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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRX
Full Name:
Cone-rod homeobox protein
Alias:
Type:
Mass (Da):
32261
Number AA:
299
UniProt ID:
O43186
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
Y
M
N
P
G
P
H
Y
S
V
N
A
L
A
L
Site 2
S12
M
N
P
G
P
H
Y
S
V
N
A
L
A
L
S
Site 3
Y32
L
M
H
Q
A
V
P
Y
P
S
A
P
R
K
Q
Site 4
S34
H
Q
A
V
P
Y
P
S
A
P
R
K
Q
R
R
Site 5
T44
R
K
Q
R
R
E
R
T
T
F
T
R
S
Q
L
Site 6
T45
K
Q
R
R
E
R
T
T
F
T
R
S
Q
L
E
Site 7
S49
E
R
T
T
F
T
R
S
Q
L
E
E
L
E
A
Site 8
Y63
A
L
F
A
K
T
Q
Y
P
D
V
Y
A
R
E
Site 9
Y67
K
T
Q
Y
P
D
V
Y
A
R
E
E
V
A
L
Site 10
S81
L
K
I
N
L
P
E
S
R
V
Q
V
W
F
K
Site 11
S124
A
K
R
K
A
G
T
S
P
R
P
S
T
D
V
Site 12
S128
A
G
T
S
P
R
P
S
T
D
V
C
P
D
P
Site 13
T129
G
T
S
P
R
P
S
T
D
V
C
P
D
P
L
Site 14
S139
C
P
D
P
L
G
I
S
D
S
Y
S
P
P
L
Site 15
S141
D
P
L
G
I
S
D
S
Y
S
P
P
L
P
G
Site 16
Y142
P
L
G
I
S
D
S
Y
S
P
P
L
P
G
P
Site 17
S143
L
G
I
S
D
S
Y
S
P
P
L
P
G
P
S
Site 18
S150
S
P
P
L
P
G
P
S
G
S
P
T
T
A
V
Site 19
S152
P
L
P
G
P
S
G
S
P
T
T
A
V
A
T
Site 20
T154
P
G
P
S
G
S
P
T
T
A
V
A
T
V
S
Site 21
S167
V
S
I
W
S
P
A
S
E
S
P
L
P
E
A
Site 22
S169
I
W
S
P
A
S
E
S
P
L
P
E
A
Q
R
Site 23
S188
A
S
G
P
S
L
T
S
A
P
Y
A
M
T
Y
Site 24
S203
A
P
A
S
A
F
C
S
S
P
S
A
Y
G
S
Site 25
S204
P
A
S
A
F
C
S
S
P
S
A
Y
G
S
P
Site 26
S206
S
A
F
C
S
S
P
S
A
Y
G
S
P
S
S
Site 27
Y208
F
C
S
S
P
S
A
Y
G
S
P
S
S
Y
F
Site 28
S210
S
S
P
S
A
Y
G
S
P
S
S
Y
F
S
G
Site 29
S212
P
S
A
Y
G
S
P
S
S
Y
F
S
G
L
D
Site 30
S213
S
A
Y
G
S
P
S
S
Y
F
S
G
L
D
P
Site 31
Y214
A
Y
G
S
P
S
S
Y
F
S
G
L
D
P
Y
Site 32
S216
G
S
P
S
S
Y
F
S
G
L
D
P
Y
L
S
Site 33
Y221
Y
F
S
G
L
D
P
Y
L
S
P
M
V
P
Q
Site 34
S223
S
G
L
D
P
Y
L
S
P
M
V
P
Q
L
G
Site 35
S238
G
P
A
L
S
P
L
S
G
P
S
V
G
P
S
Site 36
S245
S
G
P
S
V
G
P
S
L
A
Q
S
P
T
S
Site 37
S249
V
G
P
S
L
A
Q
S
P
T
S
L
S
G
Q
Site 38
T251
P
S
L
A
Q
S
P
T
S
L
S
G
Q
S
Y
Site 39
S252
S
L
A
Q
S
P
T
S
L
S
G
Q
S
Y
G
Site 40
S254
A
Q
S
P
T
S
L
S
G
Q
S
Y
G
A
Y
Site 41
Y258
T
S
L
S
G
Q
S
Y
G
A
Y
S
P
V
D
Site 42
Y261
S
G
Q
S
Y
G
A
Y
S
P
V
D
S
L
E
Site 43
S262
G
Q
S
Y
G
A
Y
S
P
V
D
S
L
E
F
Site 44
S266
G
A
Y
S
P
V
D
S
L
E
F
K
D
P
T
Site 45
T273
S
L
E
F
K
D
P
T
G
T
W
K
F
T
Y
Site 46
Y280
T
G
T
W
K
F
T
Y
N
P
M
D
P
L
D
Site 47
Y288
N
P
M
D
P
L
D
Y
K
D
Q
S
A
W
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation