KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPAP2C
Full Name:
Lipid phosphate phosphohydrolase 2
Alias:
LPP2; PAP2c; PAP-2c; PAP2-G; PAP2-gamma; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase type 2C
Type:
Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phosphatase, lipid; EC 3.1.3.4
Mass (Da):
32574
Number AA:
288
UniProt ID:
O43688
International Prot ID:
IPI00216620
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008195
GO:0004721
GO:0042392
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
A
P
Y
K
R
G
F
Y
C
G
D
D
S
I
R
Site 2
Y45
C
G
D
D
S
I
R
Y
P
Y
R
P
D
T
I
Site 3
Y47
D
D
S
I
R
Y
P
Y
R
P
D
T
I
T
H
Site 4
T51
R
Y
P
Y
R
P
D
T
I
T
H
G
L
M
A
Site 5
T53
P
Y
R
P
D
T
I
T
H
G
L
M
A
G
V
Site 6
Y78
A
G
E
A
Y
L
V
Y
T
D
R
L
Y
S
R
Site 7
T79
G
E
A
Y
L
V
Y
T
D
R
L
Y
S
R
S
Site 8
Y83
L
V
Y
T
D
R
L
Y
S
R
S
D
F
N
N
Site 9
S84
V
Y
T
D
R
L
Y
S
R
S
D
F
N
N
Y
Site 10
S86
T
D
R
L
Y
S
R
S
D
F
N
N
Y
V
A
Site 11
Y91
S
R
S
D
F
N
N
Y
V
A
A
V
Y
K
V
Site 12
Y118
S
L
T
D
L
A
K
Y
M
I
G
R
L
R
P
Site 13
T158
R
G
N
P
A
D
V
T
E
A
R
L
S
F
Y
Site 14
S163
D
V
T
E
A
R
L
S
F
Y
S
G
H
S
S
Site 15
Y165
T
E
A
R
L
S
F
Y
S
G
H
S
S
F
G
Site 16
S166
E
A
R
L
S
F
Y
S
G
H
S
S
F
G
M
Site 17
Y182
C
M
V
F
L
A
L
Y
V
Q
A
R
L
C
W
Site 18
Y212
A
F
A
L
Y
V
G
Y
T
R
V
S
D
Y
K
Site 19
Y218
G
Y
T
R
V
S
D
Y
K
H
H
W
S
D
V
Site 20
S266
E
E
L
E
R
K
P
S
L
S
L
T
L
T
L
Site 21
S268
L
E
R
K
P
S
L
S
L
T
L
T
L
G
E
Site 22
T270
R
K
P
S
L
S
L
T
L
T
L
G
E
A
D
Site 23
T272
P
S
L
S
L
T
L
T
L
G
E
A
D
H
N
Site 24
Y281
G
E
A
D
H
N
H
Y
G
Y
P
H
S
S
S
Site 25
Y283
A
D
H
N
H
Y
G
Y
P
H
S
S
S
_
_
Site 26
S286
N
H
Y
G
Y
P
H
S
S
S
_
_
_
_
_
Site 27
S288
Y
G
Y
P
H
S
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation