PhosphoNET

           
Protein Info 
   
Short Name:  MBTPS2
Full Name:  Membrane-bound transcription factor site-2 protease
Alias:  Endopeptidase S2P;Sterol regulatory element-binding proteins intramembrane protease
Type: 
Mass (Da):  57444
Number AA:  519
UniProt ID:  O43462
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S27TDLVLKSSVYFKHSY
Site 2Y29LVLKSSVYFKHSYED
Site 3Y34SVYFKHSYEDWLENN
Site 4S44WLENNGLSISPFHIR
Site 5S46ENNGLSISPFHIRWQ
Site 6Y62AVFNRAFYSWGRRKA
Site 7Y73RRKARMLYQWFNFGM
Site 8S109LAQMMADSPSSYSSS
Site 9S111QMMADSPSSYSSSSS
Site 10S112MMADSPSSYSSSSSS
Site 11Y113MADSPSSYSSSSSSS
Site 12S114ADSPSSYSSSSSSSS
Site 13S115DSPSSYSSSSSSSSS
Site 14S116SPSSYSSSSSSSSSS
Site 15S117PSSYSSSSSSSSSSS
Site 16S118SSYSSSSSSSSSSSS
Site 17S119SYSSSSSSSSSSSSS
Site 18S120YSSSSSSSSSSSSSS
Site 19S121SSSSSSSSSSSSSSS
Site 20S130SSSSSSSSSSSSSSL
Site 21S131SSSSSSSSSSSSSLH
Site 22S132SSSSSSSSSSSSLHN
Site 23S133SSSSSSSSSSSLHNE
Site 24S134SSSSSSSSSSLHNEQ
Site 25S135SSSSSSSSSLHNEQV
Site 26S136SSSSSSSSLHNEQVL
Site 27S265ITEVAEDSPAIGPRG
Site 28Y302ECLDTIAYEPQIGYC
Site 29S319ASTLQQLSFPVRAYK
Site 30Y325LSFPVRAYKRLDGST
Site 31Y347LTDVCFSYRNNFNKR
Site 32T357NFNKRLHTCLPARKA
Site 33S380TNKDCKKSSSSSFCI
Site 34S381NKDCKKSSSSSFCII
Site 35S382KDCKKSSSSSFCIIP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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