KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Per1
Full Name:
Period circadian protein homolog 1
Alias:
Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; hPER; KIAA0482; PER; period 1; Period circadian protein 1; RIGUI
Type:
Transcription protein
Mass (Da):
136212
Number AA:
1290
UniProt ID:
O15534
International Prot ID:
IPI00440484
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007623
GO:0009649
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
D
P
R
P
G
E
S
F
C
P
G
G
V
P
Site 2
S27
F
C
P
G
G
V
P
S
P
G
P
P
Q
H
R
Site 3
T45
G
P
S
L
A
D
D
T
D
A
N
S
N
G
S
Site 4
S49
A
D
D
T
D
A
N
S
N
G
S
S
G
N
E
Site 5
S53
D
A
N
S
N
G
S
S
G
N
E
S
N
G
H
Site 6
S57
N
G
S
S
G
N
E
S
N
G
H
E
S
R
G
Site 7
S62
N
E
S
N
G
H
E
S
R
G
A
S
Q
R
S
Site 8
S66
G
H
E
S
R
G
A
S
Q
R
S
S
H
S
S
Site 9
S69
S
R
G
A
S
Q
R
S
S
H
S
S
S
S
G
Site 10
S70
R
G
A
S
Q
R
S
S
H
S
S
S
S
G
N
Site 11
S72
A
S
Q
R
S
S
H
S
S
S
S
G
N
G
K
Site 12
S73
S
Q
R
S
S
H
S
S
S
S
G
N
G
K
D
Site 13
S74
Q
R
S
S
H
S
S
S
S
G
N
G
K
D
S
Site 14
S75
R
S
S
H
S
S
S
S
G
N
G
K
D
S
A
Site 15
T86
K
D
S
A
L
L
E
T
T
E
S
S
K
S
T
Site 16
T87
D
S
A
L
L
E
T
T
E
S
S
K
S
T
N
Site 17
S89
A
L
L
E
T
T
E
S
S
K
S
T
N
S
Q
Site 18
S90
L
L
E
T
T
E
S
S
K
S
T
N
S
Q
S
Site 19
S92
E
T
T
E
S
S
K
S
T
N
S
Q
S
P
S
Site 20
T93
T
T
E
S
S
K
S
T
N
S
Q
S
P
S
P
Site 21
S95
E
S
S
K
S
T
N
S
Q
S
P
S
P
P
S
Site 22
S97
S
K
S
T
N
S
Q
S
P
S
P
P
S
S
S
Site 23
S99
S
T
N
S
Q
S
P
S
P
P
S
S
S
I
A
Site 24
S102
S
Q
S
P
S
P
P
S
S
S
I
A
Y
S
L
Site 25
S103
Q
S
P
S
P
P
S
S
S
I
A
Y
S
L
L
Site 26
S104
S
P
S
P
P
S
S
S
I
A
Y
S
L
L
S
Site 27
Y107
P
P
S
S
S
I
A
Y
S
L
L
S
A
S
S
Site 28
S108
P
S
S
S
I
A
Y
S
L
L
S
A
S
S
E
Site 29
S111
S
I
A
Y
S
L
L
S
A
S
S
E
Q
D
N
Site 30
S114
Y
S
L
L
S
A
S
S
E
Q
D
N
P
S
T
Site 31
S120
S
S
E
Q
D
N
P
S
T
S
G
C
S
S
E
Site 32
T121
S
E
Q
D
N
P
S
T
S
G
C
S
S
E
Q
Site 33
S122
E
Q
D
N
P
S
T
S
G
C
S
S
E
Q
S
Site 34
S125
N
P
S
T
S
G
C
S
S
E
Q
S
A
R
A
Site 35
S126
P
S
T
S
G
C
S
S
E
Q
S
A
R
A
R
Site 36
S129
S
G
C
S
S
E
Q
S
A
R
A
R
T
Q
K
Site 37
T134
E
Q
S
A
R
A
R
T
Q
K
E
L
M
T
A
Site 38
T140
R
T
Q
K
E
L
M
T
A
L
R
E
L
K
L
Site 39
S159
E
R
R
G
K
G
R
S
G
T
L
A
T
L
Q
Site 40
T161
R
G
K
G
R
S
G
T
L
A
T
L
Q
Y
A
Site 41
T164
G
R
S
G
T
L
A
T
L
Q
Y
A
L
A
C
Site 42
Y167
G
T
L
A
T
L
Q
Y
A
L
A
C
V
K
Q
Site 43
Y182
V
Q
A
N
Q
E
Y
Y
Q
Q
W
S
L
E
E
Site 44
S194
L
E
E
G
E
P
C
S
M
D
M
S
T
Y
T
Site 45
S198
E
P
C
S
M
D
M
S
T
Y
T
L
E
E
L
Site 46
T199
P
C
S
M
D
M
S
T
Y
T
L
E
E
L
E
Site 47
T201
S
M
D
M
S
T
Y
T
L
E
E
L
E
H
I
Site 48
S210
E
E
L
E
H
I
T
S
E
Y
T
L
Q
N
Q
Site 49
T219
Y
T
L
Q
N
Q
D
T
F
S
V
A
V
S
F
Site 50
T252
K
R
D
V
F
R
G
T
R
F
S
E
L
L
A
Site 51
S255
V
F
R
G
T
R
F
S
E
L
L
A
P
Q
D
Site 52
Y267
P
Q
D
V
G
V
F
Y
G
S
T
A
P
S
R
Site 53
S269
D
V
G
V
F
Y
G
S
T
A
P
S
R
L
P
Site 54
S273
F
Y
G
S
T
A
P
S
R
L
P
T
W
G
T
Site 55
T277
T
A
P
S
R
L
P
T
W
G
T
G
A
S
A
Site 56
T280
S
R
L
P
T
W
G
T
G
A
S
A
G
S
G
Site 57
S283
P
T
W
G
T
G
A
S
A
G
S
G
L
R
D
Site 58
T292
G
S
G
L
R
D
F
T
Q
E
K
S
V
F
C
Site 59
S296
R
D
F
T
Q
E
K
S
V
F
C
R
I
R
G
Site 60
Y313
D
R
D
P
G
P
R
Y
Q
P
F
R
L
T
P
Site 61
T319
R
Y
Q
P
F
R
L
T
P
Y
V
T
K
I
R
Site 62
Y321
Q
P
F
R
L
T
P
Y
V
T
K
I
R
V
S
Site 63
T323
F
R
L
T
P
Y
V
T
K
I
R
V
S
D
G
Site 64
S328
Y
V
T
K
I
R
V
S
D
G
A
P
A
Q
P
Site 65
S346
L
I
A
E
R
I
H
S
G
Y
E
A
P
R
I
Site 66
Y348
A
E
R
I
H
S
G
Y
E
A
P
R
I
P
P
Site 67
T361
P
P
D
K
R
I
F
T
T
R
H
T
P
S
C
Site 68
T365
R
I
F
T
T
R
H
T
P
S
C
L
F
Q
D
Site 69
S423
A
G
Q
P
F
D
H
S
P
I
R
F
C
A
R
Site 70
Y434
F
C
A
R
N
G
E
Y
V
T
M
D
T
S
W
Site 71
T436
A
R
N
G
E
Y
V
T
M
D
T
S
W
A
G
Site 72
T463
L
G
R
H
K
V
R
T
A
P
L
N
E
D
V
Site 73
T472
P
L
N
E
D
V
F
T
P
P
A
P
S
P
A
Site 74
S477
V
F
T
P
P
A
P
S
P
A
P
S
L
D
T
Site 75
S481
P
A
P
S
P
A
P
S
L
D
T
D
I
Q
E
Site 76
T484
S
P
A
P
S
L
D
T
D
I
Q
E
L
S
E
Site 77
S490
D
T
D
I
Q
E
L
S
E
Q
I
H
R
L
L
Site 78
S523
T
S
P
G
P
L
H
S
P
G
S
S
S
D
S
Site 79
S526
G
P
L
H
S
P
G
S
S
S
D
S
N
G
G
Site 80
S527
P
L
H
S
P
G
S
S
S
D
S
N
G
G
D
Site 81
S528
L
H
S
P
G
S
S
S
D
S
N
G
G
D
A
Site 82
S530
S
P
G
S
S
S
D
S
N
G
G
D
A
E
G
Site 83
T545
P
G
P
P
A
P
V
T
F
Q
Q
I
C
K
D
Site 84
S573
E
S
R
A
R
P
Q
S
R
P
R
L
P
A
T
Site 85
T580
S
R
P
R
L
P
A
T
G
T
F
K
A
K
A
Site 86
T582
P
R
L
P
A
T
G
T
F
K
A
K
A
L
P
Site 87
S592
A
K
A
L
P
C
Q
S
P
D
P
E
L
E
A
Site 88
S622
A
E
R
K
E
A
S
S
C
S
Y
Q
Q
I
N
Site 89
Y625
K
E
A
S
S
C
S
Y
Q
Q
I
N
C
L
D
Site 90
S633
Q
Q
I
N
C
L
D
S
I
L
R
Y
L
E
S
Site 91
S640
S
I
L
R
Y
L
E
S
C
N
L
P
S
T
T
Site 92
S645
L
E
S
C
N
L
P
S
T
T
K
R
K
C
A
Site 93
T646
E
S
C
N
L
P
S
T
T
K
R
K
C
A
S
Site 94
T647
S
C
N
L
P
S
T
T
K
R
K
C
A
S
S
Site 95
S653
T
T
K
R
K
C
A
S
S
S
S
Y
T
T
S
Site 96
S654
T
K
R
K
C
A
S
S
S
S
Y
T
T
S
S
Site 97
S655
K
R
K
C
A
S
S
S
S
Y
T
T
S
S
A
Site 98
S656
R
K
C
A
S
S
S
S
Y
T
T
S
S
A
S
Site 99
Y657
K
C
A
S
S
S
S
Y
T
T
S
S
A
S
D
Site 100
T658
C
A
S
S
S
S
Y
T
T
S
S
A
S
D
D
Site 101
T659
A
S
S
S
S
Y
T
T
S
S
A
S
D
D
D
Site 102
S660
S
S
S
S
Y
T
T
S
S
A
S
D
D
D
R
Site 103
S661
S
S
S
Y
T
T
S
S
A
S
D
D
D
R
Q
Site 104
S663
S
Y
T
T
S
S
A
S
D
D
D
R
Q
R
T
Site 105
T670
S
D
D
D
R
Q
R
T
G
P
V
S
V
G
T
Site 106
S674
R
Q
R
T
G
P
V
S
V
G
T
K
K
D
P
Site 107
T677
T
G
P
V
S
V
G
T
K
K
D
P
P
S
A
Site 108
S683
G
T
K
K
D
P
P
S
A
A
L
S
G
E
G
Site 109
S687
D
P
P
S
A
A
L
S
G
E
G
A
T
P
R
Site 110
T692
A
L
S
G
E
G
A
T
P
R
K
E
P
V
V
Site 111
T702
K
E
P
V
V
G
G
T
L
S
P
L
A
L
A
Site 112
S704
P
V
V
G
G
T
L
S
P
L
A
L
A
N
K
Site 113
S714
A
L
A
N
K
A
E
S
V
V
S
V
T
S
Q
Site 114
S717
N
K
A
E
S
V
V
S
V
T
S
Q
C
S
F
Site 115
S720
E
S
V
V
S
V
T
S
Q
C
S
F
S
S
T
Site 116
T727
S
Q
C
S
F
S
S
T
I
V
H
V
G
D
K
Site 117
S739
G
D
K
K
P
P
E
S
D
I
I
M
M
E
D
Site 118
S757
L
A
P
G
P
A
P
S
P
A
P
S
P
T
V
Site 119
S761
P
A
P
S
P
A
P
S
P
T
V
A
P
D
P
Site 120
T763
P
S
P
A
P
S
P
T
V
A
P
D
P
A
P
Site 121
Y773
P
D
P
A
P
D
A
Y
R
P
V
G
L
T
K
Site 122
S809
G
R
L
R
G
L
D
S
S
S
T
A
P
S
A
Site 123
S810
R
L
R
G
L
D
S
S
S
T
A
P
S
A
L
Site 124
S811
L
R
G
L
D
S
S
S
T
A
P
S
A
L
G
Site 125
T812
R
G
L
D
S
S
S
T
A
P
S
A
L
G
E
Site 126
S815
D
S
S
S
T
A
P
S
A
L
G
E
R
G
C
Site 127
S830
H
H
G
P
A
P
P
S
R
R
H
H
C
R
S
Site 128
S837
S
R
R
H
H
C
R
S
K
A
K
R
S
R
H
Site 129
S842
C
R
S
K
A
K
R
S
R
H
H
Q
N
P
R
Site 130
Y855
P
R
A
E
A
P
C
Y
V
S
H
P
S
P
V
Site 131
S857
A
E
A
P
C
Y
V
S
H
P
S
P
V
P
P
Site 132
S860
P
C
Y
V
S
H
P
S
P
V
P
P
S
T
P
Site 133
S865
H
P
S
P
V
P
P
S
T
P
W
P
T
P
P
Site 134
T866
P
S
P
V
P
P
S
T
P
W
P
T
P
P
A
Site 135
T870
P
P
S
T
P
W
P
T
P
P
A
T
T
P
F
Site 136
T875
W
P
T
P
P
A
T
T
P
F
P
A
V
V
Q
Site 137
S890
P
Y
P
L
P
V
F
S
P
R
G
G
P
Q
P
Site 138
T930
L
P
N
Y
L
F
P
T
P
S
S
Y
P
Y
G
Site 139
S932
N
Y
L
F
P
T
P
S
S
Y
P
Y
G
A
L
Site 140
S933
Y
L
F
P
T
P
S
S
Y
P
Y
G
A
L
Q
Site 141
Y934
L
F
P
T
P
S
S
Y
P
Y
G
A
L
Q
T
Site 142
Y936
P
T
P
S
S
Y
P
Y
G
A
L
Q
T
P
A
Site 143
T941
Y
P
Y
G
A
L
Q
T
P
A
E
G
P
P
T
Site 144
T948
T
P
A
E
G
P
P
T
P
A
S
H
S
P
S
Site 145
S951
E
G
P
P
T
P
A
S
H
S
P
S
P
S
L
Site 146
S953
P
P
T
P
A
S
H
S
P
S
P
S
L
P
A
Site 147
S955
T
P
A
S
H
S
P
S
P
S
L
P
A
L
A
Site 148
S957
A
S
H
S
P
S
P
S
L
P
A
L
A
P
S
Site 149
S964
S
L
P
A
L
A
P
S
P
P
H
R
P
D
S
Site 150
S971
S
P
P
H
R
P
D
S
P
L
F
N
S
R
C
Site 151
S976
P
D
S
P
L
F
N
S
R
C
S
S
P
L
Q
Site 152
S979
P
L
F
N
S
R
C
S
S
P
L
Q
L
N
L
Site 153
S980
L
F
N
S
R
C
S
S
P
L
Q
L
N
L
L
Site 154
S1006
A
V
A
G
G
P
G
S
S
A
G
P
P
P
P
Site 155
S1007
V
A
G
G
P
G
S
S
A
G
P
P
P
P
S
Site 156
S1014
S
A
G
P
P
P
P
S
A
E
A
A
E
P
E
Site 157
T1028
E
A
R
L
A
E
V
T
E
S
S
N
Q
D
A
Site 158
S1030
R
L
A
E
V
T
E
S
S
N
Q
D
A
L
S
Site 159
S1031
L
A
E
V
T
E
S
S
N
Q
D
A
L
S
G
Site 160
S1037
S
S
N
Q
D
A
L
S
G
S
S
D
L
L
E
Site 161
S1051
E
L
L
L
Q
E
D
S
R
S
G
T
G
S
A
Site 162
S1053
L
L
Q
E
D
S
R
S
G
T
G
S
A
A
S
Site 163
T1055
Q
E
D
S
R
S
G
T
G
S
A
A
S
G
S
Site 164
S1057
D
S
R
S
G
T
G
S
A
A
S
G
S
L
G
Site 165
S1060
S
G
T
G
S
A
A
S
G
S
L
G
S
G
L
Site 166
S1062
T
G
S
A
A
S
G
S
L
G
S
G
L
G
S
Site 167
S1069
S
L
G
S
G
L
G
S
G
S
G
S
G
S
H
Site 168
S1071
G
S
G
L
G
S
G
S
G
S
G
S
H
E
G
Site 169
S1073
G
L
G
S
G
S
G
S
G
S
H
E
G
G
S
Site 170
S1075
G
S
G
S
G
S
G
S
H
E
G
G
S
T
S
Site 171
S1080
S
G
S
H
E
G
G
S
T
S
A
S
I
T
R
Site 172
T1081
G
S
H
E
G
G
S
T
S
A
S
I
T
R
S
Site 173
S1082
S
H
E
G
G
S
T
S
A
S
I
T
R
S
S
Site 174
S1084
E
G
G
S
T
S
A
S
I
T
R
S
S
Q
S
Site 175
T1086
G
S
T
S
A
S
I
T
R
S
S
Q
S
S
H
Site 176
S1088
T
S
A
S
I
T
R
S
S
Q
S
S
H
T
S
Site 177
S1089
S
A
S
I
T
R
S
S
Q
S
S
H
T
S
K
Site 178
S1091
S
I
T
R
S
S
Q
S
S
H
T
S
K
Y
F
Site 179
S1092
I
T
R
S
S
Q
S
S
H
T
S
K
Y
F
G
Site 180
S1095
S
S
Q
S
S
H
T
S
K
Y
F
G
S
I
D
Site 181
Y1097
Q
S
S
H
T
S
K
Y
F
G
S
I
D
S
S
Site 182
S1100
H
T
S
K
Y
F
G
S
I
D
S
S
E
A
E
Site 183
S1103
K
Y
F
G
S
I
D
S
S
E
A
E
A
G
A
Site 184
S1104
Y
F
G
S
I
D
S
S
E
A
E
A
G
A
A
Site 185
Y1124
P
G
D
Q
V
I
K
Y
V
L
Q
D
P
I
W
Site 186
Y1145
D
Q
R
V
M
M
T
Y
Q
V
P
S
R
D
M
Site 187
T1153
Q
V
P
S
R
D
M
T
S
V
L
K
Q
D
R
Site 188
S1174
Q
K
Q
Q
P
R
F
S
E
D
Q
R
R
E
L
Site 189
S1186
R
E
L
G
A
V
H
S
W
V
R
K
G
Q
L
Site 190
T1209
C
V
D
C
G
S
S
T
Q
D
P
G
H
P
D
Site 191
S1221
H
P
D
D
P
L
F
S
E
L
D
G
L
G
L
Site 192
S1240
E
G
G
G
E
Q
G
S
S
G
G
G
S
G
E
Site 193
S1241
G
G
G
E
Q
G
S
S
G
G
G
S
G
E
G
Site 194
S1245
Q
G
S
S
G
G
G
S
G
E
G
E
G
C
E
Site 195
S1261
A
Q
G
G
A
K
A
S
S
S
Q
D
L
A
M
Site 196
S1262
Q
G
G
A
K
A
S
S
S
Q
D
L
A
M
E
Site 197
S1263
G
G
A
K
A
S
S
S
Q
D
L
A
M
E
E
Site 198
S1276
E
E
E
E
E
G
R
S
S
S
S
P
A
L
P
Site 199
S1277
E
E
E
E
G
R
S
S
S
S
P
A
L
P
T
Site 200
S1278
E
E
E
G
R
S
S
S
S
P
A
L
P
T
A
Site 201
S1279
E
E
G
R
S
S
S
S
P
A
L
P
T
A
G
Site 202
T1284
S
S
S
P
A
L
P
T
A
G
N
C
T
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation