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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1B10
Full Name:
Aldo-keto reductase family 1 member B10
Alias:
AK1BA; AKBA; ALD2; Aldose reductase-like; Aldose reductase-related protein; ARP; EC 1.1.1.21; SI reductase
Type:
Enzyme, oxidoreductase
Mass (Da):
36021
Number AA:
316
UniProt ID:
O60218
International Prot ID:
IPI00105407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004033
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006081
GO:0007586
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
V
G
L
G
T
W
K
S
P
L
G
K
V
K
E
Site 2
Y40
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
Site 3
Y47
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
Site 4
Y49
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
Site 5
T96
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Site 6
Y108
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
Site 7
S118
H
W
P
Q
G
F
K
S
G
D
D
L
F
P
K
Site 8
Y178
L
N
K
P
G
L
K
Y
K
P
V
T
N
Q
V
Site 9
T182
G
L
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Site 10
Y190
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Site 11
Y199
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
Site 12
T206
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
Site 13
Y210
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
D
Site 14
S211
G
I
T
V
T
A
Y
S
P
L
G
S
P
D
R
Site 15
S215
T
A
Y
S
P
L
G
S
P
D
R
P
W
A
K
Site 16
S227
W
A
K
P
E
D
P
S
L
L
E
D
P
K
I
Site 17
S282
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
Site 18
T288
L
S
D
E
E
M
A
T
I
L
S
F
N
R
N
Site 19
S291
E
E
M
A
T
I
L
S
F
N
R
N
W
R
A
Site 20
Y310
Q
S
S
H
L
E
D
Y
P
F
D
A
E
Y
_
Site 21
Y316
D
Y
P
F
D
A
E
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation