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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AHCYL1
Full Name:
Putative adenosylhomocysteinase 2
Alias:
Adenosylhomocysteinase-like 1; AdoHcyase; DCAL; DC-expressed AHCY-like molecule; Inositol 1,4,5-trisphosphate receptor-binding protein; IRBIT; RP11-180N18.1-001; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein; S-adenosylhomocysteine hydrolase-like protein 1; S-adenosyl-L-homocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase 2; SAHH2; XPVKONA
Type:
Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid; Hydrolase
Mass (Da):
58951
Number AA:
530
UniProt ID:
O43865
International Prot ID:
IPI00182938
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0004013
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
M
P
D
A
M
P
L
Site 2
Y28
E
I
E
D
A
E
K
Y
S
F
M
A
T
V
T
Site 3
S29
I
E
D
A
E
K
Y
S
F
M
A
T
V
T
K
Site 4
T33
E
K
Y
S
F
M
A
T
V
T
K
A
P
K
K
Site 5
T35
Y
S
F
M
A
T
V
T
K
A
P
K
K
Q
I
Site 6
T58
F
T
K
F
P
T
K
T
G
R
R
S
L
S
R
Site 7
S62
P
T
K
T
G
R
R
S
L
S
R
S
I
S
Q
Site 8
S64
K
T
G
R
R
S
L
S
R
S
I
S
Q
S
S
Site 9
S66
G
R
R
S
L
S
R
S
I
S
Q
S
S
T
D
Site 10
S68
R
S
L
S
R
S
I
S
Q
S
S
T
D
S
Y
Site 11
S70
L
S
R
S
I
S
Q
S
S
T
D
S
Y
S
S
Site 12
S71
S
R
S
I
S
Q
S
S
T
D
S
Y
S
S
A
Site 13
T72
R
S
I
S
Q
S
S
T
D
S
Y
S
S
A
A
Site 14
S74
I
S
Q
S
S
T
D
S
Y
S
S
A
A
S
Y
Site 15
Y75
S
Q
S
S
T
D
S
Y
S
S
A
A
S
Y
T
Site 16
S76
Q
S
S
T
D
S
Y
S
S
A
A
S
Y
T
D
Site 17
S77
S
S
T
D
S
Y
S
S
A
A
S
Y
T
D
S
Site 18
S80
D
S
Y
S
S
A
A
S
Y
T
D
S
S
D
D
Site 19
Y81
S
Y
S
S
A
A
S
Y
T
D
S
S
D
D
E
Site 20
T82
Y
S
S
A
A
S
Y
T
D
S
S
D
D
E
V
Site 21
S84
S
A
A
S
Y
T
D
S
S
D
D
E
V
S
P
Site 22
S85
A
A
S
Y
T
D
S
S
D
D
E
V
S
P
R
Site 23
S90
D
S
S
D
D
E
V
S
P
R
E
K
Q
Q
T
Site 24
T97
S
P
R
E
K
Q
Q
T
N
S
K
G
S
S
N
Site 25
S99
R
E
K
Q
Q
T
N
S
K
G
S
S
N
F
C
Site 26
S103
Q
T
N
S
K
G
S
S
N
F
C
V
K
N
I
Site 27
S128
E
I
A
E
Q
D
M
S
A
L
I
S
L
R
K
Site 28
S132
Q
D
M
S
A
L
I
S
L
R
K
R
A
Q
G
Site 29
T234
L
D
D
G
G
D
L
T
H
W
V
Y
K
K
Y
Site 30
Y238
G
D
L
T
H
W
V
Y
K
K
Y
P
N
V
F
Site 31
Y241
T
H
W
V
Y
K
K
Y
P
N
V
F
K
K
I
Site 32
T257
G
I
V
E
E
S
V
T
G
V
H
R
L
Y
Q
Site 33
Y263
V
T
G
V
H
R
L
Y
Q
L
S
K
A
G
K
Site 34
S281
P
A
M
N
V
N
D
S
V
T
K
Q
K
F
D
Site 35
Y291
K
Q
K
F
D
N
L
Y
C
C
R
E
S
I
L
Site 36
S296
N
L
Y
C
C
R
E
S
I
L
D
G
L
K
R
Site 37
T305
L
D
G
L
K
R
T
T
D
V
M
F
G
G
K
Site 38
S391
H
L
D
R
M
K
N
S
C
I
V
C
N
M
G
Site 39
S400
I
V
C
N
M
G
H
S
N
T
E
I
D
V
T
Site 40
T402
C
N
M
G
H
S
N
T
E
I
D
V
T
S
L
Site 41
T407
S
N
T
E
I
D
V
T
S
L
R
T
P
E
L
Site 42
S408
N
T
E
I
D
V
T
S
L
R
T
P
E
L
T
Site 43
T411
I
D
V
T
S
L
R
T
P
E
L
T
W
E
R
Site 44
T415
S
L
R
T
P
E
L
T
W
E
R
V
R
S
Q
Site 45
Y482
G
R
Y
K
Q
D
V
Y
L
L
P
K
K
M
D
Site 46
Y491
L
P
K
K
M
D
E
Y
V
A
S
L
H
L
P
Site 47
S494
K
M
D
E
Y
V
A
S
L
H
L
P
S
F
D
Site 48
Y514
L
T
D
D
Q
A
K
Y
L
G
L
N
K
N
G
Site 49
Y527
N
G
P
F
K
P
N
Y
Y
R
Y
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation