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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX16
Full Name:
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Alias:
DBP2; DEAH-box protein 16; EC=3.6.1.-; KIAA0577
Type:
DNA binding protein, helicase
Mass (Da):
119264
Number AA:
1041
UniProt ID:
O60231
International Prot ID:
IPI00552073
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003724
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
W
V
Q
D
E
L
H
S
V
L
G
L
S
E
R
Site 2
T38
I
G
T
A
Q
R
C
T
S
A
E
E
F
V
Q
Site 3
S39
G
T
A
Q
R
C
T
S
A
E
E
F
V
Q
R
Site 4
T50
F
V
Q
R
L
R
D
T
D
T
L
D
L
S
G
Site 5
T52
Q
R
L
R
D
T
D
T
L
D
L
S
G
P
A
Site 6
S56
D
T
D
T
L
D
L
S
G
P
A
R
D
F
A
Site 7
S96
A
L
L
E
K
N
R
S
Y
R
L
L
E
D
S
Site 8
Y97
L
L
E
K
N
R
S
Y
R
L
L
E
D
S
E
Site 9
S103
S
Y
R
L
L
E
D
S
E
E
S
S
E
E
T
Site 10
S106
L
L
E
D
S
E
E
S
S
E
E
T
V
S
R
Site 11
S107
L
E
D
S
E
E
S
S
E
E
T
V
S
R
A
Site 12
T110
S
E
E
S
S
E
E
T
V
S
R
A
G
S
S
Site 13
S112
E
S
S
E
E
T
V
S
R
A
G
S
S
L
Q
Site 14
S116
E
T
V
S
R
A
G
S
S
L
Q
K
K
R
K
Site 15
S117
T
V
S
R
A
G
S
S
L
Q
K
K
R
K
K
Site 16
S141
E
E
E
E
E
E
A
S
E
K
G
K
K
K
T
Site 17
T155
T
G
G
S
K
Q
Q
T
E
K
P
E
S
E
D
Site 18
S160
Q
Q
T
E
K
P
E
S
E
D
E
W
E
R
T
Site 19
T167
S
E
D
E
W
E
R
T
E
R
E
R
L
Q
D
Site 20
T193
R
Q
R
D
K
D
R
T
R
N
V
L
E
R
S
Site 21
S230
V
P
E
L
R
K
K
S
R
R
E
Y
L
A
K
Site 22
Y234
R
K
K
S
R
R
E
Y
L
A
K
R
E
R
E
Site 23
S263
L
F
G
D
V
E
L
S
R
H
E
R
Q
E
L
Site 24
Y272
H
E
R
Q
E
L
K
Y
K
R
R
V
R
D
L
Site 25
Y283
V
R
D
L
A
R
E
Y
R
A
A
G
E
Q
E
Site 26
Y298
K
L
E
A
T
N
R
Y
H
M
P
K
E
T
R
Site 27
S319
V
D
L
V
E
E
E
S
G
A
P
G
E
E
Q
Site 28
S338
E
A
R
L
G
A
A
S
L
K
F
G
A
R
D
Site 29
S348
F
G
A
R
D
A
A
S
Q
E
P
K
Y
Q
L
Site 30
Y353
A
A
S
Q
E
P
K
Y
Q
L
V
L
E
E
E
Site 31
T369
T
I
E
F
V
R
A
T
Q
L
Q
G
D
E
E
Site 32
S378
L
Q
G
D
E
E
P
S
A
P
P
T
S
T
Q
Site 33
T382
E
E
P
S
A
P
P
T
S
T
Q
A
Q
Q
K
Site 34
S383
E
P
S
A
P
P
T
S
T
Q
A
Q
Q
K
E
Site 35
S398
S
I
Q
A
V
R
R
S
L
P
V
F
P
F
R
Site 36
T430
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
F
Site 37
Y435
K
T
T
Q
I
P
Q
Y
L
F
E
E
G
Y
T
Site 38
Y441
Q
Y
L
F
E
E
G
Y
T
N
K
G
M
K
I
Site 39
T442
Y
L
F
E
E
G
Y
T
N
K
G
M
K
I
A
Site 40
T451
K
G
M
K
I
A
C
T
Q
P
R
R
V
A
A
Site 41
S480
L
G
N
E
V
G
Y
S
I
R
F
E
D
C
T
Site 42
T487
S
I
R
F
E
D
C
T
S
E
R
T
V
L
R
Site 43
S488
I
R
F
E
D
C
T
S
E
R
T
V
L
R
Y
Site 44
Y495
S
E
R
T
V
L
R
Y
M
T
D
G
M
L
L
Site 45
T497
R
T
V
L
R
Y
M
T
D
G
M
L
L
R
E
Site 46
S552
E
L
K
V
L
V
A
S
A
T
M
D
T
A
R
Site 47
T554
K
V
L
V
A
S
A
T
M
D
T
A
R
F
S
Site 48
S561
T
M
D
T
A
R
F
S
T
F
F
D
D
A
P
Site 49
T562
M
D
T
A
R
F
S
T
F
F
D
D
A
P
V
Site 50
Y583
R
F
P
V
D
I
F
Y
T
K
A
P
E
A
D
Site 51
T584
F
P
V
D
I
F
Y
T
K
A
P
E
A
D
Y
Site 52
Y591
T
K
A
P
E
A
D
Y
L
E
A
C
V
V
S
Site 53
S637
D
R
C
R
R
L
G
S
K
I
R
E
L
L
V
Site 54
T663
Q
A
R
I
F
Q
P
T
P
P
G
A
R
K
V
Site 55
Y700
G
F
C
K
Q
K
S
Y
N
P
R
T
G
M
E
Site 56
T704
Q
K
S
Y
N
P
R
T
G
M
E
S
L
T
V
Site 57
S708
N
P
R
T
G
M
E
S
L
T
V
T
P
C
S
Site 58
T710
R
T
G
M
E
S
L
T
V
T
P
C
S
K
A
Site 59
T712
G
M
E
S
L
T
V
T
P
C
S
K
A
S
A
Site 60
S715
S
L
T
V
T
P
C
S
K
A
S
A
N
Q
R
Site 61
T750
Y
Q
H
E
L
E
E
T
T
V
P
E
I
Q
R
Site 62
S811
H
L
G
E
L
T
T
S
G
R
K
M
A
E
L
Site 63
S831
L
S
K
M
I
L
A
S
E
K
Y
S
C
S
E
Site 64
S835
I
L
A
S
E
K
Y
S
C
S
E
E
I
L
T
Site 65
S837
A
S
E
K
Y
S
C
S
E
E
I
L
T
V
A
Site 66
S852
A
M
L
S
V
N
N
S
I
F
Y
R
P
K
D
Site 67
S907
E
N
F
V
Q
F
R
S
M
R
R
A
R
D
V
Site 68
S930
E
R
V
E
V
G
L
S
S
C
Q
G
D
Y
I
Site 69
Y936
L
S
S
C
Q
G
D
Y
I
R
V
R
K
A
I
Site 70
Y947
R
K
A
I
T
A
G
Y
F
Y
H
T
A
R
L
Site 71
T951
T
A
G
Y
F
Y
H
T
A
R
L
T
R
S
G
Site 72
T955
F
Y
H
T
A
R
L
T
R
S
G
Y
R
T
V
Site 73
S957
H
T
A
R
L
T
R
S
G
Y
R
T
V
K
Q
Site 74
Y959
A
R
L
T
R
S
G
Y
R
T
V
K
Q
Q
Q
Site 75
T961
L
T
R
S
G
Y
R
T
V
K
Q
Q
Q
T
V
Site 76
T967
R
T
V
K
Q
Q
Q
T
V
F
I
H
P
N
S
Site 77
S974
T
V
F
I
H
P
N
S
S
L
F
E
Q
Q
P
Site 78
S975
V
F
I
H
P
N
S
S
L
F
E
Q
Q
P
R
Site 79
Y986
Q
Q
P
R
W
L
L
Y
H
E
L
V
L
T
T
Site 80
T992
L
Y
H
E
L
V
L
T
T
K
E
F
M
R
Q
Site 81
Y1015
L
L
E
V
A
P
H
Y
Y
K
A
K
E
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation