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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XPNPEP2
Full Name:
Xaa-Pro aminopeptidase 2
Alias:
Aminoacylproline aminopeptidase;Membrane-bound aminopeptidase P;X-Pro aminopeptidase 2
Type:
Mass (Da):
75625
Number AA:
674
UniProt ID:
O43895
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
G
Q
D
V
R
N
C
S
T
N
P
P
Y
L
P
Site 2
Y42
N
C
S
T
N
P
P
Y
L
P
V
T
V
V
N
Site 3
S53
T
V
V
N
T
T
M
S
L
T
A
L
R
Q
Q
Site 4
T63
A
L
R
Q
Q
M
Q
T
Q
N
L
S
A
Y
I
Site 5
Y69
Q
T
Q
N
L
S
A
Y
I
I
P
G
T
D
A
Site 6
T74
S
A
Y
I
I
P
G
T
D
A
H
M
N
E
Y
Site 7
Y81
T
D
A
H
M
N
E
Y
I
G
Q
H
D
E
R
Site 8
T93
D
E
R
R
A
W
I
T
G
F
T
G
S
A
G
Site 9
Y117
A
V
W
T
D
S
R
Y
W
T
Q
A
E
R
Q
Site 10
S162
G
F
D
P
F
L
L
S
I
D
T
W
E
S
Y
Site 11
S168
L
S
I
D
T
W
E
S
Y
D
L
A
L
Q
G
Site 12
Y169
S
I
D
T
W
E
S
Y
D
L
A
L
Q
G
S
Site 13
S176
Y
D
L
A
L
Q
G
S
N
R
Q
L
V
S
I
Site 14
S194
L
V
D
L
V
W
G
S
E
R
P
P
V
P
N
Site 15
Y205
P
V
P
N
Q
P
I
Y
A
L
Q
E
A
F
T
Site 16
S221
S
T
W
Q
E
K
V
S
G
V
R
S
Q
M
Q
Site 17
S225
E
K
V
S
G
V
R
S
Q
M
Q
K
H
Q
K
Site 18
Y258
L
R
A
S
D
I
P
Y
N
P
F
F
Y
S
Y
Site 19
S264
P
Y
N
P
F
F
Y
S
Y
T
L
L
T
D
S
Site 20
S272
Y
T
L
L
T
D
S
S
I
R
L
F
A
N
K
Site 21
S280
I
R
L
F
A
N
K
S
R
F
S
S
E
T
L
Site 22
S283
F
A
N
K
S
R
F
S
S
E
T
L
S
Y
L
Site 23
S284
A
N
K
S
R
F
S
S
E
T
L
S
Y
L
N
Site 24
T286
K
S
R
F
S
S
E
T
L
S
Y
L
N
S
S
Site 25
S288
R
F
S
S
E
T
L
S
Y
L
N
S
S
C
T
Site 26
Y289
F
S
S
E
T
L
S
Y
L
N
S
S
C
T
G
Site 27
S292
E
T
L
S
Y
L
N
S
S
C
T
G
P
M
C
Site 28
Y305
M
C
V
Q
I
E
D
Y
S
Q
V
R
D
S
I
Site 29
S306
C
V
Q
I
E
D
Y
S
Q
V
R
D
S
I
Q
Site 30
S311
D
Y
S
Q
V
R
D
S
I
Q
A
Y
S
L
G
Site 31
Y328
R
I
W
I
G
T
S
Y
T
M
Y
G
I
Y
E
Site 32
Y334
S
Y
T
M
Y
G
I
Y
E
M
I
P
K
E
K
Site 33
T344
I
P
K
E
K
L
V
T
D
T
Y
S
P
V
M
Site 34
T346
K
E
K
L
V
T
D
T
Y
S
P
V
M
M
T
Site 35
Y347
E
K
L
V
T
D
T
Y
S
P
V
M
M
T
K
Site 36
S348
K
L
V
T
D
T
Y
S
P
V
M
M
T
K
A
Site 37
Y379
D
A
V
A
V
I
R
Y
L
V
W
L
E
K
N
Site 38
T391
E
K
N
V
P
K
G
T
V
D
E
F
S
G
A
Site 39
S396
K
G
T
V
D
E
F
S
G
A
E
I
V
D
K
Site 40
S411
F
R
G
E
E
Q
F
S
S
G
P
S
F
E
T
Site 41
S412
R
G
E
E
Q
F
S
S
G
P
S
F
E
T
I
Site 42
S415
E
Q
F
S
S
G
P
S
F
E
T
I
S
A
S
Site 43
T418
S
S
G
P
S
F
E
T
I
S
A
S
G
L
N
Site 44
S422
S
F
E
T
I
S
A
S
G
L
N
A
A
L
A
Site 45
S432
N
A
A
L
A
H
Y
S
P
T
K
E
L
N
R
Site 46
S442
K
E
L
N
R
K
L
S
S
D
E
M
Y
L
L
Site 47
S443
E
L
N
R
K
L
S
S
D
E
M
Y
L
L
D
Site 48
Y447
K
L
S
S
D
E
M
Y
L
L
D
S
G
G
Q
Site 49
Y455
L
L
D
S
G
G
Q
Y
W
D
G
T
T
D
I
Site 50
T465
G
T
T
D
I
T
R
T
V
H
W
G
T
P
S
Site 51
T470
T
R
T
V
H
W
G
T
P
S
A
F
Q
K
E
Site 52
Y479
S
A
F
Q
K
E
A
Y
T
R
V
L
I
G
N
Site 53
Y518
L
W
D
A
G
L
N
Y
G
H
G
T
G
H
G
Site 54
Y558
F
T
S
I
E
P
G
Y
Y
K
D
G
E
F
G
Site 55
Y559
T
S
I
E
P
G
Y
Y
K
D
G
E
F
G
I
Site 56
Y581
V
V
E
A
K
T
K
Y
P
G
S
Y
L
T
F
Site 57
S584
A
K
T
K
Y
P
G
S
Y
L
T
F
E
V
V
Site 58
S592
Y
L
T
F
E
V
V
S
F
V
P
Y
D
R
N
Site 59
S604
D
R
N
L
I
D
V
S
L
L
S
P
E
H
L
Site 60
Y613
L
S
P
E
H
L
Q
Y
L
N
R
Y
Y
Q
T
Site 61
Y617
H
L
Q
Y
L
N
R
Y
Y
Q
T
I
R
E
K
Site 62
Y618
L
Q
Y
L
N
R
Y
Y
Q
T
I
R
E
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation