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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC5
Full Name:
Multidrug resistance-associated protein 5
Alias:
ABC33; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP) member 5; Canalicular multispecific organic anion transporter C; EST277145; MOATC; MOAT-C; MRP5; Multidrug resistance-associated 5; Multi-specific organic anion transporter-C; PABC11; SMRP
Type:
Transporter protein; Membrane fraction, membrane, integral plasma membrane protein
Mass (Da):
160660
Number AA:
1437
UniProt ID:
O15440
International Prot ID:
IPI00385383
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
GO:0008514
PhosphoSite+
KinaseNET
Biological Process:
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
D
I
D
I
G
K
E
Y
I
I
P
S
P
G
Y
Site 2
S14
G
K
E
Y
I
I
P
S
P
G
Y
R
S
V
R
Site 3
Y17
Y
I
I
P
S
P
G
Y
R
S
V
R
E
R
T
Site 4
S19
I
P
S
P
G
Y
R
S
V
R
E
R
T
S
T
Site 5
T24
Y
R
S
V
R
E
R
T
S
T
S
G
T
H
R
Site 6
S25
R
S
V
R
E
R
T
S
T
S
G
T
H
R
D
Site 7
T26
S
V
R
E
R
T
S
T
S
G
T
H
R
D
R
Site 8
T29
E
R
T
S
T
S
G
T
H
R
D
R
E
D
S
Site 9
S36
T
H
R
D
R
E
D
S
K
F
R
R
T
R
P
Site 10
T41
E
D
S
K
F
R
R
T
R
P
L
E
C
Q
D
Site 11
S60
A
A
R
A
E
G
L
S
L
D
A
S
M
H
S
Site 12
S64
E
G
L
S
L
D
A
S
M
H
S
Q
L
R
I
Site 13
S67
S
L
D
A
S
M
H
S
Q
L
R
I
L
D
E
Site 14
Y81
E
E
H
P
K
G
K
Y
H
H
G
L
S
A
L
Site 15
S86
G
K
Y
H
H
G
L
S
A
L
K
P
I
R
T
Site 16
T93
S
A
L
K
P
I
R
T
T
S
K
H
Q
H
P
Site 17
T94
A
L
K
P
I
R
T
T
S
K
H
Q
H
P
V
Site 18
S95
L
K
P
I
R
T
T
S
K
H
Q
H
P
V
D
Site 19
S129
A
H
K
K
G
E
L
S
M
E
D
V
W
S
L
Site 20
S135
L
S
M
E
D
V
W
S
L
S
K
H
E
S
S
Site 21
S137
M
E
D
V
W
S
L
S
K
H
E
S
S
D
V
Site 22
S141
W
S
L
S
K
H
E
S
S
D
V
N
C
R
R
Site 23
S142
S
L
S
K
H
E
S
S
D
V
N
C
R
R
L
Site 24
S213
E
Y
T
Q
A
T
E
S
N
L
Q
Y
S
L
L
Site 25
T239
R
S
W
S
L
A
L
T
W
A
L
N
Y
R
T
Site 26
S272
L
K
N
I
K
E
K
S
L
G
E
L
I
N
I
Site 27
T340
M
M
F
A
S
R
L
T
A
Y
F
R
R
K
C
Site 28
Y342
F
A
S
R
L
T
A
Y
F
R
R
K
C
V
A
Site 29
Y364
K
M
N
E
V
L
T
Y
I
K
F
I
K
M
Y
Site 30
S378
Y
A
W
V
K
A
F
S
Q
S
V
Q
K
I
R
Site 31
S485
M
I
K
N
K
P
A
S
P
H
I
K
I
E
M
Site 32
T496
K
I
E
M
K
N
A
T
L
A
W
D
S
S
H
Site 33
S501
N
A
T
L
A
W
D
S
S
H
S
S
I
Q
N
Site 34
S502
A
T
L
A
W
D
S
S
H
S
S
I
Q
N
S
Site 35
S504
L
A
W
D
S
S
H
S
S
I
Q
N
S
P
K
Site 36
S505
A
W
D
S
S
H
S
S
I
Q
N
S
P
K
L
Site 37
S509
S
H
S
S
I
Q
N
S
P
K
L
T
P
K
M
Site 38
T513
I
Q
N
S
P
K
L
T
P
K
M
K
K
D
K
Site 39
S523
M
K
K
D
K
R
A
S
R
G
K
K
E
K
V
Site 40
T536
K
V
R
Q
L
Q
R
T
E
H
Q
A
V
L
A
Site 41
S553
K
G
H
L
L
L
D
S
D
E
R
P
S
P
E
Site 42
S558
L
D
S
D
E
R
P
S
P
E
E
E
E
G
K
Site 43
T577
G
H
L
R
L
Q
R
T
L
H
S
I
D
L
E
Site 44
Y649
N
I
L
F
G
K
E
Y
D
E
E
R
Y
N
S
Site 45
Y654
K
E
Y
D
E
E
R
Y
N
S
V
L
N
S
C
Site 46
S656
Y
D
E
E
R
Y
N
S
V
L
N
S
C
C
L
Site 47
S660
R
Y
N
S
V
L
N
S
C
C
L
R
P
D
L
Site 48
T676
I
L
P
S
S
D
L
T
E
I
G
E
R
G
A
Site 49
S686
G
E
R
G
A
N
L
S
G
G
Q
R
Q
R
I
Site 50
S694
G
G
Q
R
Q
R
I
S
L
A
R
A
L
Y
S
Site 51
S704
R
A
L
Y
S
D
R
S
I
Y
I
L
D
D
P
Site 52
Y706
L
Y
S
D
R
S
I
Y
I
L
D
D
P
L
S
Site 53
T736
R
K
H
L
K
S
K
T
V
L
F
V
T
H
Q
Site 54
T762
F
M
K
E
G
C
I
T
E
R
G
T
H
E
E
Site 55
T766
G
C
I
T
E
R
G
T
H
E
E
L
M
N
L
Site 56
T789
N
N
L
L
L
G
E
T
P
P
V
E
I
N
S
Site 57
T800
E
I
N
S
K
K
E
T
S
G
S
Q
K
K
S
Site 58
S801
I
N
S
K
K
E
T
S
G
S
Q
K
K
S
Q
Site 59
S803
S
K
K
E
T
S
G
S
Q
K
K
S
Q
D
K
Site 60
S807
T
S
G
S
Q
K
K
S
Q
D
K
G
P
K
T
Site 61
T814
S
Q
D
K
G
P
K
T
G
S
V
K
K
E
K
Site 62
S816
D
K
G
P
K
T
G
S
V
K
K
E
K
A
V
Site 63
S840
L
E
E
K
G
Q
G
S
V
P
W
S
V
Y
G
Site 64
T892
K
Q
G
S
G
N
T
T
V
T
R
G
N
E
T
Site 65
S900
V
T
R
G
N
E
T
S
V
S
D
S
M
K
D
Site 66
S902
R
G
N
E
T
S
V
S
D
S
M
K
D
N
P
Site 67
S904
N
E
T
S
V
S
D
S
M
K
D
N
P
H
M
Site 68
Y913
K
D
N
P
H
M
Q
Y
Y
A
S
I
Y
A
L
Site 69
Y914
D
N
P
H
M
Q
Y
Y
A
S
I
Y
A
L
S
Site 70
S944
V
K
G
T
L
R
A
S
S
R
L
H
D
E
L
Site 71
S945
K
G
T
L
R
A
S
S
R
L
H
D
E
L
F
Site 72
S958
L
F
R
R
I
L
R
S
P
M
K
F
F
D
T
Site 73
T965
S
P
M
K
F
F
D
T
T
P
T
G
R
I
L
Site 74
T966
P
M
K
F
F
D
T
T
P
T
G
R
I
L
N
Site 75
T968
K
F
F
D
T
T
P
T
G
R
I
L
N
R
F
Site 76
S976
G
R
I
L
N
R
F
S
K
D
M
D
E
V
D
Site 77
T1046
L
K
R
L
D
N
I
T
Q
S
P
F
L
S
H
Site 78
S1048
R
L
D
N
I
T
Q
S
P
F
L
S
H
I
T
Site 79
S1052
I
T
Q
S
P
F
L
S
H
I
T
S
S
I
Q
Site 80
Y1077
G
Q
E
F
L
H
R
Y
Q
E
L
L
D
D
N
Site 81
S1151
Q
F
T
V
R
L
A
S
E
T
E
A
R
F
T
Site 82
T1153
T
V
R
L
A
S
E
T
E
A
R
F
T
S
V
Site 83
T1158
S
E
T
E
A
R
F
T
S
V
E
R
I
N
H
Site 84
S1159
E
T
E
A
R
F
T
S
V
E
R
I
N
H
Y
Site 85
Y1166
S
V
E
R
I
N
H
Y
I
K
T
L
S
L
E
Site 86
T1169
R
I
N
H
Y
I
K
T
L
S
L
E
A
P
A
Site 87
S1171
N
H
Y
I
K
T
L
S
L
E
A
P
A
R
I
Site 88
S1184
R
I
K
N
K
A
P
S
P
D
W
P
Q
E
G
Site 89
T1194
W
P
Q
E
G
E
V
T
F
E
N
A
E
M
R
Site 90
Y1202
F
E
N
A
E
M
R
Y
R
E
N
L
P
L
V
Site 91
S1214
P
L
V
L
K
K
V
S
F
T
I
K
P
K
E
Site 92
T1216
V
L
K
K
V
S
F
T
I
K
P
K
E
K
I
Site 93
T1229
K
I
G
I
V
G
R
T
G
S
G
K
S
S
L
Site 94
S1231
G
I
V
G
R
T
G
S
G
K
S
S
L
G
M
Site 95
S1234
G
R
T
G
S
G
K
S
S
L
G
M
A
L
F
Site 96
S1235
R
T
G
S
G
K
S
S
L
G
M
A
L
F
R
Site 97
S1268
I
G
L
A
D
L
R
S
K
L
S
I
I
P
Q
Site 98
S1271
A
D
L
R
S
K
L
S
I
I
P
Q
E
P
V
Site 99
S1281
P
Q
E
P
V
L
F
S
G
T
V
R
S
N
L
Site 100
T1283
E
P
V
L
F
S
G
T
V
R
S
N
L
D
P
Site 101
S1286
L
F
S
G
T
V
R
S
N
L
D
P
F
N
Q
Site 102
Y1294
N
L
D
P
F
N
Q
Y
T
E
D
Q
I
W
D
Site 103
S1331
M
E
N
G
D
N
F
S
V
G
E
R
Q
L
L
Site 104
T1362
E
A
T
A
A
M
D
T
E
T
D
L
L
I
Q
Site 105
T1371
T
D
L
L
I
Q
E
T
I
R
E
A
F
A
D
Site 106
T1390
T
I
A
H
R
L
H
T
V
L
G
S
D
R
I
Site 107
S1416
D
T
P
S
V
L
L
S
N
D
S
S
R
F
Y
Site 108
Y1423
S
N
D
S
S
R
F
Y
A
M
F
A
A
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation