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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EAN57
Full Name:
Protein EAN57
Alias:
Type:
Mass (Da):
30725
Number AA:
280
UniProt ID:
O43247
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
G
H
G
A
G
T
T
T
F
T
R
A
H
L
N
Site 2
S34
D
P
W
K
A
A
Y
S
S
L
D
T
S
K
F
Site 3
S35
P
W
K
A
A
Y
S
S
L
D
T
S
K
F
K
Site 4
T38
A
A
Y
S
S
L
D
T
S
K
F
K
N
Q
G
Site 5
S39
A
Y
S
S
L
D
T
S
K
F
K
N
Q
G
L
Site 6
S47
K
F
K
N
Q
G
L
S
S
P
Q
P
L
P
L
Site 7
S48
F
K
N
Q
G
L
S
S
P
Q
P
L
P
L
G
Site 8
S57
Q
P
L
P
L
G
A
S
A
Q
G
S
S
L
G
Site 9
T77
E
I
P
P
P
P
P
T
A
A
S
R
D
S
L
Site 10
S80
P
P
P
P
T
A
A
S
R
D
S
L
G
M
D
Site 11
S83
P
T
A
A
S
R
D
S
L
G
M
D
P
Q
S
Site 12
S90
S
L
G
M
D
P
Q
S
R
S
L
K
N
A
G
Site 13
S92
G
M
D
P
Q
S
R
S
L
K
N
A
G
S
R
Site 14
S98
R
S
L
K
N
A
G
S
R
S
S
S
R
E
N
Site 15
S100
L
K
N
A
G
S
R
S
S
S
R
E
N
R
A
Site 16
S101
K
N
A
G
S
R
S
S
S
R
E
N
R
A
T
Site 17
S102
N
A
G
S
R
S
S
S
R
E
N
R
A
T
S
Site 18
T108
S
S
R
E
N
R
A
T
S
G
E
G
A
Q
P
Site 19
S109
S
R
E
N
R
A
T
S
G
E
G
A
Q
P
C
Site 20
S124
Q
G
T
D
D
G
P
S
L
G
A
Q
D
Q
R
Site 21
S132
L
G
A
Q
D
Q
R
S
T
P
T
N
Q
K
G
Site 22
T133
G
A
Q
D
Q
R
S
T
P
T
N
Q
K
G
S
Site 23
S152
N
I
R
H
K
F
G
S
N
V
V
D
Q
L
V
Site 24
S179
F
E
G
Q
K
R
A
S
S
W
P
S
R
T
Q
Site 25
S180
E
G
Q
K
R
A
S
S
W
P
S
R
T
Q
N
Site 26
S183
K
R
A
S
S
W
P
S
R
T
Q
N
P
V
E
Site 27
T185
A
S
S
W
P
S
R
T
Q
N
P
V
E
I
S
Site 28
S192
T
Q
N
P
V
E
I
S
S
V
F
S
D
Y
Y
Site 29
S193
Q
N
P
V
E
I
S
S
V
F
S
D
Y
Y
D
Site 30
S196
V
E
I
S
S
V
F
S
D
Y
Y
D
L
G
Y
Site 31
Y198
I
S
S
V
F
S
D
Y
Y
D
L
G
Y
N
M
Site 32
Y199
S
S
V
F
S
D
Y
Y
D
L
G
Y
N
M
R
Site 33
Y203
S
D
Y
Y
D
L
G
Y
N
M
R
S
N
L
F
Site 34
S219
G
A
A
E
E
T
K
S
L
M
K
A
S
Y
T
Site 35
S224
T
K
S
L
M
K
A
S
Y
T
P
E
V
I
E
Site 36
T226
S
L
M
K
A
S
Y
T
P
E
V
I
E
K
S
Site 37
S233
T
P
E
V
I
E
K
S
V
R
D
L
E
H
W
Site 38
Y269
Q
K
A
L
E
E
K
Y
G
E
N
S
K
S
K
Site 39
S273
E
E
K
Y
G
E
N
S
K
S
K
S
S
K
Y
Site 40
S275
K
Y
G
E
N
S
K
S
K
S
S
K
Y
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation