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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN5
Full Name:
Calpain-5
Alias:
Calpain htra-3;New calpain 3
Type:
Mass (Da):
73169
Number AA:
640
UniProt ID:
O15484
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
K
P
Y
E
D
Q
N
Y
S
A
L
R
R
D
C
Site 2
T35
E
D
P
L
F
P
A
T
D
D
S
L
Y
Y
K
Site 3
S38
L
F
P
A
T
D
D
S
L
Y
Y
K
G
T
P
Site 4
Y40
P
A
T
D
D
S
L
Y
Y
K
G
T
P
G
P
Site 5
Y41
A
T
D
D
S
L
Y
Y
K
G
T
P
G
P
A
Site 6
T44
D
S
L
Y
Y
K
G
T
P
G
P
A
V
R
W
Site 7
S69
R
L
F
V
D
G
I
S
S
H
D
L
H
Q
G
Site 8
S92
A
A
C
S
S
L
A
S
R
E
S
L
W
Q
K
Site 9
S95
S
S
L
A
S
R
E
S
L
W
Q
K
V
I
P
Site 10
T142
V
I
D
D
R
L
P
T
V
N
N
Q
L
I
Y
Site 11
Y149
T
V
N
N
Q
L
I
Y
C
H
S
N
S
R
N
Site 12
T200
V
S
E
P
I
D
L
T
E
G
D
F
A
N
D
Site 13
T209
G
D
F
A
N
D
E
T
K
R
N
Q
L
F
E
Site 14
S299
N
G
P
W
S
D
T
S
E
E
W
Q
K
V
S
Site 15
S306
S
E
E
W
Q
K
V
S
K
S
E
R
E
K
M
Site 16
S308
E
W
Q
K
V
S
K
S
E
R
E
K
M
G
V
Site 17
T316
E
R
E
K
M
G
V
T
V
Q
D
D
G
E
F
Site 18
T345
I
K
C
R
V
I
N
T
S
H
L
S
I
H
K
Site 19
S346
K
C
R
V
I
N
T
S
H
L
S
I
H
K
T
Site 20
T353
S
H
L
S
I
H
K
T
W
E
E
A
R
L
H
Site 21
T364
A
R
L
H
G
A
W
T
L
H
E
D
P
R
Q
Site 22
Y390
T
F
F
Q
N
P
Q
Y
I
F
E
V
K
K
P
Site 23
S412
I
Q
Q
R
P
K
R
S
T
R
R
E
G
K
G
Site 24
T413
Q
Q
R
P
K
R
S
T
R
R
E
G
K
G
E
Site 25
Y429
L
A
I
G
F
D
I
Y
K
V
E
E
N
R
Q
Site 26
Y437
K
V
E
E
N
R
Q
Y
R
M
H
S
L
Q
H
Site 27
S441
N
R
Q
Y
R
M
H
S
L
Q
H
K
A
A
S
Site 28
S449
L
Q
H
K
A
A
S
S
I
Y
I
N
S
R
S
Site 29
S456
S
I
Y
I
N
S
R
S
V
F
L
R
T
D
Q
Site 30
T461
S
R
S
V
F
L
R
T
D
Q
P
E
G
R
Y
Site 31
Y468
T
D
Q
P
E
G
R
Y
V
I
I
P
T
T
F
Site 32
T474
R
Y
V
I
I
P
T
T
F
E
P
G
H
T
G
Site 33
T480
T
T
F
E
P
G
H
T
G
E
F
L
L
R
V
Site 34
S493
R
V
F
T
D
V
P
S
N
C
R
E
L
R
L
Site 35
T506
R
L
D
E
P
P
H
T
C
W
S
S
L
C
G
Site 36
S532
G
A
A
G
L
K
D
S
P
T
G
A
N
S
Y
Site 37
T534
A
G
L
K
D
S
P
T
G
A
N
S
Y
V
I
Site 38
Y539
S
P
T
G
A
N
S
Y
V
I
I
K
C
E
G
Site 39
T559
A
V
Q
K
G
T
S
T
P
E
Y
N
V
K
G
Site 40
Y562
K
G
T
S
T
P
E
Y
N
V
K
G
I
F
Y
Site 41
S574
I
F
Y
R
K
K
L
S
Q
P
I
T
V
Q
V
Site 42
T578
K
K
L
S
Q
P
I
T
V
Q
V
W
N
H
R
Site 43
S617
L
H
L
R
D
R
N
S
R
Q
P
S
N
L
P
Site 44
S621
D
R
N
S
R
Q
P
S
N
L
P
G
T
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation