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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRODH
Full Name:
Proline dehydrogenase, mitochondrial
Alias:
EC 1.5.99.8; HSPOX2; P53-induced gene 6 protein; PIG6; Pproline oxidase 2; PROD; PRODH1; PRODH2; Proline dehydrogenase; Proline dehydrogenase (oxidase) 1; Proline oxidase; Proline oxidase 2; Proline oxidase, mitochondrial; TP53I6
Type:
Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.5.99.8
Mass (Da):
59231
Number AA:
516
UniProt ID:
O43272
International Prot ID:
IPI00383798
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004657
PhosphoSite+
KinaseNET
Biological Process:
GO:0006537
GO:0008631
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
M
R
E
W
K
K
S
R
K
L
L
G
Q
R
Site 2
S41
V
A
G
E
D
Q
E
S
I
Q
P
L
L
R
H
Site 3
S67
Y
G
V
E
E
D
L
S
P
E
E
A
E
H
K
Site 4
S81
K
E
M
E
S
C
T
S
A
A
E
R
D
G
S
Site 5
S88
S
A
A
E
R
D
G
S
G
T
N
K
R
D
K
Site 6
T90
A
E
R
D
G
S
G
T
N
K
R
D
K
Q
Y
Site 7
Y97
T
N
K
R
D
K
Q
Y
Q
A
H
R
A
F
G
Site 8
S112
D
R
R
N
G
V
I
S
A
R
T
Y
F
Y
A
Site 9
Y116
G
V
I
S
A
R
T
Y
F
Y
A
N
E
A
K
Site 10
S138
F
L
R
C
I
E
A
S
G
R
V
S
D
D
G
Site 11
T221
E
D
W
F
T
A
E
T
L
G
V
S
G
T
M
Site 12
S235
M
D
L
L
D
W
S
S
L
I
D
S
R
T
K
Site 13
S239
D
W
S
S
L
I
D
S
R
T
K
L
S
K
H
Site 14
T241
S
S
L
I
D
S
R
T
K
L
S
K
H
L
V
Site 15
S262
G
Q
L
E
P
L
L
S
R
F
T
E
E
E
E
Site 16
T265
E
P
L
L
S
R
F
T
E
E
E
E
L
Q
M
Site 17
T273
E
E
E
E
L
Q
M
T
R
M
L
Q
R
M
D
Site 18
Y301
M
V
D
A
E
Q
T
Y
F
Q
P
A
I
S
R
Site 19
T310
Q
P
A
I
S
R
L
T
L
E
M
Q
R
K
F
Site 20
Y328
K
P
L
I
F
N
T
Y
Q
C
Y
L
K
D
A
Site 21
Y336
Q
C
Y
L
K
D
A
Y
D
N
V
T
L
D
V
Site 22
T340
K
D
A
Y
D
N
V
T
L
D
V
E
L
A
R
Site 23
Y362
A
K
L
V
R
G
A
Y
L
A
Q
E
R
A
R
Site 24
Y375
A
R
A
A
E
I
G
Y
E
D
P
I
N
P
T
Site 25
Y383
E
D
P
I
N
P
T
Y
E
A
T
N
A
M
Y
Site 26
Y390
Y
E
A
T
N
A
M
Y
H
R
C
L
D
Y
V
Site 27
Y396
M
Y
H
R
C
L
D
Y
V
L
E
E
L
K
H
Site 28
T418
V
A
S
H
N
E
D
T
V
R
F
A
L
R
R
Site 29
Y439
H
P
A
D
H
Q
V
Y
F
G
Q
L
L
G
M
Site 30
Y459
F
P
L
G
Q
A
G
Y
P
V
Y
K
Y
V
P
Site 31
Y462
G
Q
A
G
Y
P
V
Y
K
Y
V
P
Y
G
P
Site 32
S478
M
E
V
L
P
Y
L
S
R
R
A
L
E
N
S
Site 33
S485
S
R
R
A
L
E
N
S
S
L
M
K
G
T
H
Site 34
S486
R
R
A
L
E
N
S
S
L
M
K
G
T
H
R
Site 35
T508
E
L
L
R
R
L
R
T
G
N
L
F
H
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation