KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FANCA
Full Name:
Fanconi anemia group A protein
Alias:
FA; Fa; FA1; FAA; FACA; FAH; FA-H; FANCH; Fanconi anemia, complementation group A
Type:
DNA repair
Mass (Da):
162775
Number AA:
1455
UniProt ID:
O15360
International Prot ID:
IPI00006170
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
D
S
W
V
P
N
S
A
S
G
Q
D
P
G
Site 2
S11
S
W
V
P
N
S
A
S
G
Q
D
P
G
G
R
Site 3
Y35
G
R
V
K
R
E
K
Y
N
P
E
R
A
Q
K
Site 4
S46
R
A
Q
K
L
K
E
S
A
V
R
L
L
R
S
Site 5
S53
S
A
V
R
L
L
R
S
H
Q
D
L
N
A
L
Site 6
S82
S
K
V
I
D
C
D
S
S
E
A
Y
A
N
H
Site 7
S83
K
V
I
D
C
D
S
S
E
A
Y
A
N
H
S
Site 8
Y86
D
C
D
S
S
E
A
Y
A
N
H
S
S
S
F
Site 9
S90
S
E
A
Y
A
N
H
S
S
S
F
I
G
S
A
Site 10
S92
A
Y
A
N
H
S
S
S
F
I
G
S
A
L
Q
Site 11
S96
H
S
S
S
F
I
G
S
A
L
Q
D
Q
A
S
Site 12
S103
S
A
L
Q
D
Q
A
S
R
L
G
V
P
V
G
Site 13
T138
T
S
H
P
V
L
L
T
V
E
Q
R
K
K
L
Site 14
S147
E
Q
R
K
K
L
S
S
L
L
E
F
A
Q
Y
Site 15
S199
S
L
Q
E
L
L
E
S
H
P
D
M
H
A
V
Site 16
S251
L
R
G
F
Q
K
N
S
D
L
R
R
T
V
E
Site 17
T256
K
N
S
D
L
R
R
T
V
E
P
E
K
M
P
Site 18
T291
G
V
Q
E
E
S
S
T
H
K
I
V
R
C
W
Site 19
S312
H
T
L
G
S
V
I
S
T
D
P
L
K
R
F
Site 20
S321
D
P
L
K
R
F
F
S
H
T
L
T
Q
I
L
Site 21
T323
L
K
R
F
F
S
H
T
L
T
Q
I
L
T
H
Site 22
T325
R
F
F
S
H
T
L
T
Q
I
L
T
H
S
P
Site 23
T329
H
T
L
T
Q
I
L
T
H
S
P
V
L
K
A
Site 24
S337
H
S
P
V
L
K
A
S
D
A
V
Q
M
Q
R
Site 25
S347
V
Q
M
Q
R
E
W
S
F
A
R
T
H
P
L
Site 26
T351
R
E
W
S
F
A
R
T
H
P
L
L
T
S
L
Site 27
S357
R
T
H
P
L
L
T
S
L
Y
R
R
L
F
V
Site 28
T381
H
L
Q
E
V
L
E
T
Q
E
V
H
W
Q
R
Site 29
S421
L
M
A
Q
A
F
E
S
C
Q
L
D
S
M
V
Site 30
S447
E
G
P
S
A
F
L
S
Y
A
D
W
F
K
A
Site 31
S458
W
F
K
A
S
F
G
S
T
R
G
Y
H
G
C
Site 32
T459
F
K
A
S
F
G
S
T
R
G
Y
H
G
C
S
Site 33
Y462
S
F
G
S
T
R
G
Y
H
G
C
S
K
K
A
Site 34
S485
S
E
L
V
P
F
E
S
P
R
Y
L
Q
V
H
Site 35
Y488
V
P
F
E
S
P
R
Y
L
Q
V
H
I
L
H
Site 36
Y503
P
P
L
V
P
G
K
Y
R
S
L
L
T
D
Y
Site 37
S505
L
V
P
G
K
Y
R
S
L
L
T
D
Y
I
S
Site 38
T508
G
K
Y
R
S
L
L
T
D
Y
I
S
L
A
K
Site 39
Y510
Y
R
S
L
L
T
D
Y
I
S
L
A
K
T
R
Site 40
Y531
S
I
E
N
M
G
L
Y
E
D
L
S
S
A
G
Site 41
S535
M
G
L
Y
E
D
L
S
S
A
G
D
I
T
E
Site 42
S536
G
L
Y
E
D
L
S
S
A
G
D
I
T
E
P
Site 43
T541
L
S
S
A
G
D
I
T
E
P
H
S
Q
A
L
Site 44
S545
G
D
I
T
E
P
H
S
Q
A
L
Q
D
V
E
Site 45
Y578
A
S
I
F
R
R
P
Y
Y
V
S
H
F
L
P
Site 46
Y579
S
I
F
R
R
P
Y
Y
V
S
H
F
L
P
A
Site 47
S606
S
R
V
A
F
I
E
S
L
K
R
A
D
K
I
Site 48
S616
R
A
D
K
I
P
P
S
L
Y
S
T
Y
C
Q
Site 49
Y618
D
K
I
P
P
S
L
Y
S
T
Y
C
Q
A
C
Site 50
S619
K
I
P
P
S
L
Y
S
T
Y
C
Q
A
C
S
Site 51
S626
S
T
Y
C
Q
A
C
S
A
A
E
E
K
P
E
Site 52
S645
G
V
R
A
E
P
N
S
A
E
E
P
L
G
Q
Site 53
S663
A
L
G
E
L
R
A
S
M
T
D
P
S
Q
R
Site 54
T665
G
E
L
R
A
S
M
T
D
P
S
Q
R
D
V
Site 55
S668
R
A
S
M
T
D
P
S
Q
R
D
V
I
S
A
Site 56
S695
L
G
H
N
E
D
D
S
S
V
E
I
S
K
I
Site 57
S696
G
H
N
E
D
D
S
S
V
E
I
S
K
I
Q
Site 58
S700
D
D
S
S
V
E
I
S
K
I
Q
L
S
I
N
Site 59
S705
E
I
S
K
I
Q
L
S
I
N
T
P
R
L
E
Site 60
T708
K
I
Q
L
S
I
N
T
P
R
L
E
P
R
E
Site 61
S735
Q
N
L
M
A
A
S
S
V
A
P
P
E
R
Q
Site 62
S775
L
L
R
H
Q
G
P
S
L
S
A
P
H
V
L
Site 63
S777
R
H
Q
G
P
S
L
S
A
P
H
V
L
G
L
Site 64
S796
V
H
L
G
E
S
R
S
A
L
P
E
V
D
V
Site 65
S850
Y
S
L
C
K
F
S
S
Q
S
R
D
T
L
C
Site 66
S852
L
C
K
F
S
S
Q
S
R
D
T
L
C
S
C
Site 67
T855
F
S
S
Q
S
R
D
T
L
C
S
C
L
S
P
Site 68
S884
S
E
A
R
Q
P
L
S
E
E
D
V
A
S
L
Site 69
S890
L
S
E
E
D
V
A
S
L
S
W
R
P
L
H
Site 70
S892
E
E
D
V
A
S
L
S
W
R
P
L
H
L
P
Site 71
T915
L
S
L
W
T
H
R
T
F
R
E
V
L
K
E
Site 72
Y929
E
E
D
V
H
L
T
Y
Q
D
W
L
H
L
E
Site 73
S947
Q
P
E
A
D
A
L
S
D
T
E
R
Q
D
F
Site 74
T949
E
A
D
A
L
S
D
T
E
R
Q
D
F
H
Q
Site 75
S967
H
E
H
F
L
P
E
S
S
A
S
G
G
C
D
Site 76
S968
E
H
F
L
P
E
S
S
A
S
G
G
C
D
G
Site 77
S970
F
L
P
E
S
S
A
S
G
G
C
D
G
D
L
Site 78
S994
A
L
M
D
F
H
Q
S
S
R
S
Y
D
H
S
Site 79
S995
L
M
D
F
H
Q
S
S
R
S
Y
D
H
S
E
Site 80
S997
D
F
H
Q
S
S
R
S
Y
D
H
S
E
N
S
Site 81
Y998
F
H
Q
S
S
R
S
Y
D
H
S
E
N
S
D
Site 82
S1001
S
S
R
S
Y
D
H
S
E
N
S
D
L
V
F
Site 83
S1004
S
Y
D
H
S
E
N
S
D
L
V
F
G
G
R
Site 84
S1019
T
G
N
E
D
I
I
S
R
L
Q
E
M
V
A
Site 85
S1043
V
P
L
G
H
T
P
S
Q
E
H
F
L
F
E
Site 86
T1060
R
R
R
L
Q
A
L
T
S
G
W
S
V
A
A
Site 87
S1061
R
R
L
Q
A
L
T
S
G
W
S
V
A
A
S
Site 88
S1064
Q
A
L
T
S
G
W
S
V
A
A
S
L
Q
R
Site 89
S1068
S
G
W
S
V
A
A
S
L
Q
R
Q
R
E
L
Site 90
Y1078
R
Q
R
E
L
L
M
Y
K
R
I
L
L
R
L
Site 91
T1127
C
S
H
G
G
A
L
T
Q
D
I
T
A
H
F
Site 92
S1149
C
L
R
S
R
D
P
S
L
M
V
D
F
I
L
Site 93
S1191
R
W
R
R
H
C
Q
S
P
L
P
R
E
L
Q
Site 94
S1208
Q
E
G
R
Q
F
A
S
D
F
L
S
P
E
A
Site 95
S1212
Q
F
A
S
D
F
L
S
P
E
A
A
S
P
A
Site 96
S1217
F
L
S
P
E
A
A
S
P
A
P
N
P
D
W
Site 97
T1274
G
L
L
S
S
H
L
T
S
N
S
T
T
D
L
Site 98
S1275
L
L
S
S
H
L
T
S
N
S
T
T
D
L
P
Site 99
S1277
S
S
H
L
T
S
N
S
T
T
D
L
P
K
A
Site 100
T1279
H
L
T
S
N
S
T
T
D
L
P
K
A
F
H
Site 101
S1301
C
L
E
K
R
K
I
S
W
L
A
L
F
Q
L
Site 102
T1309
W
L
A
L
F
Q
L
T
E
S
D
L
R
L
G
Site 103
T1375
F
V
A
G
D
T
S
T
V
S
P
P
A
G
R
Site 104
S1377
A
G
D
T
S
T
V
S
P
P
A
G
R
S
L
Site 105
S1383
V
S
P
P
A
G
R
S
L
E
L
K
G
Q
G
Site 106
S1414
I
P
R
C
P
K
K
S
F
S
H
V
A
E
L
Site 107
S1416
R
C
P
K
K
S
F
S
H
V
A
E
L
L
A
Site 108
S1449
A
A
P
D
A
D
L
S
Q
E
P
H
L
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation