P
Site 117
S1431
Q
P
P
P
P
T
P
S
A
R
Q
V
P
E
P
Site 118
T1444
E
P
G
E
R
S
R
T
M
P
R
T
V
P
G
Site 119
T1448
R
S
R
T
M
P
R
T
V
P
G
S
T
M
K
Site 120
S1452
M
P
R
T
V
P
G
S
T
M
K
M
G
S
L
Site 121
S1458
G
S
T
M
K
M
G
S
L
E
R
K
K
L
R
Site 122
Y1466
L
E
R
K
K
L
R
Y
S
D
L
D
F
E
K
Site 123
S1467
E
R
K
K
L
R
Y
S
D
L
D
F
E
K
V
Site 124
S1482
M
H
T
R
K
R
H
S
E
L
Y
H
E
L
N
Site 125
Y1485
R
K
R
H
S
E
L
Y
H
E
L
N
Q
K
F
Site 126
T1494
E
L
N
Q
K
F
H
T
F
D
R
Y
R
S
Q
Site 127
Y1498
K
F
H
T
F
D
R
Y
R
S
Q
S
T
A
K
Site 128
S1500
H
T
F
D
R
Y
R
S
Q
S
T
A
K
R
E
Site 129
S1502
F
D
R
Y
R
S
Q
S
T
A
K
R
E
K
R
Site 130
S1511
A
K
R
E
K
R
W
S
V
S
S
G
G
A
A
Site 131
S1514
E
K
R
W
S
V
S
S
G
G
A
A
E
R
S
Site 132
S1521
S
G
G
A
A
E
R
S
V
C
T
D
K
P
S
Site 133
T1524
A
A
E
R
S
V
C
T
D
K
P
S
P
G
E
Site 134
S1528
S
V
C
T
D
K
P
S
P
G
E
R
P
S
L
Site 135
S1534
P
S
P
G
E
R
P
S
L
S
Q
H
R
R
H
Site 136
S1536
P
G
E
R
P
S
L
S
Q
H
R
R
H
Q
S
Site 137
S1543
S
Q
H
R
R
H
Q
S
W
S
T
F
K
S
M
Site 138
T1546
R
R
H
Q
S
W
S
T
F
K
S
M
T
L
G
Site 139
S1549
Q
S
W
S
T
F
K
S
M
T
L
G
S
L
P
Site 140
T1551
W
S
T
F
K
S
M
T
L
G
S
L
P
P
K
Site 141
S1554
F
K
S
M
T
L
G
S
L
P
P
K
P
R
E
Site 142
T1564
P
K
P
R
E
R
L
T
L
H
R
A
A
A
W
Site 143
T1574
R
A
A
A
W
E
P
T
E
P
P
D
G
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation