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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv7.2
Full Name:
Potassium voltage-gated channel subfamily KQT member 2
Alias:
BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT-like 2; Neuroblastoma-specific potassium channel alpha subunit KvLQT2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Potassium voltage-gated channel, KQT-like subfamily, member 2; Voltage-gated potassium channel subunit Kv7.2
Type:
Channel protein, potassium
Mass (Da):
95848
Number AA:
872
UniProt ID:
O43526
International Prot ID:
IPI00012858
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0006813
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Potassium voltage-gated channel subfamily KQT member 2 pan-specific antibody AB-NN275-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN275-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
K
S
R
N
G
G
V
Y
P
G
P
S
G
E
K
Site 2
S15
G
G
V
Y
P
G
P
S
G
E
K
K
L
K
V
Site 3
S34
L
D
P
G
A
P
D
S
T
R
D
G
A
L
L
Site 4
S45
G
A
L
L
I
A
G
S
E
A
P
K
R
G
S
Site 5
S52
S
E
A
P
K
R
G
S
I
L
S
K
P
R
A
Site 6
S55
P
K
R
G
S
I
L
S
K
P
R
A
G
G
A
Site 7
Y74
P
P
K
R
N
A
F
Y
R
K
L
Q
N
F
L
Site 8
Y82
R
K
L
Q
N
F
L
Y
N
V
L
E
R
P
R
Site 9
Y118
V
F
S
T
I
K
E
Y
E
K
S
S
E
G
A
Site 10
S121
T
I
K
E
Y
E
K
S
S
E
G
A
L
Y
I
Site 11
T217
R
M
D
R
R
G
G
T
W
K
L
L
G
S
V
Site 12
S223
G
T
W
K
L
L
G
S
V
V
Y
A
H
S
K
Site 13
S229
G
S
V
V
Y
A
H
S
K
E
L
V
T
A
W
Site 14
Y237
K
E
L
V
T
A
W
Y
I
G
F
L
C
L
I
Site 15
Y284
T
I
G
Y
G
D
K
Y
P
Q
T
W
N
G
R
Site 16
T287
Y
G
D
K
Y
P
Q
T
W
N
G
R
L
L
A
Site 17
Y347
I
Q
S
A
W
R
F
Y
A
T
N
L
S
R
T
Site 18
S352
R
F
Y
A
T
N
L
S
R
T
D
L
H
S
T
Site 19
T354
Y
A
T
N
L
S
R
T
D
L
H
S
T
W
Q
Site 20
S358
L
S
R
T
D
L
H
S
T
W
Q
Y
Y
E
R
Site 21
Y362
D
L
H
S
T
W
Q
Y
Y
E
R
T
V
T
V
Site 22
Y363
L
H
S
T
W
Q
Y
Y
E
R
T
V
T
V
P
Site 23
T368
Q
Y
Y
E
R
T
V
T
V
P
M
Y
S
S
Q
Site 24
Y372
R
T
V
T
V
P
M
Y
S
S
Q
T
Q
T
Y
Site 25
S374
V
T
V
P
M
Y
S
S
Q
T
Q
T
Y
G
A
Site 26
T378
M
Y
S
S
Q
T
Q
T
Y
G
A
S
R
L
I
Site 27
Y379
Y
S
S
Q
T
Q
T
Y
G
A
S
R
L
I
P
Site 28
S399
E
L
L
R
N
L
K
S
K
S
G
L
A
F
R
Site 29
S401
L
R
N
L
K
S
K
S
G
L
A
F
R
K
D
Site 30
S414
K
D
P
P
P
E
P
S
P
S
K
G
S
P
C
Site 31
S416
P
P
P
E
P
S
P
S
K
G
S
P
C
R
G
Site 32
S419
E
P
S
P
S
K
G
S
P
C
R
G
P
L
C
Site 33
S433
C
G
C
C
P
G
R
S
S
Q
K
V
S
L
K
Site 34
S434
G
C
C
P
G
R
S
S
Q
K
V
S
L
K
D
Site 35
S438
G
R
S
S
Q
K
V
S
L
K
D
R
V
F
S
Site 36
S445
S
L
K
D
R
V
F
S
S
P
R
G
V
A
A
Site 37
S446
L
K
D
R
V
F
S
S
P
R
G
V
A
A
K
Site 38
S457
V
A
A
K
G
K
G
S
P
Q
A
Q
T
V
R
Site 39
T462
K
G
S
P
Q
A
Q
T
V
R
R
S
P
S
A
Site 40
S466
Q
A
Q
T
V
R
R
S
P
S
A
D
Q
S
L
Site 41
S468
Q
T
V
R
R
S
P
S
A
D
Q
S
L
E
D
Site 42
S472
R
S
P
S
A
D
Q
S
L
E
D
S
P
S
K
Site 43
S476
A
D
Q
S
L
E
D
S
P
S
K
V
P
K
S
Site 44
S478
Q
S
L
E
D
S
P
S
K
V
P
K
S
W
S
Site 45
S483
S
P
S
K
V
P
K
S
W
S
F
G
D
R
S
Site 46
S485
S
K
V
P
K
S
W
S
F
G
D
R
S
R
A
Site 47
S490
S
W
S
F
G
D
R
S
R
A
R
Q
A
F
R
Site 48
S507
G
A
A
S
R
Q
N
S
E
E
A
S
L
P
G
Site 49
S511
R
Q
N
S
E
E
A
S
L
P
G
E
D
I
V
Site 50
S551
C
V
M
R
F
L
V
S
K
R
K
F
K
E
S
Site 51
S558
S
K
R
K
F
K
E
S
L
R
P
Y
D
V
M
Site 52
Y562
F
K
E
S
L
R
P
Y
D
V
M
D
V
I
E
Site 53
Y571
V
M
D
V
I
E
Q
Y
S
A
G
H
L
D
M
Site 54
S580
A
G
H
L
D
M
L
S
R
I
K
S
L
Q
S
Site 55
S584
D
M
L
S
R
I
K
S
L
Q
S
R
V
D
Q
Site 56
T600
V
G
R
G
P
A
I
T
D
K
D
R
T
K
G
Site 57
T605
A
I
T
D
K
D
R
T
K
G
P
A
E
A
E
Site 58
S618
A
E
L
P
E
D
P
S
M
M
G
R
L
G
K
Site 59
S632
K
V
E
K
Q
V
L
S
M
E
K
K
L
D
F
Site 60
Y644
L
D
F
L
V
N
I
Y
M
Q
R
M
G
I
P
Site 61
T655
M
G
I
P
P
T
E
T
E
A
Y
F
G
A
K
Site 62
Y658
P
P
T
E
T
E
A
Y
F
G
A
K
E
P
E
Site 63
Y670
E
P
E
P
A
P
P
Y
H
S
P
E
D
S
R
Site 64
S672
E
P
A
P
P
Y
H
S
P
E
D
S
R
E
H
Site 65
S676
P
Y
H
S
P
E
D
S
R
E
H
V
D
R
H
Site 66
S692
C
I
V
K
I
V
R
S
S
S
S
T
G
Q
K
Site 67
S693
I
V
K
I
V
R
S
S
S
S
T
G
Q
K
N
Site 68
S694
V
K
I
V
R
S
S
S
S
T
G
Q
K
N
F
Site 69
S695
K
I
V
R
S
S
S
S
T
G
Q
K
N
F
S
Site 70
T696
I
V
R
S
S
S
S
T
G
Q
K
N
F
S
A
Site 71
S702
S
T
G
Q
K
N
F
S
A
P
P
A
A
P
P
Site 72
S715
P
P
V
Q
C
P
P
S
T
S
W
Q
P
Q
S
Site 73
T716
P
V
Q
C
P
P
S
T
S
W
Q
P
Q
S
H
Site 74
S717
V
Q
C
P
P
S
T
S
W
Q
P
Q
S
H
P
Site 75
S722
S
T
S
W
Q
P
Q
S
H
P
R
Q
G
H
G
Site 76
T730
H
P
R
Q
G
H
G
T
S
P
V
G
D
H
G
Site 77
S731
P
R
Q
G
H
G
T
S
P
V
G
D
H
G
S
Site 78
S738
S
P
V
G
D
H
G
S
L
V
R
I
P
P
P
Site 79
S751
P
P
P
A
H
E
R
S
L
S
A
Y
G
G
G
Site 80
S753
P
A
H
E
R
S
L
S
A
Y
G
G
G
N
R
Site 81
Y755
H
E
R
S
L
S
A
Y
G
G
G
N
R
A
S
Site 82
S762
Y
G
G
G
N
R
A
S
M
E
F
L
R
Q
E
Site 83
T771
E
F
L
R
Q
E
D
T
P
G
C
R
P
P
E
Site 84
S784
P
E
G
N
L
R
D
S
D
T
S
I
S
I
P
Site 85
T786
G
N
L
R
D
S
D
T
S
I
S
I
P
S
V
Site 86
S787
N
L
R
D
S
D
T
S
I
S
I
P
S
V
D
Site 87
S789
R
D
S
D
T
S
I
S
I
P
S
V
D
H
E
Site 88
S792
D
T
S
I
S
I
P
S
V
D
H
E
E
L
E
Site 89
S801
D
H
E
E
L
E
R
S
F
S
G
F
S
I
S
Site 90
S803
E
E
L
E
R
S
F
S
G
F
S
I
S
Q
S
Site 91
S806
E
R
S
F
S
G
F
S
I
S
Q
S
K
E
N
Site 92
S808
S
F
S
G
F
S
I
S
Q
S
K
E
N
L
D
Site 93
S810
S
G
F
S
I
S
Q
S
K
E
N
L
D
A
L
Site 94
Y833
P
C
A
K
V
R
P
Y
I
A
E
G
E
S
D
Site 95
S839
P
Y
I
A
E
G
E
S
D
T
D
S
D
L
C
Site 96
T841
I
A
E
G
E
S
D
T
D
S
D
L
C
T
P
Site 97
S843
E
G
E
S
D
T
D
S
D
L
C
T
P
C
G
Site 98
T847
D
T
D
S
D
L
C
T
P
C
G
P
P
P
R
Site 99
S855
P
C
G
P
P
P
R
S
A
T
G
E
G
P
F
Site 100
T857
G
P
P
P
R
S
A
T
G
E
G
P
F
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation