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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF3S3
Full Name:
Eukaryotic translation initiation factor 3 subunit H
Alias:
EIF3-gamma; EIF3h; EIF3-p40; Eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; Eukaryotic translation initiation factor 3, subunit H; MGC102958
Type:
Translation protein, initiation complex
Mass (Da):
39930
Number AA:
352
UniProt ID:
O15372
International Prot ID:
IPI00647650
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006446
GO:0006413
GO:0006446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
S
R
K
E
G
T
G
S
T
A
T
S
S
Site 2
S10
S
R
K
E
G
T
G
S
T
A
T
S
S
S
S
Site 3
T11
R
K
E
G
T
G
S
T
A
T
S
S
S
S
T
Site 4
T13
E
G
T
G
S
T
A
T
S
S
S
S
T
A
G
Site 5
S14
G
T
G
S
T
A
T
S
S
S
S
T
A
G
A
Site 6
S15
T
G
S
T
A
T
S
S
S
S
T
A
G
A
A
Site 7
S17
S
T
A
T
S
S
S
S
T
A
G
A
A
G
K
Site 8
S31
K
G
K
G
K
G
G
S
G
D
S
A
V
K
Q
Site 9
S34
G
K
G
G
S
G
D
S
A
V
K
Q
V
Q
I
Site 10
Y53
V
L
K
I
I
K
H
Y
Q
E
E
G
Q
G
T
Site 11
T60
Y
Q
E
E
G
Q
G
T
E
V
V
Q
G
V
L
Site 12
Y120
D
H
L
H
V
G
W
Y
Q
S
T
Y
Y
G
S
Site 13
Y124
V
G
W
Y
Q
S
T
Y
Y
G
S
F
V
T
R
Site 14
Y125
G
W
Y
Q
S
T
Y
Y
G
S
F
V
T
R
A
Site 15
S127
Y
Q
S
T
Y
Y
G
S
F
V
T
R
A
L
L
Site 16
S136
V
T
R
A
L
L
D
S
Q
F
S
Y
Q
H
A
Site 17
Y140
L
L
D
S
Q
F
S
Y
Q
H
A
I
E
E
S
Site 18
Y152
E
E
S
V
V
L
I
Y
D
P
I
K
T
A
Q
Site 19
S161
P
I
K
T
A
Q
G
S
L
S
L
K
A
Y
R
Site 20
S163
K
T
A
Q
G
S
L
S
L
K
A
Y
R
L
T
Site 21
S183
V
C
K
E
K
D
F
S
P
E
A
L
K
K
A
Site 22
T193
A
L
K
K
A
N
I
T
F
E
Y
M
F
E
E
Site 23
S222
M
W
E
L
E
K
K
S
A
V
A
D
K
H
E
Site 24
S232
A
D
K
H
E
L
L
S
L
A
S
S
N
H
L
Site 25
S236
E
L
L
S
L
A
S
S
N
H
L
G
K
N
L
Site 26
Y263
D
I
V
K
Y
N
T
Y
M
R
N
T
S
K
Q
Site 27
S290
Q
E
N
M
Q
R
Q
S
R
G
E
P
P
L
P
Site 28
S302
P
L
P
E
E
D
L
S
K
L
F
K
P
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation