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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC7A4
Full Name:
Cationic amino acid transporter 4
Alias:
CAT4; CAT-4; CTR4; HCAT3; Solute carrier family 7 (cationic amino acid transporter, y+ system) member 4; Solute carrier family 7 member 4; VH
Type:
Mass (Da):
68249
Number AA:
635
UniProt ID:
O43246
International Prot ID:
IPI00748296
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0015174
PhosphoSite+
KinaseNET
Biological Process:
GO:0006865
GO:0006520
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
R
L
K
P
L
E
D
S
T
M
E
T
S
L
R
Site 2
T28
L
K
P
L
E
D
S
T
M
E
T
S
L
R
R
Site 3
T31
L
E
D
S
T
M
E
T
S
L
R
R
C
L
S
Site 4
S32
E
D
S
T
M
E
T
S
L
R
R
C
L
S
T
Site 5
Y56
G
M
V
G
S
G
L
Y
V
L
T
G
A
V
A
Site 6
Y140
V
A
R
A
W
S
G
Y
L
D
S
M
F
S
H
Site 7
S143
A
W
S
G
Y
L
D
S
M
F
S
H
S
I
R
Site 8
S146
G
Y
L
D
S
M
F
S
H
S
I
R
N
F
T
Site 9
S148
L
D
S
M
F
S
H
S
I
R
N
F
T
E
T
Site 10
T153
S
H
S
I
R
N
F
T
E
T
H
V
G
S
W
Site 11
T155
S
I
R
N
F
T
E
T
H
V
G
S
W
Q
V
Site 12
S192
S
C
G
A
R
V
S
S
W
L
N
H
T
F
S
Site 13
S223
L
A
Q
P
H
N
W
S
A
D
E
G
G
F
A
Site 14
S267
E
A
Q
N
P
R
R
S
V
P
L
A
I
A
I
Site 15
S303
W
H
S
L
D
P
D
S
A
L
A
D
A
F
Y
Site 16
Y310
S
A
L
A
D
A
F
Y
Q
R
G
Y
R
W
A
Site 17
Y314
D
A
F
Y
Q
R
G
Y
R
W
A
G
F
I
V
Site 18
T364
F
A
H
V
H
P
R
T
Q
V
P
V
A
G
T
Site 19
S417
I
V
L
R
F
Q
K
S
S
P
P
S
S
P
G
Site 20
S418
V
L
R
F
Q
K
S
S
P
P
S
S
P
G
P
Site 21
S421
F
Q
K
S
S
P
P
S
S
P
G
P
A
S
P
Site 22
S422
Q
K
S
S
P
P
S
S
P
G
P
A
S
P
G
Site 23
S427
P
S
S
P
G
P
A
S
P
G
P
L
T
K
Q
Site 24
T432
P
A
S
P
G
P
L
T
K
Q
Q
S
S
F
S
Site 25
S436
G
P
L
T
K
Q
Q
S
S
F
S
D
H
L
Q
Site 26
S437
P
L
T
K
Q
Q
S
S
F
S
D
H
L
Q
L
Site 27
S439
T
K
Q
Q
S
S
F
S
D
H
L
Q
L
V
G
Site 28
Y535
L
G
A
H
Q
Q
Q
Y
R
E
D
L
F
Q
I
Site 29
S590
F
G
Y
G
I
R
H
S
K
E
N
Q
R
E
L
Site 30
S602
R
E
L
P
G
L
N
S
T
H
Y
V
V
F
P
Site 31
Y605
P
G
L
N
S
T
H
Y
V
V
F
P
R
G
S
Site 32
S612
Y
V
V
F
P
R
G
S
L
E
E
T
V
Q
A
Site 33
T616
P
R
G
S
L
E
E
T
V
Q
A
M
Q
P
P
Site 34
S624
V
Q
A
M
Q
P
P
S
Q
A
P
A
Q
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation