KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PHGDH
Full Name:
D-3-phosphoglycerate dehydrogenase
Alias:
3PGDH; 3-PGDH; EC 1.1.1.95; PDG; PGAD; PGD; PGDH; PGDH3; Phosphoglycerate dehydrogenase; SERA
Type:
Enzyme, dehydrogenase
Mass (Da):
56651
Number AA:
533
UniProt ID:
O43175
International Prot ID:
IPI00011200
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0051287
GO:0009055
GO:0004617
PhosphoSite+
KinaseNET
Biological Process:
GO:0006564
GO:0007420
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
K
V
L
I
S
D
S
L
D
P
C
C
R
K
Site 2
S37
V
V
E
K
Q
N
L
S
K
E
E
L
I
A
E
Site 3
T78
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
Site 4
T89
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
Site 5
T98
K
G
I
L
V
M
N
T
P
N
G
N
S
L
S
Site 6
S105
T
P
N
G
N
S
L
S
A
A
E
L
T
C
G
Site 7
T125
A
R
Q
I
P
Q
A
T
A
S
M
K
D
G
K
Site 8
S127
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
Site 9
T141
E
R
K
K
F
M
G
T
E
L
N
G
K
T
L
Site 10
S166
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Site 11
Y174
F
G
M
K
T
I
G
Y
D
P
I
I
S
P
E
Site 12
S179
I
G
Y
D
P
I
I
S
P
E
V
S
A
S
F
Site 13
T221
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
Site 14
T263
G
A
A
L
D
V
F
T
E
E
P
P
R
D
R
Site 15
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Site 16
S287
S
C
P
H
L
G
A
S
T
K
E
A
Q
S
R
Site 17
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Site 18
S326
Q
A
L
T
S
A
F
S
P
H
T
K
P
W
I
Site 19
S349
L
M
R
A
W
A
G
S
P
K
G
T
I
Q
V
Site 20
T353
W
A
G
S
P
K
G
T
I
Q
V
I
T
Q
G
Site 21
T358
K
G
T
I
Q
V
I
T
Q
G
T
S
L
K
N
Site 22
S371
K
N
A
G
N
C
L
S
P
A
V
I
V
G
L
Site 23
S383
V
G
L
L
K
E
A
S
K
Q
A
D
V
N
L
Site 24
T405
K
E
A
G
L
N
V
T
T
S
H
S
P
A
A
Site 25
S407
A
G
L
N
V
T
T
S
H
S
P
A
A
P
G
Site 26
S409
L
N
V
T
T
S
H
S
P
A
A
P
G
E
Q
Site 27
T480
S
D
P
A
M
L
P
T
M
I
G
L
L
A
E
Site 28
S498
R
L
L
S
Y
Q
T
S
L
V
S
D
G
E
T
Site 29
S501
S
Y
Q
T
S
L
V
S
D
G
E
T
W
H
V
Site 30
S517
G
I
S
S
L
L
P
S
L
E
A
W
K
Q
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation