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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NRD1
Full Name:
Nardilysin
Alias:
EC 3.4.24.61; HNRD1; Nardilysin; N-arginine dibasic convertase; NRD convertase; NRDC; NRD-C
Type:
EC 3.4.24.61; Protease
Mass (Da):
131572
Number AA:
1150
UniProt ID:
O43847
International Prot ID:
IPI00478723
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0048408
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016477
GO:0008283
GO:0007528
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
T
R
G
R
C
E
D
S
A
A
A
R
P
F
P
Site 2
S58
P
G
R
N
K
A
K
S
T
C
S
C
P
D
L
Site 3
T59
G
R
N
K
A
K
S
T
C
S
C
P
D
L
Q
Site 4
S61
N
K
A
K
S
T
C
S
C
P
D
L
Q
P
N
Site 5
S86
A
R
L
G
A
D
E
S
E
E
E
G
R
R
G
Site 6
S94
E
E
E
G
R
R
G
S
L
S
N
A
G
D
P
Site 7
S96
E
G
R
R
G
S
L
S
N
A
G
D
P
E
I
Site 8
S106
G
D
P
E
I
V
K
S
P
S
D
P
K
Q
Y
Site 9
S108
P
E
I
V
K
S
P
S
D
P
K
Q
Y
R
Y
Site 10
Y115
S
D
P
K
Q
Y
R
Y
I
K
L
Q
N
G
L
Site 11
S131
A
L
L
I
S
D
L
S
N
M
E
G
K
T
G
Site 12
S159
E
E
D
D
D
E
D
S
G
A
E
I
E
D
D
Site 13
T187
E
H
D
D
D
L
D
T
E
D
N
E
L
E
E
Site 14
T205
R
A
E
A
R
K
K
T
T
E
K
Q
S
A
A
Site 15
Y245
V
F
M
G
S
L
K
Y
P
D
E
N
G
F
D
Site 16
S265
H
G
G
S
D
N
A
S
T
D
C
E
R
T
V
Site 17
T266
G
G
S
D
N
A
S
T
D
C
E
R
T
V
F
Site 18
T271
A
S
T
D
C
E
R
T
V
F
Q
F
D
V
Q
Site 19
Y281
Q
F
D
V
Q
R
K
Y
F
K
E
A
L
D
R
Site 20
S312
R
E
V
E
A
V
D
S
E
Y
Q
L
A
R
P
Site 21
Y314
V
E
A
V
D
S
E
Y
Q
L
A
R
P
S
D
Site 22
S320
E
Y
Q
L
A
R
P
S
D
A
N
R
K
E
M
Site 23
S331
R
K
E
M
L
F
G
S
L
A
R
P
G
H
P
Site 24
T361
P
R
K
N
N
I
D
T
H
A
R
L
R
E
F
Site 25
T379
Y
Y
S
S
H
Y
M
T
L
V
V
Q
S
K
E
Site 26
T390
Q
S
K
E
T
L
D
T
L
E
K
W
V
T
E
Site 27
T396
D
T
L
E
K
W
V
T
E
I
F
S
Q
I
P
Site 28
T416
R
P
N
F
G
H
L
T
D
P
F
D
T
P
A
Site 29
T421
H
L
T
D
P
F
D
T
P
A
F
N
K
L
Y
Site 30
Y428
T
P
A
F
N
K
L
Y
R
V
V
P
I
R
K
Site 31
Y452
L
P
P
Q
Q
Q
H
Y
R
V
K
P
L
H
Y
Site 32
Y459
Y
R
V
K
P
L
H
Y
I
S
W
L
V
G
H
Site 33
S471
V
G
H
E
G
K
G
S
I
L
S
F
L
R
K
Site 34
S474
E
G
K
G
S
I
L
S
F
L
R
K
K
C
W
Site 35
S498
E
T
G
F
E
Q
N
S
T
Y
S
V
F
S
I
Site 36
T499
T
G
F
E
Q
N
S
T
Y
S
V
F
S
I
S
Site 37
Y500
G
F
E
Q
N
S
T
Y
S
V
F
S
I
S
I
Site 38
S501
F
E
Q
N
S
T
Y
S
V
F
S
I
S
I
T
Site 39
T510
F
S
I
S
I
T
L
T
D
E
G
Y
E
H
F
Site 40
Y514
I
T
L
T
D
E
G
Y
E
H
F
Y
E
V
A
Site 41
Y518
D
E
G
Y
E
H
F
Y
E
V
A
Y
T
V
F
Site 42
Y522
E
H
F
Y
E
V
A
Y
T
V
F
Q
Y
L
K
Site 43
Y554
I
E
D
N
E
F
H
Y
Q
E
Q
T
D
P
V
Site 44
Y563
E
Q
T
D
P
V
E
Y
V
E
N
M
C
E
N
Site 45
S638
S
I
E
D
I
E
N
S
W
A
E
L
W
N
S
Site 46
T676
K
A
F
D
C
P
E
T
E
Y
P
V
K
I
V
Site 47
Y678
F
D
C
P
E
T
E
Y
P
V
K
I
V
N
T
Site 48
Y740
H
N
L
A
E
P
A
Y
E
A
D
V
A
Q
L
Site 49
T800
I
T
E
Q
L
K
K
T
Y
F
N
I
L
I
K
Site 50
Y801
T
E
Q
L
K
K
T
Y
F
N
I
L
I
K
P
Site 51
Y831
R
W
S
M
I
D
K
Y
Q
A
L
M
D
G
L
Site 52
Y875
E
S
M
D
F
L
K
Y
V
V
D
K
L
N
F
Site 53
S917
L
N
K
G
D
A
N
S
E
V
T
V
Y
Y
Q
Site 54
T920
G
D
A
N
S
E
V
T
V
Y
Y
Q
S
G
T
Site 55
Y922
A
N
S
E
V
T
V
Y
Y
Q
S
G
T
R
S
Site 56
Y923
N
S
E
V
T
V
Y
Y
Q
S
G
T
R
S
L
Site 57
S925
E
V
T
V
Y
Y
Q
S
G
T
R
S
L
R
E
Site 58
T927
T
V
Y
Y
Q
S
G
T
R
S
L
R
E
Y
T
Site 59
S929
Y
Y
Q
S
G
T
R
S
L
R
E
Y
T
L
M
Site 60
T956
D
F
L
R
T
K
Q
T
L
G
Y
H
V
Y
P
Site 61
Y959
R
T
K
Q
T
L
G
Y
H
V
Y
P
T
C
R
Site 62
Y962
Q
T
L
G
Y
H
V
Y
P
T
C
R
N
T
S
Site 63
Y985
V
G
T
Q
A
T
K
Y
N
S
E
V
V
D
K
Site 64
S999
K
K
I
E
E
F
L
S
S
F
E
E
K
I
E
Site 65
S1000
K
I
E
E
F
L
S
S
F
E
E
K
I
E
N
Site 66
T1029
K
L
K
E
C
E
D
T
H
L
G
E
E
V
D
Site 67
Y1047
N
E
V
V
T
Q
Q
Y
L
F
D
R
L
A
H
Site 68
S1061
H
E
I
E
A
L
K
S
F
S
K
S
D
L
V
Site 69
S1063
I
E
A
L
K
S
F
S
K
S
D
L
V
N
W
Site 70
S1065
A
L
K
S
F
S
K
S
D
L
V
N
W
F
K
Site 71
S1079
K
A
H
R
G
P
G
S
K
M
L
S
V
H
V
Site 72
Y1092
H
V
V
G
Y
G
K
Y
E
L
E
E
D
G
T
Site 73
T1099
Y
E
L
E
E
D
G
T
P
S
S
E
D
S
N
Site 74
S1101
L
E
E
D
G
T
P
S
S
E
D
S
N
S
S
Site 75
S1102
E
E
D
G
T
P
S
S
E
D
S
N
S
S
C
Site 76
S1105
G
T
P
S
S
E
D
S
N
S
S
C
E
V
M
Site 77
S1107
P
S
S
E
D
S
N
S
S
C
E
V
M
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation