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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HTATSF1
Full Name:
HIV Tat-specific factor 1
Alias:
HIV TAT specific factor 1; HIV-1 Tat specific factor 1; HTSF1; Tat-SF1
Type:
Transcription, coactivator/corepressor
Mass (Da):
85853
Number AA:
755
UniProt ID:
O43719
International Prot ID:
IPI00013788
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0003702
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0006357
GO:0006350
GO:0019079
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
T
N
L
D
G
N
Site 2
T4
_
_
_
_
M
S
G
T
N
L
D
G
N
D
E
Site 3
Y22
Q
L
R
M
Q
E
L
Y
G
D
G
K
D
G
D
Site 4
T30
G
D
G
K
D
G
D
T
Q
T
D
A
G
G
E
Site 5
T32
G
K
D
G
D
T
Q
T
D
A
G
G
E
P
D
Site 6
S40
D
A
G
G
E
P
D
S
L
G
Q
Q
P
T
D
Site 7
T46
D
S
L
G
Q
Q
P
T
D
T
P
Y
E
W
D
Site 8
T48
L
G
Q
Q
P
T
D
T
P
Y
E
W
D
L
D
Site 9
Y50
Q
Q
P
T
D
T
P
Y
E
W
D
L
D
K
K
Site 10
Y71
T
E
D
F
I
A
T
Y
Q
A
N
Y
G
F
S
Site 11
Y75
I
A
T
Y
Q
A
N
Y
G
F
S
N
D
G
A
Site 12
S78
Y
Q
A
N
Y
G
F
S
N
D
G
A
S
S
S
Site 13
S83
G
F
S
N
D
G
A
S
S
S
T
A
N
V
E
Site 14
S85
S
N
D
G
A
S
S
S
T
A
N
V
E
D
V
Site 15
T133
H
V
E
E
D
R
N
T
N
V
Y
V
S
G
L
Site 16
Y136
E
D
R
N
T
N
V
Y
V
S
G
L
P
P
D
Site 17
T165
I
I
M
R
D
P
Q
T
E
E
F
K
V
K
L
Site 18
Y173
E
E
F
K
V
K
L
Y
K
D
N
Q
G
N
L
Site 19
Y188
K
G
D
G
L
C
C
Y
L
K
R
E
S
V
E
Site 20
Y209
D
E
D
E
I
R
G
Y
K
L
H
V
E
V
A
Site 21
Y224
K
F
Q
L
K
G
E
Y
D
A
S
K
K
K
K
Site 22
S227
L
K
G
E
Y
D
A
S
K
K
K
K
K
C
K
Site 23
Y236
K
K
K
K
C
K
D
Y
K
K
K
L
S
M
Q
Site 24
S241
K
D
Y
K
K
K
L
S
M
Q
Q
K
Q
L
D
Site 25
S258
P
E
R
R
A
G
P
S
R
M
R
H
E
R
V
Site 26
S296
E
D
L
R
V
E
C
S
K
F
G
Q
I
R
K
Site 27
S316
R
H
P
D
G
V
A
S
V
S
F
R
D
P
E
Site 28
S318
P
D
G
V
A
S
V
S
F
R
D
P
E
E
A
Site 29
Y327
R
D
P
E
E
A
D
Y
C
I
Q
T
L
D
G
Site 30
Y353
A
W
D
G
T
T
D
Y
Q
V
E
E
T
S
R
Site 31
S385
A
N
R
G
L
R
R
S
D
S
V
S
A
S
E
Site 32
S387
R
G
L
R
R
S
D
S
V
S
A
S
E
R
A
Site 33
S389
L
R
R
S
D
S
V
S
A
S
E
R
A
G
P
Site 34
S391
R
S
D
S
V
S
A
S
E
R
A
G
P
S
R
Site 35
S397
A
S
E
R
A
G
P
S
R
A
R
H
F
S
E
Site 36
S403
P
S
R
A
R
H
F
S
E
H
P
S
T
S
K
Site 37
S407
R
H
F
S
E
H
P
S
T
S
K
M
N
A
Q
Site 38
T408
H
F
S
E
H
P
S
T
S
K
M
N
A
Q
E
Site 39
S409
F
S
E
H
P
S
T
S
K
M
N
A
Q
E
T
Site 40
S445
G
E
F
E
E
G
A
S
E
N
N
A
K
E
S
Site 41
S452
S
E
N
N
A
K
E
S
S
P
E
K
E
A
E
Site 42
S453
E
N
N
A
K
E
S
S
P
E
K
E
A
E
E
Site 43
S467
E
G
C
P
E
K
E
S
E
E
G
C
P
K
R
Site 44
S479
P
K
R
G
F
E
G
S
C
S
Q
K
E
S
E
Site 45
S481
R
G
F
E
G
S
C
S
Q
K
E
S
E
E
G
Site 46
S485
G
S
C
S
Q
K
E
S
E
E
G
N
P
V
R
Site 47
S494
E
G
N
P
V
R
G
S
E
E
D
S
P
K
K
Site 48
S498
V
R
G
S
E
E
D
S
P
K
K
E
S
K
K
Site 49
T507
K
K
E
S
K
K
K
T
L
K
N
D
C
E
E
Site 50
S521
E
N
G
L
A
K
E
S
E
D
D
L
N
K
E
Site 51
S529
E
D
D
L
N
K
E
S
E
E
E
V
G
P
T
Site 52
T536
S
E
E
E
V
G
P
T
K
E
S
E
E
D
D
Site 53
S539
E
V
G
P
T
K
E
S
E
E
D
D
S
E
K
Site 54
S544
K
E
S
E
E
D
D
S
E
K
E
S
D
E
D
Site 55
S548
E
D
D
S
E
K
E
S
D
E
D
C
S
E
K
Site 56
S553
K
E
S
D
E
D
C
S
E
K
Q
S
E
D
G
Site 57
S557
E
D
C
S
E
K
Q
S
E
D
G
S
E
R
E
Site 58
S561
E
K
Q
S
E
D
G
S
E
R
E
F
E
E
N
Site 59
S579
K
D
L
D
E
E
G
S
E
K
E
L
H
E
N
Site 60
S597
K
E
L
E
E
N
D
S
E
N
S
E
F
E
D
Site 61
S600
E
E
N
D
S
E
N
S
E
F
E
D
D
G
S
Site 62
S607
S
E
F
E
D
D
G
S
E
K
V
L
D
E
E
Site 63
S616
K
V
L
D
E
E
G
S
E
R
E
F
D
E
D
Site 64
S624
E
R
E
F
D
E
D
S
D
E
K
E
E
E
E
Site 65
T633
E
K
E
E
E
E
D
T
Y
E
K
V
F
D
D
Site 66
Y634
K
E
E
E
E
D
T
Y
E
K
V
F
D
D
E
Site 67
S642
E
K
V
F
D
D
E
S
D
E
K
E
D
E
E
Site 68
Y650
D
E
K
E
D
E
E
Y
A
D
E
K
G
L
E
Site 69
S676
D
E
K
L
F
E
E
S
D
D
K
E
D
E
D
Site 70
S702
K
L
F
E
D
D
D
S
N
E
K
L
F
D
E
Site 71
S713
L
F
D
E
E
E
D
S
S
E
K
L
F
D
D
Site 72
S714
F
D
E
E
E
D
S
S
E
K
L
F
D
D
S
Site 73
S721
S
E
K
L
F
D
D
S
D
E
R
G
T
L
G
Site 74
T726
D
D
S
D
E
R
G
T
L
G
G
F
G
S
V
Site 75
S732
G
T
L
G
G
F
G
S
V
E
E
G
P
L
S
Site 76
S742
E
G
P
L
S
T
G
S
S
F
I
L
S
S
D
Site 77
S743
G
P
L
S
T
G
S
S
F
I
L
S
S
D
D
Site 78
S747
T
G
S
S
F
I
L
S
S
D
D
D
D
D
D
Site 79
S748
G
S
S
F
I
L
S
S
D
D
D
D
D
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation