KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MSH5
Full Name:
MutS protein homolog 5
Alias:
Type:
Mass (Da):
92875
Number AA:
834
UniProt ID:
O43196
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
L
G
A
N
P
R
R
T
P
Q
G
P
R
P
G
Site 2
S21
G
P
R
P
G
A
A
S
S
G
F
P
S
P
A
Site 3
S22
P
R
P
G
A
A
S
S
G
F
P
S
P
A
P
Site 4
S26
A
A
S
S
G
F
P
S
P
A
P
V
P
G
P
Site 5
Y65
S
G
Y
L
G
I
A
Y
Y
D
T
S
D
S
T
Site 6
Y66
G
Y
L
G
I
A
Y
Y
D
T
S
D
S
T
I
Site 7
T68
L
G
I
A
Y
Y
D
T
S
D
S
T
I
H
F
Site 8
S84
P
D
A
P
D
H
E
S
L
K
L
L
Q
R
V
Site 9
S99
L
D
E
I
N
P
Q
S
V
V
T
S
A
K
Q
Site 10
S103
N
P
Q
S
V
V
T
S
A
K
Q
D
E
N
M
Site 11
S119
R
F
L
G
K
L
A
S
Q
E
H
R
E
P
K
Site 12
S143
V
D
F
G
L
E
I
S
K
Q
R
L
L
S
G
Site 13
S149
I
S
K
Q
R
L
L
S
G
N
Y
S
F
I
P
Site 14
Y152
Q
R
L
L
S
G
N
Y
S
F
I
P
D
A
M
Site 15
S153
R
L
L
S
G
N
Y
S
F
I
P
D
A
M
T
Site 16
T162
I
P
D
A
M
T
A
T
E
K
I
L
F
L
S
Site 17
Y227
V
N
I
D
Q
D
T
Y
S
V
L
Q
I
F
K
Site 18
S228
N
I
D
Q
D
T
Y
S
V
L
Q
I
F
K
S
Site 19
S235
S
V
L
Q
I
F
K
S
E
S
H
P
S
V
Y
Site 20
S237
L
Q
I
F
K
S
E
S
H
P
S
V
Y
K
V
Site 21
S240
F
K
S
E
S
H
P
S
V
Y
K
V
A
S
G
Site 22
Y242
S
E
S
H
P
S
V
Y
K
V
A
S
G
L
K
Site 23
S246
P
S
V
Y
K
V
A
S
G
L
K
E
G
L
S
Site 24
T278
R
L
W
F
T
R
P
T
H
D
L
G
E
L
S
Site 25
S286
H
D
L
G
E
L
S
S
R
L
D
V
I
Q
F
Site 26
S326
I
L
K
R
M
K
L
S
H
T
K
V
S
D
W
Site 27
S352
G
L
R
D
A
C
R
S
L
P
Q
S
I
Q
L
Site 28
S356
A
C
R
S
L
P
Q
S
I
Q
L
F
R
D
I
Site 29
S368
R
D
I
A
Q
E
F
S
D
D
L
H
H
I
A
Site 30
S387
K
V
V
D
F
E
G
S
L
A
E
N
R
F
T
Site 31
T394
S
L
A
E
N
R
F
T
V
L
P
N
I
D
P
Site 32
S430
K
E
L
E
N
L
D
S
R
I
P
S
C
S
V
Site 33
S472
G
L
D
F
M
F
L
S
E
E
K
L
H
Y
R
Site 34
Y478
L
S
E
E
K
L
H
Y
R
S
A
R
T
K
E
Site 35
S480
E
E
K
L
H
Y
R
S
A
R
T
K
E
L
D
Site 36
Y542
L
A
S
A
A
R
D
Y
G
Y
S
R
P
R
Y
Site 37
Y544
S
A
A
R
D
Y
G
Y
S
R
P
R
Y
S
P
Site 38
S545
A
A
R
D
Y
G
Y
S
R
P
R
Y
S
P
Q
Site 39
Y549
Y
G
Y
S
R
P
R
Y
S
P
Q
V
L
G
V
Site 40
S550
G
Y
S
R
P
R
Y
S
P
Q
V
L
G
V
R
Site 41
S577
A
R
T
F
V
P
N
S
T
E
C
G
G
D
K
Site 42
T591
K
G
R
V
K
V
I
T
G
P
N
S
S
G
K
Site 43
S595
K
V
I
T
G
P
N
S
S
G
K
S
I
Y
L
Site 44
S596
V
I
T
G
P
N
S
S
G
K
S
I
Y
L
K
Site 45
S599
G
P
N
S
S
G
K
S
I
Y
L
K
Q
V
G
Site 46
Y601
N
S
S
G
K
S
I
Y
L
K
Q
V
G
L
I
Site 47
S640
T
R
I
H
S
C
E
S
I
S
L
G
L
S
T
Site 48
Y726
P
Q
G
P
L
V
Q
Y
L
T
M
E
T
C
E
Site 49
T728
G
P
L
V
Q
Y
L
T
M
E
T
C
E
D
G
Site 50
S775
V
A
R
G
K
E
V
S
D
L
I
R
S
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation