KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT86
Full Name:
Keratin, type II cuticular Hb6
Alias:
K2.11; Keratin-86; Type II hair keratin Hb6
Type:
Cytoskeletal protein
Mass (Da):
53501
Number AA:
486
UniProt ID:
O43790
International Prot ID:
IPI00182655
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005882
GO:0044422
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0005198
GO:0005198
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006996
GO:0007010
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Y
C
G
G
R
A
F
S
C
I
S
A
C
G
P
Site 2
S16
G
R
A
F
S
C
I
S
A
C
G
P
R
P
G
Site 3
T28
R
P
G
R
C
C
I
T
A
A
P
Y
R
G
I
Site 4
S36
A
A
P
Y
R
G
I
S
C
Y
R
G
L
T
G
Site 5
Y38
P
Y
R
G
I
S
C
Y
R
G
L
T
G
G
F
Site 6
T42
I
S
C
Y
R
G
L
T
G
G
F
G
S
H
S
Site 7
S49
T
G
G
F
G
S
H
S
V
C
G
G
F
R
A
Site 8
S58
C
G
G
F
R
A
G
S
C
G
R
S
F
G
Y
Site 9
S62
R
A
G
S
C
G
R
S
F
G
Y
R
S
G
G
Site 10
Y65
S
C
G
R
S
F
G
Y
R
S
G
G
V
C
G
Site 11
S67
G
R
S
F
G
Y
R
S
G
G
V
C
G
P
S
Site 12
S112
E
E
K
E
Q
I
K
S
L
N
S
R
F
A
A
Site 13
Y141
L
E
T
K
L
Q
F
Y
Q
N
R
E
C
C
Q
Site 14
S149
Q
N
R
E
C
C
Q
S
N
L
E
P
L
F
E
Site 15
T161
L
F
E
G
Y
I
E
T
L
R
R
E
A
E
C
Site 16
S173
A
E
C
V
E
A
D
S
G
R
L
A
S
E
L
Site 17
S178
A
D
S
G
R
L
A
S
E
L
N
H
V
Q
E
Site 18
Y194
L
E
G
Y
K
K
K
Y
E
E
E
V
S
L
R
Site 19
S199
K
K
Y
E
E
E
V
S
L
R
A
T
A
E
N
Site 20
T203
E
E
V
S
L
R
A
T
A
E
N
E
F
V
A
Site 21
Y219
K
K
D
V
D
C
A
Y
L
R
K
S
D
L
E
Site 22
S223
D
C
A
Y
L
R
K
S
D
L
E
A
N
V
E
Site 23
Y243
I
D
F
L
R
R
L
Y
E
E
E
I
R
V
L
Site 24
S252
E
E
I
R
V
L
Q
S
H
I
S
D
T
S
V
Site 25
S258
Q
S
H
I
S
D
T
S
V
V
V
K
L
D
N
Site 26
Y282
I
A
E
I
K
A
Q
Y
D
D
I
V
T
R
S
Site 27
S289
Y
D
D
I
V
T
R
S
R
A
E
A
E
S
W
Site 28
S295
R
S
R
A
E
A
E
S
W
Y
R
S
K
C
E
Site 29
Y297
R
A
E
A
E
S
W
Y
R
S
K
C
E
E
M
Site 30
S299
E
A
E
S
W
Y
R
S
K
C
E
E
M
K
A
Site 31
T307
K
C
E
E
M
K
A
T
V
I
R
H
G
E
T
Site 32
T314
T
V
I
R
H
G
E
T
L
R
R
T
K
E
E
Site 33
T318
H
G
E
T
L
R
R
T
K
E
E
I
N
E
L
Site 34
T333
N
R
M
I
Q
R
L
T
A
E
V
E
N
A
K
Site 35
S362
Q
Q
G
E
A
A
L
S
D
A
R
C
K
L
A
Site 36
Y389
M
A
C
L
I
R
E
Y
Q
E
V
M
N
S
K
Site 37
T405
G
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
Site 38
Y406
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
E
Site 39
S454
P
V
V
S
T
R
V
S
S
V
P
S
N
S
N
Site 40
S455
V
V
S
T
R
V
S
S
V
P
S
N
S
N
V
Site 41
S458
T
R
V
S
S
V
P
S
N
S
N
V
V
V
G
Site 42
S460
V
S
S
V
P
S
N
S
N
V
V
V
G
T
T
Site 43
T466
N
S
N
V
V
V
G
T
T
N
A
C
A
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation