PhosphoNET

           
Protein Info 
   
Short Name:  FOXO3
Full Name:  Forkhead box protein O3
Alias:  AF6q21; AF6q21 protein; Fkhr2; Fkhrl1; Forkhead box O3; Forkhead box O3A; Forkhead in rhabdomyosarcoma-like 1; FOXO2; Foxo3; Foxo3a
Type:  Transcription protein
Mass (Da):  71277
Number AA:  673
UniProt ID:  O43524
International Prot ID:  IPI00012856
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0019901  GO:0043565  GO:0016563 PhosphoSite+ KinaseNET
Biological Process:  GO:0006915  GO:0045648  GO:0045944 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MAEAPASPAPLSPL
Site 2S12PASPAPLSPLEVELD
Site 3S26DPEFEPQSRPRSCTW
Site 4S30EPQSRPRSCTWPLQR
Site 5T32QSRPRSCTWPLQRPE
Site 6S43QRPELQASPAKPSGE
Site 7S55SGETAADSMIPEEED
Site 8S75DGGGRAGSAMAIGGG
Site 9S110PGGQDPGSGPATAAG
Site 10T114DPGSGPATAAGGLSG
Site 11S151SGQPRKCSSRRNAWG
Site 12S152GQPRKCSSRRNAWGN
Site 13S161RNAWGNLSYADLITR
Site 14T167LSYADLITRAIESSP
Site 15S173ITRAIESSPDKRLTL
Site 16T179SSPDKRLTLSQIYEW
Site 17S181PDKRLTLSQIYEWMV
Site 18Y184RLTLSQIYEWMVRCV
Site 19Y193WMVRCVPYFKDKGDS
Site 20S200YFKDKGDSNSSAGWK
Site 21S202KDKGDSNSSAGWKNS
Site 22S209SSAGWKNSIRHNLSL
Site 23S215NSIRHNLSLHSRFMR
Site 24S231QNEGTGKSSWWIINP
Site 25S232NEGTGKSSWWIINPD
Site 26S243INPDGGKSGKAPRRR
Site 27S253APRRRAVSMDNSNKY
Site 28S257RAVSMDNSNKYTKSR
Site 29Y260SMDNSNKYTKSRGRA
Site 30T261MDNSNKYTKSRGRAA
Site 31S263NSNKYTKSRGRAAKK
Site 32S280ALQTAPESADDSPSQ
Site 33S284APESADDSPSQLSKW
Site 34S286ESADDSPSQLSKWPG
Site 35S289DDSPSQLSKWPGSPT
Site 36S294QLSKWPGSPTSRSSD
Site 37T296SKWPGSPTSRSSDEL
Site 38S297KWPGSPTSRSSDELD
Site 39S299PGSPTSRSSDELDAW
Site 40S300GSPTSRSSDELDAWT
Site 41T307SDELDAWTDFRSRTN
Site 42S311DAWTDFRSRTNSNAS
Site 43T313WTDFRSRTNSNASTV
Site 44S315DFRSRTNSNASTVSG
Site 45S318SRTNSNASTVSGRLS
Site 46T319RTNSNASTVSGRLSP
Site 47S321NSNASTVSGRLSPIM
Site 48S325STVSGRLSPIMASTE
Site 49S344QDDDAPLSPMLYSSS
Site 50S349PLSPMLYSSSASLSP
Site 51S350LSPMLYSSSASLSPS
Site 52S351SPMLYSSSASLSPSV
Site 53S353MLYSSSASLSPSVSK
Site 54S355YSSSASLSPSVSKPC
Site 55S357SSASLSPSVSKPCTV
Site 56T363PSVSKPCTVELPRLT
Site 57T370TVELPRLTDMAGTMN
Site 58T383MNLNDGLTENLMDDL
Site 59T395DDLLDNITLPPSQPS
Site 60S399DNITLPPSQPSPTGG
Site 61S402TLPPSQPSPTGGLMQ
Site 62S411TGGLMQRSSSFPYTT
Site 63S412GGLMQRSSSFPYTTK
Site 64S413GLMQRSSSFPYTTKG
Site 65Y416QRSSSFPYTTKGSGL
Site 66T417RSSSFPYTTKGSGLG
Site 67T418SSSFPYTTKGSGLGS
Site 68S421FPYTTKGSGLGSPTS
Site 69S425TKGSGLGSPTSSFNS
Site 70T427GSGLGSPTSSFNSTV
Site 71S428SGLGSPTSSFNSTVF
Site 72S429GLGSPTSSFNSTVFG
Site 73S432SPTSSFNSTVFGPSS
Site 74T433PTSSFNSTVFGPSSL
Site 75S438NSTVFGPSSLNSLRQ
Site 76S439STVFGPSSLNSLRQS
Site 77S442FGPSSLNSLRQSPMQ
Site 78S446SLNSLRQSPMQTIQE
Site 79T458IQENKPATFSSMSHY
Site 80S461NKPATFSSMSHYGNQ
Site 81Y465TFSSMSHYGNQTLQD
Site 82T469MSHYGNQTLQDLLTS
Site 83T475QTLQDLLTSDSLSHS
Site 84S476TLQDLLTSDSLSHSD
Site 85S478QDLLTSDSLSHSDVM
Site 86S482TSDSLSHSDVMMTQS
Site 87T487SHSDVMMTQSDPLMS
Site 88S489SDVMMTQSDPLMSQA
Site 89S494TQSDPLMSQASTAVS
Site 90S497DPLMSQASTAVSAQN
Site 91T498PLMSQASTAVSAQNS
Site 92S501SQASTAVSAQNSRRN
Site 93S505TAVSAQNSRRNVMLR
Site 94S518LRNDPMMSFAAQPNQ
Site 95S547TQGALGGSRALSNSV
Site 96S551LGGSRALSNSVSNMG
Site 97S553GSRALSNSVSNMGLS
Site 98S555RALSNSVSNMGLSES
Site 99S560SVSNMGLSESSSLGS
Site 100S562SNMGLSESSSLGSAK
Site 101S564MGLSESSSLGSAKHQ
Site 102S567SESSSLGSAKHQQQS
Site 103S574SAKHQQQSPVSQSMQ
Site 104S577HQQQSPVSQSMQTLS
Site 105T582PVSQSMQTLSDSLSG
Site 106S584SQSMQTLSDSLSGSS
Site 107S586SMQTLSDSLSGSSLY
Site 108S588QTLSDSLSGSSLYST
Site 109S590LSDSLSGSSLYSTSA
Site 110S591SDSLSGSSLYSTSAN
Site 111T595SGSSLYSTSANLPVM
Site 112S609MGHEKFPSDLDLDMF
Site 113S619DLDMFNGSLECDMES
Site 114S626SLECDMESIIRSELM
Site 115S630DMESIIRSELMDADG
Site 116S644GLDFNFDSLISTQNV
Site 117S667TGAKQASSQSWVPG_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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