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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAF3IP2
Full Name:
Adapter protein CIKS
Alias:
Connection to IKK and SAPK/JNK;Nuclear factor NF-kappa-B activator 1;TRAF3-interacting protein 2
Type:
Mass (Da):
64657
Number AA:
574
UniProt ID:
O43734
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
I
P
V
E
V
D
E
S
E
P
Y
P
S
Q
L
Site 2
Y24
E
V
D
E
S
E
P
Y
P
S
Q
L
L
K
P
Site 3
S26
D
E
S
E
P
Y
P
S
Q
L
L
K
P
I
P
Site 4
Y35
L
L
K
P
I
P
E
Y
S
P
E
E
E
S
E
Site 5
S36
L
K
P
I
P
E
Y
S
P
E
E
E
S
E
P
Site 6
S41
E
Y
S
P
E
E
E
S
E
P
P
A
P
N
I
Site 7
S57
N
M
A
P
N
S
L
S
A
P
T
M
L
H
N
Site 8
S65
A
P
T
M
L
H
N
S
S
G
D
F
S
Q
A
Site 9
S66
P
T
M
L
H
N
S
S
G
D
F
S
Q
A
H
Site 10
S70
H
N
S
S
G
D
F
S
Q
A
H
S
T
L
K
Site 11
S74
G
D
F
S
Q
A
H
S
T
L
K
L
A
N
H
Site 12
S86
A
N
H
Q
R
P
V
S
R
Q
V
T
C
L
R
Site 13
T90
R
P
V
S
R
Q
V
T
C
L
R
T
Q
V
L
Site 14
S100
R
T
Q
V
L
E
D
S
E
D
S
F
C
R
R
Site 15
S103
V
L
E
D
S
E
D
S
F
C
R
R
H
P
G
Site 16
S120
K
A
F
P
S
G
C
S
A
V
S
E
P
A
S
Site 17
S123
P
S
G
C
S
A
V
S
E
P
A
S
E
S
V
Site 18
S141
L
P
A
E
H
Q
F
S
F
M
E
K
R
N
Q
Site 19
S152
K
R
N
Q
W
L
V
S
Q
L
S
A
A
S
P
Site 20
S155
Q
W
L
V
S
Q
L
S
A
A
S
P
D
T
G
Site 21
S158
V
S
Q
L
S
A
A
S
P
D
T
G
H
D
S
Site 22
T161
L
S
A
A
S
P
D
T
G
H
D
S
D
K
S
Site 23
S165
S
P
D
T
G
H
D
S
D
K
S
D
Q
S
L
Site 24
S168
T
G
H
D
S
D
K
S
D
Q
S
L
P
N
A
Site 25
S171
D
S
D
K
S
D
Q
S
L
P
N
A
S
A
D
Site 26
S176
D
Q
S
L
P
N
A
S
A
D
S
L
G
G
S
Site 27
S179
L
P
N
A
S
A
D
S
L
G
G
S
Q
E
M
Site 28
S183
S
A
D
S
L
G
G
S
Q
E
M
V
Q
R
P
Site 29
T203
R
A
G
L
D
L
P
T
I
D
T
G
Y
D
S
Site 30
T206
L
D
L
P
T
I
D
T
G
Y
D
S
Q
P
Q
Site 31
Y208
L
P
T
I
D
T
G
Y
D
S
Q
P
Q
D
V
Site 32
S210
T
I
D
T
G
Y
D
S
Q
P
Q
D
V
L
G
Site 33
T228
L
E
R
P
L
P
L
T
S
V
C
Y
P
Q
D
Site 34
S229
E
R
P
L
P
L
T
S
V
C
Y
P
Q
D
L
Site 35
Y232
L
P
L
T
S
V
C
Y
P
Q
D
L
P
R
P
Site 36
Y253
P
Q
F
E
P
Q
R
Y
P
A
C
A
Q
M
L
Site 37
S265
Q
M
L
P
P
N
L
S
P
H
A
P
W
N
Y
Site 38
Y286
S
P
D
H
Q
V
P
Y
G
H
D
Y
P
R
A
Site 39
Y290
Q
V
P
Y
G
H
D
Y
P
R
A
A
Y
Q
Q
Site 40
Y295
H
D
Y
P
R
A
A
Y
Q
Q
V
I
Q
P
A
Site 41
S312
G
Q
P
L
P
G
A
S
V
R
G
L
H
P
V
Site 42
Y326
V
Q
K
V
I
L
N
Y
P
S
P
W
D
Q
E
Site 43
S328
K
V
I
L
N
Y
P
S
P
W
D
Q
E
E
R
Site 44
S342
R
P
A
Q
R
D
C
S
F
P
G
L
P
R
H
Site 45
S367
R
A
G
A
P
G
E
S
L
E
C
P
A
E
L
Site 46
S383
P
Q
V
P
Q
P
P
S
P
A
A
V
P
R
P
Site 47
S392
A
A
V
P
R
P
P
S
N
P
P
A
R
G
T
Site 48
T399
S
N
P
P
A
R
G
T
L
K
T
S
N
L
P
Site 49
T402
P
A
R
G
T
L
K
T
S
N
L
P
E
E
L
Site 50
S403
A
R
G
T
L
K
T
S
N
L
P
E
E
L
R
Site 51
Y459
I
I
K
W
M
E
R
Y
L
R
D
K
T
V
M
Site 52
Y475
I
V
A
I
S
P
K
Y
K
Q
D
V
E
G
A
Site 53
S484
Q
D
V
E
G
A
E
S
Q
L
D
E
D
E
H
Site 54
T531
A
K
K
E
H
V
P
T
W
L
Q
N
T
H
V
Site 55
Y539
W
L
Q
N
T
H
V
Y
S
W
P
K
N
K
K
Site 56
Y558
R
L
L
R
E
E
E
Y
V
A
P
P
R
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation