KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RGS14
Full Name:
Regulator of G-protein signaling 14
Alias:
RGSE
Type:
GTPase activating protein, RGS
Mass (Da):
61447
Number AA:
566
UniProt ID:
O43566
International Prot ID:
IPI00012893
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005057
PhosphoSite+
KinaseNET
Biological Process:
GO:0009968
GO:0008277
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
G
R
M
V
L
A
V
S
D
G
E
L
S
S
T
Site 2
S25
A
V
S
D
G
E
L
S
S
T
T
G
P
Q
G
Site 3
S26
V
S
D
G
E
L
S
S
T
T
G
P
Q
G
Q
Site 4
T27
S
D
G
E
L
S
S
T
T
G
P
Q
G
Q
G
Site 5
S39
G
Q
G
E
G
R
G
S
S
L
S
I
H
S
L
Site 6
S40
Q
G
E
G
R
G
S
S
L
S
I
H
S
L
P
Site 7
S42
E
G
R
G
S
S
L
S
I
H
S
L
P
S
G
Site 8
S45
G
S
S
L
S
I
H
S
L
P
S
G
P
S
S
Site 9
S48
L
S
I
H
S
L
P
S
G
P
S
S
P
F
P
Site 10
S52
S
L
P
S
G
P
S
S
P
F
P
T
E
E
Q
Site 11
T56
G
P
S
S
P
F
P
T
E
E
Q
P
V
A
S
Site 12
S67
P
V
A
S
W
A
L
S
F
E
R
L
L
Q
D
Site 13
Y80
Q
D
P
L
G
L
A
Y
F
T
E
F
L
K
K
Site 14
S90
E
F
L
K
K
E
F
S
A
E
N
V
T
F
W
Site 15
S109
R
F
Q
Q
I
P
A
S
D
T
Q
Q
L
A
Q
Site 16
Y122
A
Q
E
A
R
N
I
Y
Q
E
F
L
S
S
Q
Site 17
S127
N
I
Y
Q
E
F
L
S
S
Q
A
L
S
P
V
Site 18
S128
I
Y
Q
E
F
L
S
S
Q
A
L
S
P
V
N
Site 19
S132
F
L
S
S
Q
A
L
S
P
V
N
I
D
R
Q
Site 20
S170
F
N
L
M
K
F
D
S
Y
A
R
F
V
K
S
Site 21
Y171
N
L
M
K
F
D
S
Y
A
R
F
V
K
S
P
Site 22
S177
S
Y
A
R
F
V
K
S
P
L
Y
R
E
C
L
Site 23
Y180
R
F
V
K
S
P
L
Y
R
E
C
L
L
A
E
Site 24
S198
R
P
L
R
E
P
G
S
S
R
L
G
S
P
D
Site 25
S199
P
L
R
E
P
G
S
S
R
L
G
S
P
D
A
Site 26
S203
P
G
S
S
R
L
G
S
P
D
A
T
R
K
K
Site 27
T207
R
L
G
S
P
D
A
T
R
K
K
P
K
L
K
Site 28
S218
P
K
L
K
P
G
K
S
L
P
L
G
V
E
E
Site 29
S243
G
G
R
P
L
R
K
S
F
R
R
E
L
G
G
Site 30
T251
F
R
R
E
L
G
G
T
A
N
A
A
L
R
R
Site 31
S260
N
A
A
L
R
R
E
S
Q
G
S
L
N
S
S
Site 32
S263
L
R
R
E
S
Q
G
S
L
N
S
S
A
S
L
Site 33
S267
S
Q
G
S
L
N
S
S
A
S
L
D
L
G
F
Site 34
S279
L
G
F
L
A
F
V
S
S
K
S
E
S
H
R
Site 35
S280
G
F
L
A
F
V
S
S
K
S
E
S
H
R
K
Site 36
S282
L
A
F
V
S
S
K
S
E
S
H
R
K
S
L
Site 37
S284
F
V
S
S
K
S
E
S
H
R
K
S
L
G
S
Site 38
S288
K
S
E
S
H
R
K
S
L
G
S
T
E
G
E
Site 39
S291
S
H
R
K
S
L
G
S
T
E
G
E
S
E
S
Site 40
T292
H
R
K
S
L
G
S
T
E
G
E
S
E
S
R
Site 41
S296
L
G
S
T
E
G
E
S
E
S
R
P
G
K
Y
Site 42
S298
S
T
E
G
E
S
E
S
R
P
G
K
Y
C
C
Site 43
Y303
S
E
S
R
P
G
K
Y
C
C
V
Y
L
P
D
Site 44
Y307
P
G
K
Y
C
C
V
Y
L
P
D
G
T
A
S
Site 45
S338
I
C
E
K
R
G
L
S
L
P
D
I
K
V
Y
Site 46
Y345
S
L
P
D
I
K
V
Y
L
V
G
N
E
Q
A
Site 47
T374
V
R
L
E
N
R
I
T
F
E
L
E
L
T
A
Site 48
S389
L
E
R
V
V
R
I
S
A
K
P
T
K
R
L
Site 49
T393
V
R
I
S
A
K
P
T
K
R
L
Q
E
A
L
Site 50
S450
T
L
P
G
V
K
I
S
K
A
R
D
K
S
P
Site 51
S456
I
S
K
A
R
D
K
S
P
C
R
S
Q
G
C
Site 52
S460
R
D
K
S
P
C
R
S
Q
G
C
P
P
R
T
Site 53
T467
S
Q
G
C
P
P
R
T
Q
D
K
A
T
H
P
Site 54
T472
P
R
T
Q
D
K
A
T
H
P
P
P
A
S
P
Site 55
S478
A
T
H
P
P
P
A
S
P
S
S
L
V
K
V
Site 56
S480
H
P
P
P
A
S
P
S
S
L
V
K
V
P
S
Site 57
S481
P
P
P
A
S
P
S
S
L
V
K
V
P
S
S
Site 58
S487
S
S
L
V
K
V
P
S
S
A
T
G
K
R
Q
Site 59
S488
S
L
V
K
V
P
S
S
A
T
G
K
R
Q
T
Site 60
T490
V
K
V
P
S
S
A
T
G
K
R
Q
T
C
D
Site 61
T495
S
A
T
G
K
R
Q
T
C
D
I
E
G
L
V
Site 62
S510
E
L
L
N
R
V
Q
S
S
G
A
H
D
Q
R
Site 63
S539
Q
L
P
A
Q
G
P
S
S
E
E
T
P
P
Q
Site 64
S540
L
P
A
Q
G
P
S
S
E
E
T
P
P
Q
T
Site 65
T543
Q
G
P
S
S
E
E
T
P
P
Q
T
K
S
A
Site 66
S549
E
T
P
P
Q
T
K
S
A
A
Q
P
I
G
G
Site 67
S557
A
A
Q
P
I
G
G
S
L
N
S
T
T
D
S
Site 68
S560
P
I
G
G
S
L
N
S
T
T
D
S
A
L
_
Site 69
T561
I
G
G
S
L
N
S
T
T
D
S
A
L
_
_
Site 70
T562
G
G
S
L
N
S
T
T
D
S
A
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation