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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EFS
Full Name:
Embryonal Fyn-associated substrate
Alias:
Cas scaffolding protein family member 3; CASS3; EFS1; EFS2; HEFS; SIN
Type:
Adaptor/scaffold
Mass (Da):
58815
Number AA:
561
UniProt ID:
O43281
International Prot ID:
IPI00011652
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
T
Q
L
A
R
A
L
Y
D
N
T
A
E
S
P
Site 2
S20
L
Y
D
N
T
A
E
S
P
Q
E
L
S
F
R
Site 3
S25
A
E
S
P
Q
E
L
S
F
R
R
G
D
V
L
Site 4
S75
A
G
P
A
P
K
P
S
L
S
P
A
S
P
A
Site 5
S77
P
A
P
K
P
S
L
S
P
A
S
P
A
Q
P
Site 6
S80
K
P
S
L
S
P
A
S
P
A
Q
P
G
S
P
Site 7
S86
A
S
P
A
Q
P
G
S
P
Y
P
A
P
D
H
Site 8
Y88
P
A
Q
P
G
S
P
Y
P
A
P
D
H
S
N
Site 9
S94
P
Y
P
A
P
D
H
S
N
E
D
Q
E
V
Y
Site 10
Y101
S
N
E
D
Q
E
V
Y
V
V
P
P
P
A
R
Site 11
S113
P
A
R
P
C
P
T
S
G
P
P
A
G
P
C
Site 12
S123
P
A
G
P
C
P
P
S
P
D
L
I
Y
K
I
Site 13
Y128
P
P
S
P
D
L
I
Y
K
I
P
R
A
S
G
Site 14
S134
I
Y
K
I
P
R
A
S
G
T
Q
L
A
A
P
Site 15
Y148
P
R
D
A
L
E
V
Y
D
V
P
P
T
A
L
Site 16
T153
E
V
Y
D
V
P
P
T
A
L
R
V
P
S
S
Site 17
S159
P
T
A
L
R
V
P
S
S
G
P
Y
D
C
P
Site 18
S160
T
A
L
R
V
P
S
S
G
P
Y
D
C
P
A
Site 19
Y163
R
V
P
S
S
G
P
Y
D
C
P
A
S
F
S
Site 20
S168
G
P
Y
D
C
P
A
S
F
S
H
P
L
T
R
Site 21
S170
Y
D
C
P
A
S
F
S
H
P
L
T
R
V
A
Site 22
T174
A
S
F
S
H
P
L
T
R
V
A
P
Q
P
P
Site 23
Y188
P
G
E
D
D
A
P
Y
D
V
P
L
T
P
K
Site 24
T193
A
P
Y
D
V
P
L
T
P
K
P
P
A
E
L
Site 25
Y217
R
E
P
G
P
P
I
Y
A
A
P
S
N
L
K
Site 26
S221
P
P
I
Y
A
A
P
S
N
L
K
R
A
S
A
Site 27
S227
P
S
N
L
K
R
A
S
A
L
L
N
L
Y
E
Site 28
T248
A
D
G
E
G
G
G
T
D
E
G
I
Y
D
V
Site 29
Y253
G
G
T
D
E
G
I
Y
D
V
P
L
L
G
P
Site 30
S265
L
G
P
E
A
P
P
S
P
E
P
P
G
A
L
Site 31
S274
E
P
P
G
A
L
A
S
H
D
Q
D
T
L
A
Site 32
T279
L
A
S
H
D
Q
D
T
L
A
Q
L
L
A
R
Site 33
S287
L
A
Q
L
L
A
R
S
P
P
P
P
H
R
P
Site 34
S298
P
H
R
P
R
L
P
S
A
E
S
L
S
R
R
Site 35
S301
P
R
L
P
S
A
E
S
L
S
R
R
P
L
P
Site 36
S303
L
P
S
A
E
S
L
S
R
R
P
L
P
A
L
Site 37
S317
L
P
V
P
E
A
P
S
P
S
P
V
P
S
P
Site 38
S319
V
P
E
A
P
S
P
S
P
V
P
S
P
A
P
Site 39
S323
P
S
P
S
P
V
P
S
P
A
P
G
R
K
G
Site 40
S331
P
A
P
G
R
K
G
S
I
Q
D
R
P
L
P
Site 41
Y347
P
P
P
R
L
P
G
Y
G
G
P
K
V
E
G
Site 42
Y372
P
A
G
H
H
N
E
Y
E
G
I
P
M
A
E
Site 43
Y381
G
I
P
M
A
E
E
Y
D
Y
V
H
L
K
G
Site 44
Y383
P
M
A
E
E
Y
D
Y
V
H
L
K
G
M
D
Site 45
S395
G
M
D
K
A
Q
G
S
R
P
P
D
Q
A
C
Site 46
T403
R
P
P
D
Q
A
C
T
G
D
P
E
L
P
E
Site 47
Y437
T
G
D
L
Q
L
L
Y
F
Y
A
G
Q
C
Q
Site 48
Y447
A
G
Q
C
Q
S
H
Y
S
A
L
Q
A
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation