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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKRIR
Full Name:
52 kDa repressor of the inhibitor of the protein kinase
Alias:
58 kDa interferon-induced protein kinase-interacting protein;Death-associated protein 4;THAP domain-containing protein 0
Type:
Mass (Da):
87704
Number AA:
761
UniProt ID:
O43422
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
P
N
C
T
R
K
S
T
Q
S
D
L
A
F
Site 2
T15
P
N
C
T
R
K
S
T
Q
S
D
L
A
F
F
Site 3
S17
C
T
R
K
S
T
Q
S
D
L
A
F
F
R
F
Site 4
T47
R
A
D
L
E
D
K
T
P
D
Q
L
N
K
H
Site 5
S71
T
S
M
I
C
R
T
S
P
Y
R
T
V
L
R
Site 6
T75
C
R
T
S
P
Y
R
T
V
L
R
D
N
A
I
Site 7
T89
I
P
T
I
F
D
L
T
S
H
L
N
N
P
H
Site 8
S90
P
T
I
F
D
L
T
S
H
L
N
N
P
H
S
Site 9
S97
S
H
L
N
N
P
H
S
R
H
R
K
R
I
K
Site 10
S107
R
K
R
I
K
E
L
S
E
D
E
I
R
T
L
Site 11
T122
K
Q
K
K
I
D
E
T
S
E
Q
E
Q
K
H
Site 12
S123
Q
K
K
I
D
E
T
S
E
Q
E
Q
K
H
K
Site 13
S135
K
H
K
E
T
N
N
S
N
A
Q
N
P
S
E
Site 14
T156
D
E
D
I
L
P
L
T
L
E
E
K
E
N
K
Site 15
Y165
E
E
K
E
N
K
E
Y
L
K
S
L
F
E
I
Site 16
T197
E
I
P
E
G
L
F
T
P
D
N
F
Q
A
L
Site 17
S211
L
L
E
C
R
I
N
S
G
E
E
V
L
R
K
Site 18
T233
N
T
L
F
C
S
K
T
Q
Q
R
Q
M
L
E
Site 19
T250
E
S
C
I
R
E
E
T
L
R
E
V
R
D
S
Site 20
S257
T
L
R
E
V
R
D
S
H
F
F
S
I
I
T
Site 21
S286
L
V
R
F
V
D
E
S
H
N
L
R
E
E
F
Site 22
Y330
E
Y
C
R
G
Q
A
Y
I
V
S
S
G
F
S
Site 23
S333
R
G
Q
A
Y
I
V
S
S
G
F
S
S
K
M
Site 24
S334
G
Q
A
Y
I
V
S
S
G
F
S
S
K
M
K
Site 25
S345
S
K
M
K
V
V
A
S
R
L
L
E
K
Y
P
Site 26
Y351
A
S
R
L
L
E
K
Y
P
Q
A
I
Y
T
L
Site 27
Y356
E
K
Y
P
Q
A
I
Y
T
L
C
S
S
C
A
Site 28
S389
G
T
I
E
E
V
C
S
F
F
H
R
S
P
Q
Site 29
Y462
T
N
I
R
W
N
N
Y
I
A
G
R
A
F
V
Site 30
S505
K
N
L
Q
G
Q
T
S
D
V
F
F
A
A
G
Site 31
S566
A
H
Q
G
N
L
E
S
Q
L
T
S
E
S
Y
Site 32
T569
G
N
L
E
S
Q
L
T
S
E
S
Y
Y
K
E
Site 33
S570
N
L
E
S
Q
L
T
S
E
S
Y
Y
K
E
T
Site 34
S572
E
S
Q
L
T
S
E
S
Y
Y
K
E
T
L
S
Site 35
Y573
S
Q
L
T
S
E
S
Y
Y
K
E
T
L
S
V
Site 36
Y574
Q
L
T
S
E
S
Y
Y
K
E
T
L
S
V
P
Site 37
S579
S
Y
Y
K
E
T
L
S
V
P
T
V
E
H
I
Site 38
S595
Q
E
L
K
D
I
F
S
E
Q
H
L
K
A
L
Site 39
S606
L
K
A
L
K
C
L
S
L
V
P
S
V
M
G
Site 40
S610
K
C
L
S
L
V
P
S
V
M
G
Q
L
K
F
Site 41
S620
G
Q
L
K
F
N
T
S
E
E
H
H
A
D
M
Site 42
Y628
E
E
H
H
A
D
M
Y
R
S
D
L
P
N
P
Site 43
T637
S
D
L
P
N
P
D
T
L
S
A
E
L
H
C
Site 44
S639
L
P
N
P
D
T
L
S
A
E
L
H
C
W
R
Site 45
S660
G
K
D
I
E
L
P
S
T
I
Y
E
A
L
H
Site 46
T661
K
D
I
E
L
P
S
T
I
Y
E
A
L
H
L
Site 47
Y697
M
K
V
E
N
E
R
Y
E
N
G
R
K
R
L
Site 48
Y707
G
R
K
R
L
K
A
Y
L
R
N
T
L
T
D
Site 49
T711
L
K
A
Y
L
R
N
T
L
T
D
Q
R
S
S
Site 50
T713
A
Y
L
R
N
T
L
T
D
Q
R
S
S
N
L
Site 51
S717
N
T
L
T
D
Q
R
S
S
N
L
A
L
L
N
Site 52
S718
T
L
T
D
Q
R
S
S
N
L
A
L
L
N
I
Site 53
Y744
V
D
T
Y
I
K
L
Y
T
S
K
S
E
L
P
Site 54
S748
I
K
L
Y
T
S
K
S
E
L
P
T
D
N
S
Site 55
T752
T
S
K
S
E
L
P
T
D
N
S
E
T
V
E
Site 56
S755
S
E
L
P
T
D
N
S
E
T
V
E
N
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation