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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF4
Full Name:
U4/U6 small nuclear ribonucleoprotein Prp4
Alias:
U4/U6 snRNP 60 kDa protein
Type:
Mass (Da):
58431
Number AA:
522
UniProt ID:
O43172
International Prot ID:
IPI00150269
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0016604
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0031202
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
S
R
A
S
S
T
Q
A
T
K
T
Site 2
S8
M
A
S
S
R
A
S
S
T
Q
A
T
K
T
K
Site 3
T12
R
A
S
S
T
Q
A
T
K
T
K
A
P
D
D
Site 4
T14
S
S
T
Q
A
T
K
T
K
A
P
D
D
L
V
Site 5
Y31
V
V
K
K
P
H
I
Y
Y
G
S
L
E
E
K
Site 6
Y32
V
K
K
P
H
I
Y
Y
G
S
L
E
E
K
E
Site 7
S34
K
P
H
I
Y
Y
G
S
L
E
E
K
E
R
E
Site 8
S80
F
E
I
E
E
H
I
S
E
R
Q
A
E
V
L
Site 9
S102
R
A
R
Q
I
N
V
S
T
D
D
S
E
V
K
Site 10
S106
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Site 11
T142
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Site 12
S155
T
K
K
D
D
E
K
S
K
K
S
K
E
E
Y
Site 13
Y162
S
K
K
S
K
E
E
Y
Q
Q
T
W
Y
H
E
Site 14
Y167
E
E
Y
Q
Q
T
W
Y
H
E
G
P
N
S
L
Site 15
Y184
A
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
Site 16
S185
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Site 17
T205
L
H
K
E
I
P
E
T
T
R
T
S
Q
M
Q
Site 18
T208
E
I
P
E
T
T
R
T
S
Q
M
Q
E
L
H
Site 19
S209
I
P
E
T
T
R
T
S
Q
M
Q
E
L
H
K
Site 20
S217
Q
M
Q
E
L
H
K
S
L
R
S
L
N
N
F
Site 21
S220
E
L
H
K
S
L
R
S
L
N
N
F
C
S
Q
Site 22
S226
R
S
L
N
N
F
C
S
Q
I
G
D
D
R
P
Site 23
Y236
G
D
D
R
P
I
S
Y
C
H
F
S
P
N
S
Site 24
S240
P
I
S
Y
C
H
F
S
P
N
S
K
M
L
A
Site 25
T268
P
D
C
N
L
L
H
T
L
R
G
H
N
T
N
Site 26
S285
A
I
V
F
H
P
K
S
T
V
S
L
D
P
K
Site 27
S288
F
H
P
K
S
T
V
S
L
D
P
K
D
V
N
Site 28
S298
P
K
D
V
N
L
A
S
C
A
A
D
G
S
V
Site 29
S309
D
G
S
V
K
L
W
S
L
D
S
D
E
P
V
Site 30
S312
V
K
L
W
S
L
D
S
D
E
P
V
A
D
I
Site 31
T340
P
S
G
R
F
L
G
T
T
C
Y
D
R
S
W
Site 32
Y343
R
F
L
G
T
T
C
Y
D
R
S
W
R
L
W
Site 33
Y369
E
G
H
S
M
G
V
Y
D
I
A
F
H
Q
D
Site 34
Y411
E
G
H
L
K
E
I
Y
G
I
N
F
S
P
N
Site 35
Y420
I
N
F
S
P
N
G
Y
H
I
A
T
G
S
G
Site 36
S426
G
Y
H
I
A
T
G
S
G
D
N
T
C
K
V
Site 37
T430
A
T
G
S
G
D
N
T
C
K
V
W
D
L
R
Site 38
Y443
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Site 39
T444
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
L
Site 40
S483
I
W
T
H
P
G
W
S
P
L
K
T
L
A
G
Site 41
T487
P
G
W
S
P
L
K
T
L
A
G
H
E
G
K
Site 42
S501
K
V
M
G
L
D
I
S
S
D
G
Q
L
I
A
Site 43
T509
S
D
G
Q
L
I
A
T
C
S
Y
D
R
T
F
Site 44
S511
G
Q
L
I
A
T
C
S
Y
D
R
T
F
K
L
Site 45
Y512
Q
L
I
A
T
C
S
Y
D
R
T
F
K
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation