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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC4
Full Name:
Multidrug resistance-associated protein 4
Alias:
ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP) member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; BA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); Canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOATB; MOAT-B; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion tranporter-B; Multispecific organic anion transporter B
Type:
Transporter
Mass (Da):
149527
Number AA:
1325
UniProt ID:
O15439
International Prot ID:
IPI00006675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0016404
GO:0005524
GO:0042626
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y45
R
L
E
E
D
D
M
Y
S
V
L
P
E
D
R
Site 2
S46
L
E
E
D
D
M
Y
S
V
L
P
E
D
R
S
Site 3
S53
S
V
L
P
E
D
R
S
Q
H
L
G
E
E
L
Site 4
S79
E
N
D
A
Q
K
P
S
L
T
R
A
I
I
K
Site 5
Y119
F
L
G
K
I
I
N
Y
F
E
N
Y
D
P
M
Site 6
S128
E
N
Y
D
P
M
D
S
V
A
L
N
T
A
Y
Site 7
S182
Y
R
K
A
L
R
L
S
N
M
A
M
G
K
T
Site 8
S199
G
Q
I
V
N
L
L
S
N
D
V
N
K
F
D
Site 9
S259
S
C
F
G
K
L
F
S
S
L
R
S
K
T
A
Site 10
S260
C
F
G
K
L
F
S
S
L
R
S
K
T
A
T
Site 11
S263
K
L
F
S
S
L
R
S
K
T
A
T
F
T
D
Site 12
T265
F
S
S
L
R
S
K
T
A
T
F
T
D
A
R
Site 13
T267
S
L
R
S
K
T
A
T
F
T
D
A
R
I
R
Site 14
T269
R
S
K
T
A
T
F
T
D
A
R
I
R
T
M
Site 15
T275
F
T
D
A
R
I
R
T
M
N
E
V
I
T
G
Site 16
Y289
G
I
R
I
I
K
M
Y
A
W
E
K
S
F
S
Site 17
T300
K
S
F
S
N
L
I
T
N
L
R
K
K
E
I
Site 18
S308
N
L
R
K
K
E
I
S
K
I
L
R
S
S
C
Site 19
S313
E
I
S
K
I
L
R
S
S
C
L
R
G
M
N
Site 20
S314
I
S
K
I
L
R
S
S
C
L
R
G
M
N
L
Site 21
S396
F
L
L
L
D
E
I
S
Q
R
N
R
Q
L
P
Site 22
S404
Q
R
N
R
Q
L
P
S
D
G
K
K
M
V
H
Site 23
S423
T
A
F
W
D
K
A
S
E
T
P
T
L
Q
G
Site 24
T425
F
W
D
K
A
S
E
T
P
T
L
Q
G
L
S
Site 25
T427
D
K
A
S
E
T
P
T
L
Q
G
L
S
F
T
Site 26
S432
T
P
T
L
Q
G
L
S
F
T
V
R
P
G
E
Site 27
Y477
S
V
H
G
R
I
A
Y
V
S
Q
Q
P
W
V
Site 28
Y499
N
I
L
F
G
K
K
Y
E
K
E
R
Y
E
K
Site 29
Y504
K
K
Y
E
K
E
R
Y
E
K
V
I
K
A
C
Site 30
T526
L
L
E
D
G
D
L
T
V
I
G
D
R
G
T
Site 31
T533
T
V
I
G
D
R
G
T
T
L
S
G
G
Q
K
Site 32
T534
V
I
G
D
R
G
T
T
L
S
G
G
Q
K
A
Site 33
S536
G
D
R
G
T
T
L
S
G
G
Q
K
A
R
V
Site 34
Y556
V
Y
Q
D
A
D
I
Y
L
L
D
D
P
L
S
Site 35
S601
L
Q
Y
L
K
A
A
S
Q
I
L
I
L
K
D
Site 36
Y617
K
M
V
Q
K
G
T
Y
T
E
F
L
K
S
G
Site 37
S623
T
Y
T
E
F
L
K
S
G
I
D
F
G
S
L
Site 38
S629
K
S
G
I
D
F
G
S
L
L
K
K
D
N
E
Site 39
T646
E
Q
P
P
V
P
G
T
P
T
L
R
N
R
T
Site 40
T648
P
P
V
P
G
T
P
T
L
R
N
R
T
F
S
Site 41
T653
T
P
T
L
R
N
R
T
F
S
E
S
S
V
W
Site 42
S655
T
L
R
N
R
T
F
S
E
S
S
V
W
S
Q
Site 43
S657
R
N
R
T
F
S
E
S
S
V
W
S
Q
Q
S
Site 44
S658
N
R
T
F
S
E
S
S
V
W
S
Q
Q
S
S
Site 45
S661
F
S
E
S
S
V
W
S
Q
Q
S
S
R
P
S
Site 46
S664
S
S
V
W
S
Q
Q
S
S
R
P
S
L
K
D
Site 47
S665
S
V
W
S
Q
Q
S
S
R
P
S
L
K
D
G
Site 48
S668
S
Q
Q
S
S
R
P
S
L
K
D
G
A
L
E
Site 49
S676
L
K
D
G
A
L
E
S
Q
D
T
E
N
V
P
Site 50
T679
G
A
L
E
S
Q
D
T
E
N
V
P
V
T
L
Site 51
T685
D
T
E
N
V
P
V
T
L
S
E
E
N
R
S
Site 52
S687
E
N
V
P
V
T
L
S
E
E
N
R
S
E
G
Site 53
S692
T
L
S
E
E
N
R
S
E
G
K
V
G
F
Q
Site 54
Y701
G
K
V
G
F
Q
A
Y
K
N
Y
F
R
A
G
Site 55
Y704
G
F
Q
A
Y
K
N
Y
F
R
A
G
A
H
W
Site 56
T748
K
Q
S
M
L
N
V
T
V
N
G
G
G
N
V
Site 57
Y764
E
K
L
D
L
N
W
Y
L
G
I
Y
S
G
L
Site 58
S826
G
R
I
L
N
R
F
S
K
D
I
G
H
L
D
Site 59
T885
L
R
R
Y
F
L
E
T
S
R
D
V
K
R
L
Site 60
S894
R
D
V
K
R
L
E
S
T
T
R
S
P
V
F
Site 61
T896
V
K
R
L
E
S
T
T
R
S
P
V
F
S
H
Site 62
S898
R
L
E
S
T
T
R
S
P
V
F
S
H
L
S
Site 63
S902
T
T
R
S
P
V
F
S
H
L
S
S
S
L
Q
Site 64
T913
S
S
L
Q
G
L
W
T
I
R
A
Y
K
A
E
Site 65
Y917
G
L
W
T
I
R
A
Y
K
A
E
E
R
C
Q
Site 66
T1017
V
E
R
V
I
E
Y
T
D
L
E
K
E
A
P
Site 67
Y1027
E
K
E
A
P
W
E
Y
Q
K
R
P
P
P
A
Site 68
S1083
R
T
G
A
G
K
S
S
L
I
S
A
L
F
R
Site 69
S1092
I
S
A
L
F
R
L
S
E
P
E
G
K
I
W
Site 70
S1118
H
D
L
R
K
K
M
S
I
I
P
Q
E
P
V
Site 71
T1168
D
L
P
G
K
M
D
T
E
L
A
E
S
G
S
Site 72
S1173
M
D
T
E
L
A
E
S
G
S
N
F
S
V
G
Site 73
S1175
T
E
L
A
E
S
G
S
N
F
S
V
G
Q
R
Site 74
T1211
T
A
N
V
D
P
R
T
D
E
L
I
Q
K
K
Site 75
T1227
R
E
K
F
A
H
C
T
V
L
T
I
A
H
R
Site 76
T1237
T
I
A
H
R
L
N
T
I
I
D
S
D
K
I
Site 77
S1249
D
K
I
M
V
L
D
S
G
R
L
K
E
Y
D
Site 78
Y1255
D
S
G
R
L
K
E
Y
D
E
P
Y
V
L
L
Site 79
Y1259
L
K
E
Y
D
E
P
Y
V
L
L
Q
N
K
E
Site 80
S1267
V
L
L
Q
N
K
E
S
L
F
Y
K
M
V
Q
Site 81
Y1270
Q
N
K
E
S
L
F
Y
K
M
V
Q
Q
L
G
Site 82
Y1292
T
E
T
A
K
Q
V
Y
F
K
R
N
Y
P
H
Site 83
Y1297
Q
V
Y
F
K
R
N
Y
P
H
I
G
H
T
D
Site 84
T1317
T
S
N
G
Q
P
S
T
L
T
I
F
E
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation