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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HR
Full Name:
Protein hairless
Alias:
ALUNC; AU; HAIR; hairless
Type:
Nuclear receptor co-regulator
Mass (Da):
127495
Number AA:
1189
UniProt ID:
O43593
International Prot ID:
IPI00292057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
S
T
P
S
F
L
K
G
T
P
T
Site 2
T11
T
P
S
F
L
K
G
T
P
T
W
E
K
T
A
Site 3
T13
S
F
L
K
G
T
P
T
W
E
K
T
A
P
E
Site 4
T17
G
T
P
T
W
E
K
T
A
P
E
N
G
I
V
Site 5
S30
I
V
R
Q
E
P
G
S
P
P
R
D
G
L
H
Site 6
S55
P
F
W
R
G
V
L
S
T
P
D
S
W
L
P
Site 7
T56
F
W
R
G
V
L
S
T
P
D
S
W
L
P
P
Site 8
S59
G
V
L
S
T
P
D
S
W
L
P
P
G
F
P
Site 9
S93
R
K
V
N
W
L
G
S
K
E
G
L
R
W
K
Site 10
T105
R
W
K
E
A
M
L
T
H
P
L
A
F
C
G
Site 11
S127
G
P
L
M
P
E
H
S
G
G
H
L
K
S
D
Site 12
S133
H
S
G
G
H
L
K
S
D
P
V
A
F
R
P
Site 13
S169
C
L
P
P
Y
L
V
S
G
L
P
P
E
H
P
Site 14
Y188
L
T
P
H
P
W
V
Y
S
G
G
Q
P
K
V
Site 15
S197
G
G
Q
P
K
V
P
S
A
F
S
L
G
S
K
Site 16
S200
P
K
V
P
S
A
F
S
L
G
S
K
G
F
Y
Site 17
Y207
S
L
G
S
K
G
F
Y
Y
K
D
P
S
I
P
Site 18
Y208
L
G
S
K
G
F
Y
Y
K
D
P
S
I
P
R
Site 19
S212
G
F
Y
Y
K
D
P
S
I
P
R
L
A
K
E
Site 20
S233
P
G
L
F
G
L
N
S
G
G
H
L
Q
R
A
Site 21
S247
A
G
E
A
E
R
P
S
L
H
Q
R
D
G
E
Site 22
T273
L
F
L
G
Q
P
D
T
V
P
W
T
S
W
P
Site 23
Y304
P
G
D
G
N
L
G
Y
Q
L
G
P
P
A
T
Site 24
T311
Y
Q
L
G
P
P
A
T
P
R
C
P
S
P
E
Site 25
S316
P
A
T
P
R
C
P
S
P
E
P
P
V
T
Q
Site 26
T322
P
S
P
E
P
P
V
T
Q
R
G
C
C
S
S
Site 27
S329
T
Q
R
G
C
C
S
S
Y
P
P
T
K
G
G
Site 28
Y330
Q
R
G
C
C
S
S
Y
P
P
T
K
G
G
G
Site 29
T333
C
C
S
S
Y
P
P
T
K
G
G
G
L
G
P
Site 30
S353
E
G
L
E
G
G
A
S
G
A
S
E
P
S
E
Site 31
S374
G
P
R
A
C
P
P
S
H
H
T
K
L
K
K
Site 32
S416
R
A
L
K
R
A
G
S
P
E
V
Q
G
A
M
Site 33
S425
E
V
Q
G
A
M
G
S
P
A
P
K
R
P
P
Site 34
T438
P
P
D
P
F
P
G
T
A
E
Q
G
A
G
G
Site 35
T452
G
W
Q
E
V
R
D
T
S
I
G
N
K
D
V
Site 36
S453
W
Q
E
V
R
D
T
S
I
G
N
K
D
V
D
Site 37
S461
I
G
N
K
D
V
D
S
G
Q
H
D
E
Q
K
Site 38
S476
G
P
Q
D
G
Q
A
S
L
Q
D
P
G
L
Q
Site 39
S514
G
G
G
H
A
C
H
S
Q
Q
V
R
R
S
P
Site 40
S520
H
S
Q
Q
V
R
R
S
P
L
G
G
E
L
Q
Site 41
T532
E
L
Q
Q
E
E
D
T
A
T
N
S
S
S
E
Site 42
T534
Q
Q
E
E
D
T
A
T
N
S
S
S
E
E
G
Site 43
S536
E
E
D
T
A
T
N
S
S
S
E
E
G
P
G
Site 44
S537
E
D
T
A
T
N
S
S
S
E
E
G
P
G
S
Site 45
S538
D
T
A
T
N
S
S
S
E
E
G
P
G
S
G
Site 46
S544
S
S
E
E
G
P
G
S
G
P
D
S
R
L
S
Site 47
S548
G
P
G
S
G
P
D
S
R
L
S
T
G
L
A
Site 48
S551
S
G
P
D
S
R
L
S
T
G
L
A
K
H
L
Site 49
T552
G
P
D
S
R
L
S
T
G
L
A
K
H
L
L
Site 50
T590
E
G
Q
G
P
A
V
T
E
D
S
P
G
I
P
Site 51
S593
G
P
A
V
T
E
D
S
P
G
I
P
R
C
C
Site 52
T631
A
C
G
R
V
A
G
T
G
R
A
R
E
K
A
Site 53
S644
K
A
G
F
Q
E
Q
S
A
E
E
C
T
Q
E
Site 54
S710
D
A
G
Q
Q
K
E
S
T
Q
K
T
P
P
T
Site 55
T714
Q
K
E
S
T
Q
K
T
P
P
T
P
Q
P
S
Site 56
T717
S
T
Q
K
T
P
P
T
P
Q
P
S
C
N
G
Site 57
S721
T
P
P
T
P
Q
P
S
C
N
G
D
T
H
R
Site 58
T726
Q
P
S
C
N
G
D
T
H
R
T
K
S
I
K
Site 59
S731
G
D
T
H
R
T
K
S
I
K
E
E
T
P
D
Site 60
T736
T
K
S
I
K
E
E
T
P
D
S
A
E
T
P
Site 61
S739
I
K
E
E
T
P
D
S
A
E
T
P
A
E
D
Site 62
T742
E
T
P
D
S
A
E
T
P
A
E
D
R
A
G
Site 63
S789
P
V
T
P
A
L
P
S
D
D
R
I
T
N
I
Site 64
S833
K
G
L
G
L
P
L
S
P
V
R
P
R
L
P
Site 65
S902
G
G
Q
V
Q
A
L
S
P
L
G
P
P
Q
P
Site 66
S910
P
L
G
P
P
Q
P
S
S
L
G
S
T
T
F
Site 67
S911
L
G
P
P
Q
P
S
S
L
G
S
T
T
F
W
Site 68
S914
P
Q
P
S
S
L
G
S
T
T
F
W
E
G
F
Site 69
T915
Q
P
S
S
L
G
S
T
T
F
W
E
G
F
S
Site 70
T916
P
S
S
L
G
S
T
T
F
W
E
G
F
S
W
Site 71
S930
W
P
E
L
R
P
K
S
D
E
G
S
V
L
L
Site 72
S934
R
P
K
S
D
E
G
S
V
L
L
L
H
R
A
Site 73
T947
R
A
L
G
D
E
D
T
S
R
V
E
N
L
A
Site 74
S995
L
W
A
A
Y
G
V
S
P
H
R
G
H
L
G
Site 75
T1003
P
H
R
G
H
L
G
T
K
N
L
C
V
E
V
Site 76
T1022
S
I
L
V
H
A
D
T
P
L
P
A
W
H
R
Site 77
S1036
R
A
Q
K
D
F
L
S
G
L
D
G
E
G
L
Site 78
S1045
L
D
G
E
G
L
W
S
P
G
S
Q
V
S
T
Site 79
S1048
E
G
L
W
S
P
G
S
Q
V
S
T
V
W
H
Site 80
T1052
S
P
G
S
Q
V
S
T
V
W
H
V
F
R
A
Site 81
Y1089
P
G
A
P
G
S
C
Y
L
D
A
G
L
R
R
Site 82
S1142
S
V
T
Q
H
F
L
S
P
E
T
S
A
L
S
Site 83
S1149
S
P
E
T
S
A
L
S
A
Q
L
C
H
Q
G
Site 84
S1158
Q
L
C
H
Q
G
P
S
L
P
P
D
C
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation