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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Pyrin
Full Name:
Pyrin
Alias:
Marenostrin
Type:
Mass (Da):
86444
Number AA:
781
UniProt ID:
O15553
International Prot ID:
IPI00007367
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
K
T
P
S
D
H
L
L
S
T
L
Site 2
S11
T
P
S
D
H
L
L
S
T
L
E
E
L
V
P
Site 3
T12
P
S
D
H
L
L
S
T
L
E
E
L
V
P
Y
Site 4
Y19
T
L
E
E
L
V
P
Y
D
F
E
K
F
K
F
Site 5
S32
K
F
K
L
Q
N
T
S
V
Q
K
E
H
S
R
Site 6
S43
E
H
S
R
I
P
R
S
Q
I
Q
R
A
R
P
Site 7
S95
R
A
A
I
Q
E
Y
S
T
Q
E
N
G
T
D
Site 8
S104
Q
E
N
G
T
D
D
S
A
A
S
S
S
L
G
Site 9
S108
T
D
D
S
A
A
S
S
S
L
G
E
N
K
P
Site 10
S117
L
G
E
N
K
P
R
S
L
K
T
P
D
H
P
Site 11
T120
N
K
P
R
S
L
K
T
P
D
H
P
E
G
N
Site 12
Y135
E
G
N
G
P
R
P
Y
G
G
G
A
A
S
L
Site 13
S141
P
Y
G
G
G
A
A
S
L
R
C
S
Q
P
E
Site 14
S145
G
A
A
S
L
R
C
S
Q
P
E
A
G
R
G
Site 15
S154
P
E
A
G
R
G
L
S
R
K
P
L
S
K
R
Site 16
S159
G
L
S
R
K
P
L
S
K
R
R
E
K
A
S
Site 17
S166
S
K
R
R
E
K
A
S
E
G
L
D
A
Q
G
Site 18
T177
D
A
Q
G
K
P
R
T
R
S
P
A
L
P
G
Site 19
S179
Q
G
K
P
R
T
R
S
P
A
L
P
G
G
R
Site 20
S187
P
A
L
P
G
G
R
S
P
G
P
C
R
A
L
Site 21
S208
V
R
L
R
R
N
A
S
S
A
G
R
L
Q
G
Site 22
S209
R
L
R
R
N
A
S
S
A
G
R
L
Q
G
L
Site 23
Y232
E
C
R
P
F
E
V
Y
L
P
S
G
K
M
R
Site 24
S235
P
F
E
V
Y
L
P
S
G
K
M
R
P
R
S
Site 25
S242
S
G
K
M
R
P
R
S
L
E
V
T
I
S
T
Site 26
T246
R
P
R
S
L
E
V
T
I
S
T
G
E
K
A
Site 27
S248
R
S
L
E
V
T
I
S
T
G
E
K
A
P
A
Site 28
T262
A
N
P
E
I
L
L
T
L
E
E
K
T
A
A
Site 29
T267
L
L
T
L
E
E
K
T
A
A
N
L
D
S
A
Site 30
S273
K
T
A
A
N
L
D
S
A
T
E
P
R
A
R
Site 31
T282
T
E
P
R
A
R
P
T
P
D
G
G
A
S
A
Site 32
S301
G
P
G
N
P
E
H
S
V
T
G
R
P
P
D
Site 33
T303
G
N
P
E
H
S
V
T
G
R
P
P
D
T
A
Site 34
T309
V
T
G
R
P
P
D
T
A
A
S
P
R
C
H
Site 35
S312
R
P
P
D
T
A
A
S
P
R
C
H
A
Q
E
Site 36
T326
E
G
D
P
V
D
G
T
C
V
R
D
S
C
S
Site 37
S331
D
G
T
C
V
R
D
S
C
S
F
P
E
A
V
Site 38
S333
T
C
V
R
D
S
C
S
F
P
E
A
V
S
G
Site 39
S339
C
S
F
P
E
A
V
S
G
H
P
Q
A
S
G
Site 40
S345
V
S
G
H
P
Q
A
S
G
S
R
S
P
G
C
Site 41
S347
G
H
P
Q
A
S
G
S
R
S
P
G
C
P
R
Site 42
S349
P
Q
A
S
G
S
R
S
P
G
C
P
R
C
Q
Site 43
S358
G
C
P
R
C
Q
D
S
H
E
R
K
S
P
G
Site 44
S363
Q
D
S
H
E
R
K
S
P
G
S
L
S
P
Q
Site 45
S366
H
E
R
K
S
P
G
S
L
S
P
Q
P
L
P
Site 46
S368
R
K
S
P
G
S
L
S
P
Q
P
L
P
Q
C
Site 47
S399
E
P
I
C
L
I
C
S
L
S
Q
E
H
Q
G
Site 48
S436
H
L
K
K
L
R
K
S
G
E
E
Q
R
S
Y
Site 49
S442
K
S
G
E
E
Q
R
S
Y
G
E
E
K
A
V
Site 50
Y443
S
G
E
E
Q
R
S
Y
G
E
E
K
A
V
S
Site 51
S450
Y
G
E
E
K
A
V
S
F
L
K
Q
T
E
A
Site 52
Y471
R
K
L
E
Q
V
Y
Y
F
L
E
Q
Q
E
H
Site 53
Y498
V
G
Q
I
R
K
A
Y
D
T
R
V
S
Q
D
Site 54
T500
Q
I
R
K
A
Y
D
T
R
V
S
Q
D
I
A
Site 55
S503
K
A
Y
D
T
R
V
S
Q
D
I
A
L
L
D
Site 56
S523
L
E
A
K
E
C
Q
S
E
W
E
L
L
Q
D
Site 57
T540
D
I
L
H
R
A
K
T
V
P
V
P
E
K
W
Site 58
T549
P
V
P
E
K
W
T
T
P
Q
E
I
K
Q
K
Site 59
S564
I
Q
L
L
H
Q
K
S
E
F
V
E
K
S
T
Site 60
S570
K
S
E
F
V
E
K
S
T
K
Y
F
S
E
T
Site 61
Y573
F
V
E
K
S
T
K
Y
F
S
E
T
L
R
S
Site 62
S575
E
K
S
T
K
Y
F
S
E
T
L
R
S
E
M
Site 63
T577
S
T
K
Y
F
S
E
T
L
R
S
E
M
E
M
Site 64
S614
A
Y
P
N
L
I
F
S
D
D
L
K
S
V
R
Site 65
S619
I
F
S
D
D
L
K
S
V
R
L
G
N
K
W
Site 66
S650
L
G
S
P
S
F
L
S
G
R
R
Y
W
E
V
Site 67
Y654
S
F
L
S
G
R
R
Y
W
E
V
E
V
G
D
Site 68
T672
W
I
L
G
A
C
K
T
S
I
S
R
K
G
N
Site 69
S673
I
L
G
A
C
K
T
S
I
S
R
K
G
N
M
Site 70
T681
I
S
R
K
G
N
M
T
L
S
P
E
N
G
Y
Site 71
S683
R
K
G
N
M
T
L
S
P
E
N
G
Y
W
V
Site 72
Y699
I
M
M
K
E
N
E
Y
Q
A
S
S
V
P
P
Site 73
S702
K
E
N
E
Y
Q
A
S
S
V
P
P
T
R
L
Site 74
S703
E
N
E
Y
Q
A
S
S
V
P
P
T
R
L
L
Site 75
T707
Q
A
S
S
V
P
P
T
R
L
L
I
K
E
P
Site 76
S730
D
Y
R
V
G
S
I
S
F
Y
N
V
T
A
R
Site 77
Y732
R
V
G
S
I
S
F
Y
N
V
T
A
R
S
H
Site 78
T735
S
I
S
F
Y
N
V
T
A
R
S
H
I
Y
T
Site 79
Y741
V
T
A
R
S
H
I
Y
T
F
A
S
C
S
F
Site 80
T742
T
A
R
S
H
I
Y
T
F
A
S
C
S
F
S
Site 81
S757
G
P
L
Q
P
I
F
S
P
G
T
R
D
G
G
Site 82
T771
G
K
N
T
A
P
L
T
I
C
P
V
G
G
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation