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Updated November 2019
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Protein Info
Short Name:
TNRC18
Full Name:
Trinucleotide repeat-containing gene 18 protein
Alias:
CAGL79; Long CAG trinucleotide repeat-containing gene 79 protein; TNRC18A; Trinucleotide repeat containing 18
Type:
Unknown function
Mass (Da):
314519
Number AA:
2968
UniProt ID:
O15417
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
D
F
G
P
Q
R
S
V
H
G
P
P
P
P
Site 2
S21
G
P
P
P
P
L
L
S
G
L
A
M
D
S
H
Site 3
T34
S
H
R
V
G
A
A
T
A
G
R
L
P
A
S
Site 4
Y52
G
P
L
P
P
G
K
Y
M
A
G
L
N
L
H
Site 5
S78
V
A
S
G
M
G
P
S
A
S
S
H
G
S
P
Site 6
S80
S
G
M
G
P
S
A
S
S
H
G
S
P
V
P
Site 7
S81
G
M
G
P
S
A
S
S
H
G
S
P
V
P
L
Site 8
S84
P
S
A
S
S
H
G
S
P
V
P
L
P
S
D
Site 9
S90
G
S
P
V
P
L
P
S
D
L
S
F
R
S
P
Site 10
S93
V
P
L
P
S
D
L
S
F
R
S
P
T
P
S
Site 11
S96
P
S
D
L
S
F
R
S
P
T
P
S
N
L
P
Site 12
T98
D
L
S
F
R
S
P
T
P
S
N
L
P
M
V
Site 13
S100
S
F
R
S
P
T
P
S
N
L
P
M
V
Q
L
Site 14
S117
A
H
A
H
E
G
F
S
H
L
P
S
G
L
Y
Site 15
S121
E
G
F
S
H
L
P
S
G
L
Y
P
S
Y
L
Site 16
Y124
S
H
L
P
S
G
L
Y
P
S
Y
L
H
L
N
Site 17
S126
L
P
S
G
L
Y
P
S
Y
L
H
L
N
H
L
Site 18
Y127
P
S
G
L
Y
P
S
Y
L
H
L
N
H
L
E
Site 19
S137
L
N
H
L
E
P
P
S
S
G
S
P
L
L
S
Site 20
S138
N
H
L
E
P
P
S
S
G
S
P
L
L
S
Q
Site 21
S140
L
E
P
P
S
S
G
S
P
L
L
S
Q
L
G
Site 22
S144
S
S
G
S
P
L
L
S
Q
L
G
Q
P
S
I
Site 23
S150
L
S
Q
L
G
Q
P
S
I
F
D
T
Q
K
G
Site 24
T154
G
Q
P
S
I
F
D
T
Q
K
G
Q
G
P
G
Site 25
Y166
G
P
G
G
D
G
F
Y
L
P
T
A
G
A
P
Site 26
S175
P
T
A
G
A
P
G
S
L
H
S
H
A
P
S
Site 27
S178
G
A
P
G
S
L
H
S
H
A
P
S
A
R
T
Site 28
S182
S
L
H
S
H
A
P
S
A
R
T
P
G
G
G
Site 29
T185
S
H
A
P
S
A
R
T
P
G
G
G
H
S
S
Site 30
S192
T
P
G
G
G
H
S
S
G
A
P
A
K
G
S
Site 31
S199
S
G
A
P
A
K
G
S
S
S
R
D
G
P
A
Site 32
S200
G
A
P
A
K
G
S
S
S
R
D
G
P
A
K
Site 33
S233
R
A
R
G
E
E
A
S
G
P
R
G
V
V
D
Site 34
T242
P
R
G
V
V
D
L
T
Q
E
A
R
A
E
G
Site 35
S263
P
R
L
A
E
R
L
S
P
F
L
A
E
S
K
Site 36
S269
L
S
P
F
L
A
E
S
K
T
K
N
A
A
L
Site 37
T271
P
F
L
A
E
S
K
T
K
N
A
A
L
Q
P
Site 38
T321
G
A
R
L
L
R
R
T
E
T
L
L
P
G
P
Site 39
T323
R
L
L
R
R
T
E
T
L
L
P
G
P
R
P
Site 40
S333
P
G
P
R
P
C
P
S
P
L
P
P
P
P
A
Site 41
T358
A
T
P
A
G
V
Y
T
V
F
R
E
Q
G
R
Site 42
S392
P
G
P
I
Q
I
A
S
Q
A
R
D
A
R
A
Site 43
S416
V
L
Q
A
P
P
G
S
P
R
P
L
D
R
P
Site 44
S431
E
G
L
R
E
K
N
S
V
I
R
S
L
K
R
Site 45
S435
E
K
N
S
V
I
R
S
L
K
R
P
P
P
A
Site 46
T446
P
P
P
A
D
A
P
T
V
R
A
T
R
A
S
Site 47
T450
D
A
P
T
V
R
A
T
R
A
S
P
D
P
R
Site 48
S453
T
V
R
A
T
R
A
S
P
D
P
R
A
Y
V
Site 49
Y459
A
S
P
D
P
R
A
Y
V
P
A
K
E
L
L
Site 50
T504
E
P
G
R
P
P
P
T
G
P
E
H
K
W
K
Site 51
Y551
A
S
S
S
K
K
A
Y
L
D
P
G
A
V
L
Site 52
S561
P
G
A
V
L
P
R
S
A
A
T
C
G
R
P
Site 53
S574
R
P
V
A
D
M
H
S
A
A
H
G
S
G
E
Site 54
S579
M
H
S
A
A
H
G
S
G
E
A
S
A
M
Q
Site 55
S583
A
H
G
S
G
E
A
S
A
M
Q
S
L
I
K
Site 56
S587
G
E
A
S
A
M
Q
S
L
I
K
Y
S
G
S
Site 57
Y591
A
M
Q
S
L
I
K
Y
S
G
S
F
A
R
D
Site 58
S611
P
G
G
C
G
K
K
S
P
F
G
G
L
G
T
Site 59
T618
S
P
F
G
G
L
G
T
M
K
P
E
P
A
P
Site 60
T626
M
K
P
E
P
A
P
T
S
A
G
A
S
R
A
Site 61
S627
K
P
E
P
A
P
T
S
A
G
A
S
R
A
Q
Site 62
S631
A
P
T
S
A
G
A
S
R
A
Q
A
R
L
P
Site 63
S640
A
Q
A
R
L
P
H
S
G
G
P
A
A
G
G
Site 64
S660
R
D
P
E
R
P
E
S
A
K
A
F
G
R
E
Site 65
S669
K
A
F
G
R
E
G
S
G
A
Q
G
E
A
E
Site 66
S694
A
V
A
R
Q
K
D
S
G
G
S
G
R
L
G
Site 67
S697
R
Q
K
D
S
G
G
S
G
R
L
G
P
G
L
Site 68
S710
G
L
V
D
Q
E
R
S
L
S
L
S
N
V
K
Site 69
S712
V
D
Q
E
R
S
L
S
L
S
N
V
K
G
H
Site 70
S714
Q
E
R
S
L
S
L
S
N
V
K
G
H
G
R
Site 71
S754
Q
E
K
L
L
R
E
S
K
E
L
A
D
L
A
Site 72
S767
L
A
R
L
H
P
T
S
C
A
P
N
G
L
N
Site 73
S788
G
G
P
A
L
A
G
S
G
R
W
S
A
D
P
Site 74
S792
L
A
G
S
G
R
W
S
A
D
P
A
A
H
L
Site 75
S812
L
P
R
S
G
N
A
S
M
W
L
A
G
H
P
Site 76
S826
P
Y
G
L
G
P
P
S
L
H
Q
G
M
A
P
Site 77
S845
G
L
G
G
S
L
P
S
A
Y
Q
F
V
R
D
Site 78
Y847
G
G
S
L
P
S
A
Y
Q
F
V
R
D
P
Q
Site 79
S855
Q
F
V
R
D
P
Q
S
G
Q
L
V
V
I
P
Site 80
Y886
P
P
L
W
P
A
L
Y
P
P
G
R
S
P
L
Site 81
S891
A
L
Y
P
P
G
R
S
P
L
H
H
A
Q
Q
Site 82
S903
A
Q
Q
L
Q
L
F
S
Q
Q
H
F
L
R
Q
Site 83
Y915
L
R
Q
Q
E
F
L
Y
L
Q
Q
Q
A
A
Q
Site 84
S929
Q
A
L
E
L
Q
R
S
A
Q
L
V
Q
E
R
Site 85
S951
A
E
M
E
E
K
G
S
K
R
G
L
E
A
A
Site 86
S991
G
T
Y
G
K
A
V
S
P
P
P
S
P
R
A
Site 87
S995
K
A
V
S
P
P
P
S
P
R
A
S
P
V
A
Site 88
S999
P
P
P
S
P
R
A
S
P
V
A
A
L
K
A
Site 89
S1016
I
Q
K
L
E
D
V
S
K
P
P
A
Y
A
Y
Site 90
Y1021
D
V
S
K
P
P
A
Y
A
Y
P
A
T
P
S
Site 91
Y1023
S
K
P
P
A
Y
A
Y
P
A
T
P
S
S
H
Site 92
T1026
P
A
Y
A
Y
P
A
T
P
S
S
H
P
T
S
Site 93
S1028
Y
A
Y
P
A
T
P
S
S
H
P
T
S
P
P
Site 94
S1029
A
Y
P
A
T
P
S
S
H
P
T
S
P
P
P
Site 95
T1032
A
T
P
S
S
H
P
T
S
P
P
P
A
S
P
Site 96
S1033
T
P
S
S
H
P
T
S
P
P
P
A
S
P
P
Site 97
S1038
P
T
S
P
P
P
A
S
P
P
P
T
P
G
I
Site 98
T1042
P
P
A
S
P
P
P
T
P
G
I
T
R
K
E
Site 99
S1069
E
L
E
K
E
A
P
S
P
F
Q
A
L
F
S
Site 100
S1076
S
P
F
Q
A
L
F
S
D
I
P
P
R
Y
P
Site 101
Y1082
F
S
D
I
P
P
R
Y
P
F
Q
A
L
P
P
Site 102
Y1091
F
Q
A
L
P
P
H
Y
G
R
P
Y
P
F
L
Site 103
Y1095
P
P
H
Y
G
R
P
Y
P
F
L
L
Q
P
T
Site 104
S1127
G
P
E
R
L
A
L
S
P
E
D
K
P
I
R
Site 105
S1136
E
D
K
P
I
R
L
S
P
S
K
I
T
E
P
Site 106
S1138
K
P
I
R
L
S
P
S
K
I
T
E
P
L
R
Site 107
S1217
G
Q
S
C
A
E
P
S
E
C
P
D
F
V
E
Site 108
S1232
G
P
E
P
R
V
D
S
P
G
R
T
E
P
C
Site 109
T1236
R
V
D
S
P
G
R
T
E
P
C
T
A
A
L
Site 110
T1240
P
G
R
T
E
P
C
T
A
A
L
D
L
G
V
Site 111
S1285
G
L
A
Q
V
A
P
S
E
S
Q
P
T
L
E
Site 112
S1287
A
Q
V
A
P
S
E
S
Q
P
T
L
E
M
S
Site 113
T1290
A
P
S
E
S
Q
P
T
L
E
M
S
D
C
D
Site 114
S1294
S
Q
P
T
L
E
M
S
D
C
D
V
P
A
G
Site 115
S1307
A
G
E
G
Q
C
P
S
L
E
P
Q
E
A
V
Site 116
S1327
T
C
F
L
E
E
A
S
S
D
Q
F
L
P
S
Site 117
S1334
S
S
D
Q
F
L
P
S
L
E
D
P
L
A
G
Site 118
S1359
P
Q
A
R
P
L
P
S
P
G
A
A
G
A
Q
Site 119
S1376
E
K
L
E
A
A
E
S
L
V
L
E
Q
S
F
Site 120
S1402
E
L
E
L
E
R
R
S
Q
E
M
G
G
A
E
Site 121
S1457
L
K
P
N
K
K
Y
S
W
M
R
K
K
E
E
Site 122
Y1467
R
K
K
E
E
R
M
Y
A
M
K
S
S
L
E
Site 123
S1472
R
M
Y
A
M
K
S
S
L
E
D
M
D
A
L
Site 124
Y1494
L
A
E
V
Q
R
Q
Y
K
E
K
Q
R
E
L
Site 125
S1510
K
L
Q
R
R
R
D
S
E
D
R
R
E
E
P
Site 126
S1520
R
R
E
E
P
H
R
S
L
A
R
R
G
P
G
Site 127
T1533
P
G
R
P
R
K
R
T
H
A
P
S
A
L
S
Site 128
S1537
R
K
R
T
H
A
P
S
A
L
S
P
P
R
K
Site 129
S1540
T
H
A
P
S
A
L
S
P
P
R
K
R
G
K
Site 130
S1548
P
P
R
K
R
G
K
S
G
H
S
S
G
K
L
Site 131
S1551
K
R
G
K
S
G
H
S
S
G
K
L
S
S
K
Site 132
S1552
R
G
K
S
G
H
S
S
G
K
L
S
S
K
S
Site 133
S1556
G
H
S
S
G
K
L
S
S
K
S
L
L
T
S
Site 134
S1557
H
S
S
G
K
L
S
S
K
S
L
L
T
S
D
Site 135
S1559
S
G
K
L
S
S
K
S
L
L
T
S
D
D
Y
Site 136
S1563
S
S
K
S
L
L
T
S
D
D
Y
E
L
G
A
Site 137
Y1566
S
L
L
T
S
D
D
Y
E
L
G
A
G
I
R
Site 138
T1598
K
A
R
G
R
N
Q
T
W
D
E
H
E
A
S
Site 139
S1605
T
W
D
E
H
E
A
S
S
D
F
I
S
Q
L
Site 140
S1606
W
D
E
H
E
A
S
S
D
F
I
S
Q
L
K
Site 141
S1610
E
A
S
S
D
F
I
S
Q
L
K
I
K
K
K
Site 142
S1621
I
K
K
K
K
M
A
S
D
Q
E
Q
L
A
S
Site 143
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D
E
D
S
S
C
S
Site 295
S2677
S
S
T
T
D
E
D
S
S
C
S
S
D
D
E
Site 296
S2678
S
T
T
D
E
D
S
S
C
S
S
D
D
E
A
Site 297
S2681
D
E
D
S
S
C
S
S
D
D
E
A
A
P
A
Site 298
S2713
Q
A
G
K
A
R
P
S
A
H
S
P
G
K
K
Site 299
S2716
K
A
R
P
S
A
H
S
P
G
K
K
T
P
A
Site 300
T2721
A
H
S
P
G
K
K
T
P
A
P
Q
P
Q
A
Site 301
S2747
K
A
Q
A
G
A
K
S
R
P
K
K
R
E
G
Site 302
T2760
E
G
V
H
L
P
T
T
K
E
L
A
K
R
Q
Site 303
S2771
A
K
R
Q
R
L
P
S
V
E
N
R
P
K
I
Site 304
Y2837
A
G
R
P
N
L
P
Y
I
G
R
I
Q
S
M
Site 305
Y2860
V
V
R
V
K
W
F
Y
H
P
E
E
T
S
P
Site 306
S2866
F
Y
H
P
E
E
T
S
P
G
K
Q
F
H
Q
Site 307
S2881
G
Q
H
W
D
Q
K
S
S
R
S
L
P
A
A
Site 308
S2884
W
D
Q
K
S
S
R
S
L
P
A
A
L
R
V
Site 309
S2892
L
P
A
A
L
R
V
S
S
Q
R
K
D
F
M
Site 310
S2893
P
A
A
L
R
V
S
S
Q
R
K
D
F
M
E
Site 311
Y2904
D
F
M
E
R
A
L
Y
Q
S
S
H
V
D
E
Site 312
S2906
M
E
R
A
L
Y
Q
S
S
H
V
D
E
N
D
Site 313
T2916
V
D
E
N
D
V
Q
T
V
S
H
K
C
L
V
Site 314
Y2929
L
V
V
G
L
E
Q
Y
E
Q
M
L
K
T
K
Site 315
Y2938
Q
M
L
K
T
K
K
Y
Q
D
S
E
G
L
Y
Site 316
Y2945
Y
Q
D
S
E
G
L
Y
Y
L
A
G
T
Y
E
Site 317
Y2946
Q
D
S
E
G
L
Y
Y
L
A
G
T
Y
E
P
Site 318
T2950
G
L
Y
Y
L
A
G
T
Y
E
P
T
T
G
M
Site 319
T2955
A
G
T
Y
E
P
T
T
G
M
I
F
S
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation