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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPHP1
Full Name:
Nephrocystin-1
Alias:
Juvenile nephronophthisis 1 protein
Type:
Mass (Da):
83299
Number AA:
732
UniProt ID:
O15259
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
E
L
K
Q
Q
V
D
S
L
L
S
E
S
Q
L
Site 2
S29
Q
Q
V
D
S
L
L
S
E
S
Q
L
K
E
A
Site 3
Y46
P
N
K
R
Q
H
I
Y
Q
R
C
I
Q
L
K
Site 4
S67
K
N
A
L
Q
K
L
S
K
A
D
E
S
A
P
Site 5
T87
Q
R
K
E
E
E
H
T
L
L
D
K
L
T
Q
Site 6
T93
H
T
L
L
D
K
L
T
Q
Q
L
Q
G
L
A
Site 7
S121
P
T
E
E
E
E
E
S
E
S
E
D
S
E
D
Site 8
S123
E
E
E
E
E
S
E
S
E
D
S
E
D
S
G
Site 9
S126
E
E
S
E
S
E
D
S
E
D
S
G
G
E
E
Site 10
S148
E
E
K
E
E
N
E
S
H
K
W
S
T
G
E
Site 11
S152
E
N
E
S
H
K
W
S
T
G
E
E
Y
I
A
Site 12
Y157
K
W
S
T
G
E
E
Y
I
A
V
G
D
F
T
Site 13
T172
A
Q
Q
V
G
D
L
T
F
K
K
G
E
I
L
Site 14
Y206
E
G
L
V
P
R
T
Y
L
E
P
Y
S
E
E
Site 15
S211
R
T
Y
L
E
P
Y
S
E
E
E
E
G
Q
E
Site 16
S219
E
E
E
E
G
Q
E
S
S
E
E
G
S
E
E
Site 17
S220
E
E
E
G
Q
E
S
S
E
E
G
S
E
E
D
Site 18
S224
Q
E
S
S
E
E
G
S
E
E
D
V
E
A
V
Site 19
T282
L
M
R
N
R
M
E
T
V
E
D
T
N
G
S
Site 20
T286
R
M
E
T
V
E
D
T
N
G
S
E
T
G
F
Site 21
S289
T
V
E
D
T
N
G
S
E
T
G
F
R
A
W
Site 22
T316
K
P
V
L
Q
I
N
T
V
D
V
L
T
T
M
Site 23
T334
P
A
G
F
R
P
S
T
L
S
Q
L
L
E
E
Site 24
S336
G
F
R
P
S
T
L
S
Q
L
L
E
E
G
N
Site 25
Y349
G
N
Q
F
R
A
N
Y
F
L
Q
P
E
L
M
Site 26
S358
L
Q
P
E
L
M
P
S
Q
L
A
F
R
D
L
Site 27
T370
R
D
L
M
W
D
A
T
E
G
T
I
R
S
R
Site 28
T373
M
W
D
A
T
E
G
T
I
R
S
R
P
S
R
Site 29
S376
A
T
E
G
T
I
R
S
R
P
S
R
I
S
L
Site 30
S379
G
T
I
R
S
R
P
S
R
I
S
L
I
L
T
Site 31
S382
R
S
R
P
S
R
I
S
L
I
L
T
L
W
S
Site 32
T386
S
R
I
S
L
I
L
T
L
W
S
C
K
M
I
Site 33
S419
F
D
G
N
K
V
L
S
N
I
H
T
V
R
A
Site 34
T423
K
V
L
S
N
I
H
T
V
R
A
T
W
Q
P
Site 35
T427
N
I
H
T
V
R
A
T
W
Q
P
K
K
P
K
Site 36
T435
W
Q
P
K
K
P
K
T
W
T
F
S
P
Q
V
Site 37
T437
P
K
K
P
K
T
W
T
F
S
P
Q
V
T
R
Site 38
S439
K
P
K
T
W
T
F
S
P
Q
V
T
R
I
L
Site 39
S458
D
G
D
C
F
I
R
S
N
S
A
S
P
D
L
Site 40
S460
D
C
F
I
R
S
N
S
A
S
P
D
L
G
I
Site 41
S474
I
L
F
E
L
G
I
S
Y
I
R
N
S
T
G
Site 42
Y475
L
F
E
L
G
I
S
Y
I
R
N
S
T
G
E
Site 43
S479
G
I
S
Y
I
R
N
S
T
G
E
R
G
E
L
Site 44
T480
I
S
Y
I
R
N
S
T
G
E
R
G
E
L
S
Site 45
S487
T
G
E
R
G
E
L
S
C
G
W
V
F
L
K
Site 46
S499
F
L
K
L
F
D
A
S
G
V
P
I
P
A
K
Site 47
T516
E
L
F
L
N
G
G
T
P
Y
E
K
G
I
E
Site 48
S527
K
G
I
E
V
D
P
S
I
S
R
R
A
H
G
Site 49
S529
I
E
V
D
P
S
I
S
R
R
A
H
G
S
V
Site 50
Y538
R
A
H
G
S
V
F
Y
Q
I
M
T
M
R
R
Site 51
T542
S
V
F
Y
Q
I
M
T
M
R
R
Q
P
Q
L
Site 52
S555
Q
L
L
V
K
L
R
S
L
N
R
R
S
R
N
Site 53
S560
L
R
S
L
N
R
R
S
R
N
V
L
S
L
L
Site 54
S565
R
R
S
R
N
V
L
S
L
L
P
E
T
L
I
Site 55
S601
K
D
R
M
S
L
Q
S
T
D
L
I
S
H
P
Site 56
T602
D
R
M
S
L
Q
S
T
D
L
I
S
H
P
M
Site 57
S629
V
M
D
A
L
R
S
S
W
A
G
K
E
S
T
Site 58
S635
S
S
W
A
G
K
E
S
T
L
K
R
S
E
K
Site 59
T636
S
W
A
G
K
E
S
T
L
K
R
S
E
K
R
Site 60
S650
R
D
K
E
F
L
K
S
T
F
L
L
V
Y
H
Site 61
T651
D
K
E
F
L
K
S
T
F
L
L
V
Y
H
D
Site 62
T667
V
L
P
L
L
H
S
T
R
L
P
P
F
R
W
Site 63
T681
W
A
E
E
E
T
E
T
A
R
W
K
V
I
T
Site 64
T688
T
A
R
W
K
V
I
T
D
F
L
K
Q
N
Q
Site 65
S706
G
A
L
Q
A
L
L
S
P
D
G
V
H
E
P
Site 66
S717
V
H
E
P
F
D
L
S
E
Q
T
Y
D
F
L
Site 67
Y721
F
D
L
S
E
Q
T
Y
D
F
L
G
E
M
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation