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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PEX1
Full Name:
Peroxisome biogenesis factor 1
Alias:
Peroxin1; Peroxin-1; Peroxisomal biogenesis factor 1; Peroxisome biogenesis disorder 1; ZWS1; ZWS1 Gene Symbols;Â PEX1
Type:
Hydrolase
Mass (Da):
142867
Number AA:
1283
UniProt ID:
O43933
International Prot ID:
IPI00411291
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005778
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042623
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0060152
GO:0016558
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S59
S
H
Q
P
A
F
L
S
W
V
E
G
R
H
F
Site 2
S67
W
V
E
G
R
H
F
S
D
Q
G
E
N
V
A
Site 3
S102
K
P
C
S
H
V
V
S
C
Q
Q
V
E
V
E
Site 4
S112
Q
V
E
V
E
P
L
S
A
D
D
W
E
I
L
Site 5
T171
A
S
Y
G
R
L
E
T
D
T
K
L
L
I
Q
Site 6
T173
Y
G
R
L
E
T
D
T
K
L
L
I
Q
P
K
Site 7
T181
K
L
L
I
Q
P
K
T
R
R
A
K
E
N
T
Site 8
T188
T
R
R
A
K
E
N
T
F
S
K
A
D
A
E
Site 9
S190
R
A
K
E
N
T
F
S
K
A
D
A
E
Y
K
Site 10
Y196
F
S
K
A
D
A
E
Y
K
K
L
H
S
Y
G
Site 11
S201
A
E
Y
K
K
L
H
S
Y
G
R
D
Q
K
G
Site 12
Y202
E
Y
K
K
L
H
S
Y
G
R
D
Q
K
G
M
Site 13
S228
N
T
V
G
I
T
E
S
N
E
N
E
S
E
I
Site 14
S233
T
E
S
N
E
N
E
S
E
I
P
V
D
S
S
Site 15
S239
E
S
E
I
P
V
D
S
S
S
V
A
S
L
W
Site 16
S240
S
E
I
P
V
D
S
S
S
V
A
S
L
W
T
Site 17
S254
T
M
I
G
S
I
F
S
F
Q
S
E
K
K
Q
Site 18
S264
S
E
K
K
Q
E
T
S
W
G
L
T
E
I
N
Site 19
T268
Q
E
T
S
W
G
L
T
E
I
N
A
F
K
N
Site 20
S278
N
A
F
K
N
M
Q
S
K
V
V
P
L
D
N
Site 21
S296
V
C
K
S
Q
P
P
S
I
Y
N
A
S
A
T
Site 22
Y298
K
S
Q
P
P
S
I
Y
N
A
S
A
T
S
V
Site 23
S301
P
P
S
I
Y
N
A
S
A
T
S
V
F
H
K
Site 24
Y321
V
F
P
W
D
Q
E
Y
F
D
V
E
P
S
F
Site 25
S327
E
Y
F
D
V
E
P
S
F
T
V
T
Y
G
K
Site 26
S340
G
K
L
V
K
L
L
S
P
K
Q
Q
Q
S
K
Site 27
T348
P
K
Q
Q
Q
S
K
T
K
Q
N
V
L
S
P
Site 28
S354
K
T
K
Q
N
V
L
S
P
E
K
E
K
Q
M
Site 29
S362
P
E
K
E
K
Q
M
S
E
P
L
D
Q
K
K
Site 30
T438
R
I
T
P
V
E
V
T
P
K
I
P
R
S
L
Site 31
S444
V
T
P
K
I
P
R
S
L
K
L
Q
P
R
E
Site 32
S458
E
N
L
P
K
D
I
S
E
E
D
I
K
T
V
Site 33
T464
I
S
E
E
D
I
K
T
V
F
Y
S
W
L
Q
Site 34
S500
K
D
G
L
K
E
F
S
L
S
I
V
H
S
W
Site 35
S502
G
L
K
E
F
S
L
S
I
V
H
S
W
E
K
Site 36
S506
F
S
L
S
I
V
H
S
W
E
K
E
K
D
K
Site 37
S519
D
K
N
I
F
L
L
S
P
N
L
L
Q
K
T
Site 38
S566
V
N
S
L
G
V
S
S
L
E
H
I
T
H
S
Site 39
S573
S
L
E
H
I
T
H
S
L
L
G
R
P
L
S
Site 40
T598
R
N
G
A
L
L
L
T
G
G
K
G
S
G
K
Site 41
S606
G
G
K
G
S
G
K
S
T
L
A
K
A
I
C
Site 42
T607
G
K
G
S
G
K
S
T
L
A
K
A
I
C
K
Site 43
S679
A
V
P
E
H
E
H
S
P
D
A
V
Q
S
Q
Site 44
S685
H
S
P
D
A
V
Q
S
Q
R
L
A
H
A
L
Site 45
S714
A
L
I
A
T
S
Q
S
Q
Q
S
L
H
P
L
Site 46
S717
A
T
S
Q
S
Q
Q
S
L
H
P
L
L
V
S
Site 47
S794
L
V
D
R
A
I
H
S
R
L
S
R
Q
S
I
Site 48
S797
R
A
I
H
S
R
L
S
R
Q
S
I
S
T
R
Site 49
S800
H
S
R
L
S
R
Q
S
I
S
T
R
E
K
L
Site 50
S802
R
L
S
R
Q
S
I
S
T
R
E
K
L
V
L
Site 51
T803
L
S
R
Q
S
I
S
T
R
E
K
L
V
L
T
Site 52
T810
T
R
E
K
L
V
L
T
T
L
D
F
Q
K
A
Site 53
T811
R
E
K
L
V
L
T
T
L
D
F
Q
K
A
L
Site 54
T875
N
L
P
I
R
Q
R
T
G
I
L
L
Y
G
P
Site 55
Y880
Q
R
T
G
I
L
L
Y
G
P
P
G
T
G
K
Site 56
T885
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
G
Site 57
S904
E
S
R
M
N
F
I
S
V
K
G
P
E
L
L
Site 58
S912
V
K
G
P
E
L
L
S
K
Y
I
G
A
S
E
Site 59
Y914
G
P
E
L
L
S
K
Y
I
G
A
S
E
Q
A
Site 60
S944
L
F
F
D
E
F
E
S
I
A
P
R
R
G
H
Site 61
T954
P
R
R
G
H
D
N
T
G
V
T
D
R
V
V
Site 62
T957
G
H
D
N
T
G
V
T
D
R
V
V
N
Q
L
Site 63
Y1004
G
R
L
D
K
C
V
Y
C
P
P
P
D
Q
V
Site 64
S1041
H
V
A
S
V
T
D
S
F
T
G
A
D
L
K
Site 65
S1066
L
H
G
M
L
L
S
S
G
L
Q
D
G
S
S
Site 66
S1072
S
S
G
L
Q
D
G
S
S
S
S
D
S
D
L
Site 67
S1073
S
G
L
Q
D
G
S
S
S
S
D
S
D
L
S
Site 68
S1074
G
L
Q
D
G
S
S
S
S
D
S
D
L
S
L
Site 69
S1075
L
Q
D
G
S
S
S
S
D
S
D
L
S
L
S
Site 70
S1077
D
G
S
S
S
S
D
S
D
L
S
L
S
S
M
Site 71
S1082
S
D
S
D
L
S
L
S
S
M
V
F
L
N
H
Site 72
S1083
D
S
D
L
S
L
S
S
M
V
F
L
N
H
S
Site 73
S1090
S
M
V
F
L
N
H
S
S
G
S
D
D
S
A
Site 74
S1091
M
V
F
L
N
H
S
S
G
S
D
D
S
A
G
Site 75
S1096
H
S
S
G
S
D
D
S
A
G
D
G
E
C
G
Site 76
S1107
G
E
C
G
L
D
Q
S
L
V
S
L
E
M
S
Site 77
S1114
S
L
V
S
L
E
M
S
E
I
L
P
D
E
S
Site 78
S1121
S
E
I
L
P
D
E
S
K
F
N
M
Y
R
L
Site 79
Y1126
D
E
S
K
F
N
M
Y
R
L
Y
F
G
S
S
Site 80
Y1129
K
F
N
M
Y
R
L
Y
F
G
S
S
Y
E
S
Site 81
S1132
M
Y
R
L
Y
F
G
S
S
Y
E
S
E
L
G
Site 82
S1133
Y
R
L
Y
F
G
S
S
Y
E
S
E
L
G
N
Site 83
Y1134
R
L
Y
F
G
S
S
Y
E
S
E
L
G
N
G
Site 84
S1136
Y
F
G
S
S
Y
E
S
E
L
G
N
G
T
S
Site 85
T1142
E
S
E
L
G
N
G
T
S
S
D
L
S
S
Q
Site 86
S1143
S
E
L
G
N
G
T
S
S
D
L
S
S
Q
C
Site 87
S1144
E
L
G
N
G
T
S
S
D
L
S
S
Q
C
L
Site 88
S1147
N
G
T
S
S
D
L
S
S
Q
C
L
S
A
P
Site 89
S1148
G
T
S
S
D
L
S
S
Q
C
L
S
A
P
S
Site 90
S1152
D
L
S
S
Q
C
L
S
A
P
S
S
M
T
Q
Site 91
S1156
Q
C
L
S
A
P
S
S
M
T
Q
D
L
P
G
Site 92
S1172
P
G
K
D
Q
L
F
S
Q
P
P
V
L
R
T
Site 93
T1179
S
Q
P
P
V
L
R
T
A
S
Q
E
G
C
Q
Site 94
S1181
P
P
V
L
R
T
A
S
Q
E
G
C
Q
E
L
Site 95
S1201
D
Q
L
R
A
D
I
S
I
I
K
G
R
Y
R
Site 96
Y1207
I
S
I
I
K
G
R
Y
R
S
Q
S
G
E
D
Site 97
S1209
I
I
K
G
R
Y
R
S
Q
S
G
E
D
E
S
Site 98
S1211
K
G
R
Y
R
S
Q
S
G
E
D
E
S
M
N
Site 99
S1216
S
Q
S
G
E
D
E
S
M
N
Q
P
G
P
I
Site 100
T1236
I
S
Q
S
H
L
M
T
A
L
G
H
T
R
P
Site 101
S1244
A
L
G
H
T
R
P
S
I
S
E
D
D
W
K
Site 102
S1246
G
H
T
R
P
S
I
S
E
D
D
W
K
N
F
Site 103
Y1257
W
K
N
F
A
E
L
Y
E
S
F
Q
N
P
K
Site 104
S1259
N
F
A
E
L
Y
E
S
F
Q
N
P
K
R
R
Site 105
S1270
P
K
R
R
K
N
Q
S
G
T
M
F
R
P
G
Site 106
T1272
R
R
K
N
Q
S
G
T
M
F
R
P
G
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation