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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IPO8
Full Name:
Importin-8
Alias:
Imp8; Importin 8; RAN binding protein 8; RANBP8
Type:
G protein regulator, misc.
Mass (Da):
119938
Number AA:
1037
UniProt ID:
O15397
International Prot ID:
IPI00007401
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008536
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
I
I
Q
A
L
K
G
T
I
D
P
K
L
R
I
Site 2
Y30
E
N
E
L
N
Q
S
Y
K
I
I
N
F
A
P
Site 3
Y67
L
K
N
M
V
T
Q
Y
W
P
D
R
E
P
P
Site 4
Y136
G
V
V
D
K
I
D
Y
Y
L
Q
S
Q
S
S
Site 5
Y137
V
V
D
K
I
D
Y
Y
L
Q
S
Q
S
S
A
Site 6
S140
K
I
D
Y
Y
L
Q
S
Q
S
S
A
S
W
L
Site 7
S142
D
Y
Y
L
Q
S
Q
S
S
A
S
W
L
G
S
Site 8
S143
Y
Y
L
Q
S
Q
S
S
A
S
W
L
G
S
L
Site 9
Y195
Q
L
L
P
D
S
S
Y
Y
S
V
L
L
Q
K
Site 10
S197
L
P
D
S
S
Y
Y
S
V
L
L
Q
K
Q
I
Site 11
T240
F
R
T
I
I
D
R
T
V
P
P
E
T
L
H
Site 12
Y276
V
A
R
L
F
E
R
Y
G
S
P
G
N
V
T
Site 13
S278
R
L
F
E
R
Y
G
S
P
G
N
V
T
K
E
Site 14
Y286
P
G
N
V
T
K
E
Y
F
E
F
S
E
F
F
Site 15
Y312
L
L
K
I
L
D
Q
Y
R
Q
K
E
Y
V
A
Site 16
Y317
D
Q
Y
R
Q
K
E
Y
V
A
P
R
V
L
Q
Site 17
Y361
V
I
F
S
V
M
C
Y
K
D
E
D
E
E
L
Site 18
Y374
E
L
W
Q
E
D
P
Y
E
Y
I
R
M
K
F
Site 19
Y376
W
Q
E
D
P
Y
E
Y
I
R
M
K
F
D
I
Site 20
Y387
K
F
D
I
F
E
D
Y
A
S
P
T
T
A
A
Site 21
S389
D
I
F
E
D
Y
A
S
P
T
T
A
A
Q
T
Site 22
Y417
P
K
M
M
A
F
C
Y
Q
I
L
T
D
P
N
Site 23
S448
A
E
I
L
L
K
K
S
L
F
K
D
Q
M
E
Site 24
S505
A
V
E
L
A
K
K
S
L
I
E
D
K
E
M
Site 25
Y535
N
Q
I
Q
A
K
E
Y
M
K
P
H
V
R
P
Site 26
T554
L
L
H
I
V
R
E
T
E
N
D
D
V
T
N
Site 27
T560
E
T
E
N
D
D
V
T
N
V
I
Q
K
M
I
Site 28
S571
Q
K
M
I
C
E
Y
S
Q
E
V
A
S
I
A
Site 29
S595
I
F
G
K
V
L
Q
S
D
E
Y
E
E
V
E
Site 30
Y598
K
V
L
Q
S
D
E
Y
E
E
V
E
D
K
T
Site 31
T620
H
T
I
D
T
I
L
T
V
V
E
D
H
K
E
Site 32
T707
Y
V
T
I
D
T
D
T
L
L
S
N
A
K
H
Site 33
T770
Q
L
V
L
E
R
L
T
R
G
V
K
T
S
E
Site 34
S776
L
T
R
G
V
K
T
S
E
L
R
T
M
C
L
Site 35
T800
N
P
D
L
L
L
H
T
L
E
R
I
Q
L
P
Site 36
T878
G
L
K
Q
V
C
A
T
R
Q
L
V
N
R
E
Site 37
S902
M
E
E
N
E
E
I
S
S
D
E
E
E
T
N
Site 38
S903
E
E
N
E
E
I
S
S
D
E
E
E
T
N
V
Site 39
T908
I
S
S
D
E
E
E
T
N
V
T
A
Q
A
M
Site 40
T911
D
E
E
E
T
N
V
T
A
Q
A
M
Q
S
N
Site 41
T947
T
A
L
E
G
F
S
T
P
L
D
L
D
N
S
Site 42
S954
T
P
L
D
L
D
N
S
V
D
E
Y
Q
F
F
Site 43
Y958
L
D
N
S
V
D
E
Y
Q
F
F
T
Q
A
L
Site 44
Y976
Q
S
R
D
A
A
W
Y
Q
L
L
M
A
P
L
Site 45
S984
Q
L
L
M
A
P
L
S
E
D
Q
R
T
A
L
Site 46
T989
P
L
S
E
D
Q
R
T
A
L
Q
E
V
Y
T
Site 47
T1003
T
L
A
E
H
R
R
T
V
A
E
A
K
K
K
Site 48
T1018
I
E
Q
Q
G
G
F
T
F
E
N
K
G
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation