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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MBTPS2
Full Name:
Membrane-bound transcription factor site-2 protease
Alias:
Endopeptidase S2P;Sterol regulatory element-binding proteins intramembrane protease
Type:
Mass (Da):
57444
Number AA:
519
UniProt ID:
O43462
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
T
D
L
V
L
K
S
S
V
Y
F
K
H
S
Y
Site 2
Y29
L
V
L
K
S
S
V
Y
F
K
H
S
Y
E
D
Site 3
Y34
S
V
Y
F
K
H
S
Y
E
D
W
L
E
N
N
Site 4
S44
W
L
E
N
N
G
L
S
I
S
P
F
H
I
R
Site 5
S46
E
N
N
G
L
S
I
S
P
F
H
I
R
W
Q
Site 6
Y62
A
V
F
N
R
A
F
Y
S
W
G
R
R
K
A
Site 7
Y73
R
R
K
A
R
M
L
Y
Q
W
F
N
F
G
M
Site 8
S109
L
A
Q
M
M
A
D
S
P
S
S
Y
S
S
S
Site 9
S111
Q
M
M
A
D
S
P
S
S
Y
S
S
S
S
S
Site 10
S112
M
M
A
D
S
P
S
S
Y
S
S
S
S
S
S
Site 11
Y113
M
A
D
S
P
S
S
Y
S
S
S
S
S
S
S
Site 12
S114
A
D
S
P
S
S
Y
S
S
S
S
S
S
S
S
Site 13
S115
D
S
P
S
S
Y
S
S
S
S
S
S
S
S
S
Site 14
S116
S
P
S
S
Y
S
S
S
S
S
S
S
S
S
S
Site 15
S117
P
S
S
Y
S
S
S
S
S
S
S
S
S
S
S
Site 16
S118
S
S
Y
S
S
S
S
S
S
S
S
S
S
S
S
Site 17
S119
S
Y
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 18
S120
Y
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 19
S121
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 20
S130
S
S
S
S
S
S
S
S
S
S
S
S
S
S
L
Site 21
S131
S
S
S
S
S
S
S
S
S
S
S
S
S
L
H
Site 22
S132
S
S
S
S
S
S
S
S
S
S
S
S
L
H
N
Site 23
S133
S
S
S
S
S
S
S
S
S
S
S
L
H
N
E
Site 24
S134
S
S
S
S
S
S
S
S
S
S
L
H
N
E
Q
Site 25
S135
S
S
S
S
S
S
S
S
S
L
H
N
E
Q
V
Site 26
S136
S
S
S
S
S
S
S
S
L
H
N
E
Q
V
L
Site 27
S265
I
T
E
V
A
E
D
S
P
A
I
G
P
R
G
Site 28
Y302
E
C
L
D
T
I
A
Y
E
P
Q
I
G
Y
C
Site 29
S319
A
S
T
L
Q
Q
L
S
F
P
V
R
A
Y
K
Site 30
Y325
L
S
F
P
V
R
A
Y
K
R
L
D
G
S
T
Site 31
Y347
L
T
D
V
C
F
S
Y
R
N
N
F
N
K
R
Site 32
T357
N
F
N
K
R
L
H
T
C
L
P
A
R
K
A
Site 33
S380
T
N
K
D
C
K
K
S
S
S
S
S
F
C
I
Site 34
S381
N
K
D
C
K
K
S
S
S
S
S
F
C
I
I
Site 35
S382
K
D
C
K
K
S
S
S
S
S
F
C
I
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation