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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASC3
Full Name:
Protein CASC3
Alias:
Barentsz protein; Btz; Cancer susceptibility candidate 3; Cancer susceptibility candidate gene 3 protein; Metastatic lymph node protein 51; MLN51; Protein barentsz
Type:
RNA binding protein
Mass (Da):
76278
Number AA:
703
UniProt ID:
O15234
International Prot ID:
IPI00289491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
GO:0048471
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0042802
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0051028
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
R
Q
R
A
S
Q
D
T
E
D
E
E
S
G
A
Site 2
S18
Q
D
T
E
D
E
E
S
G
A
S
G
S
D
S
Site 3
S21
E
D
E
E
S
G
A
S
G
S
D
S
G
G
S
Site 4
S23
E
E
S
G
A
S
G
S
D
S
G
G
S
P
L
Site 5
S25
S
G
A
S
G
S
D
S
G
G
S
P
L
R
G
Site 6
S28
S
G
S
D
S
G
G
S
P
L
R
G
G
G
S
Site 7
S35
S
P
L
R
G
G
G
S
C
S
G
S
A
G
G
Site 8
S37
L
R
G
G
G
S
C
S
G
S
A
G
G
G
G
Site 9
S39
G
G
G
S
C
S
G
S
A
G
G
G
G
S
G
Site 10
S45
G
S
A
G
G
G
G
S
G
S
L
P
S
Q
R
Site 11
S47
A
G
G
G
G
S
G
S
L
P
S
Q
R
G
G
Site 12
S50
G
G
S
G
S
L
P
S
Q
R
G
G
R
T
G
Site 13
S66
L
H
L
R
R
V
E
S
G
G
A
K
S
A
E
Site 14
S71
V
E
S
G
G
A
K
S
A
E
E
S
E
C
E
Site 15
S75
G
A
K
S
A
E
E
S
E
C
E
S
E
D
G
Site 16
S79
A
E
E
S
E
C
E
S
E
D
G
I
E
G
D
Site 17
S90
I
E
G
D
A
V
L
S
D
Y
E
S
A
E
D
Site 18
Y92
G
D
A
V
L
S
D
Y
E
S
A
E
D
S
E
Site 19
S94
A
V
L
S
D
Y
E
S
A
E
D
S
E
G
E
Site 20
S98
D
Y
E
S
A
E
D
S
E
G
E
E
G
E
Y
Site 21
Y105
S
E
G
E
E
G
E
Y
S
E
E
E
N
S
K
Site 22
S106
E
G
E
E
G
E
Y
S
E
E
E
N
S
K
V
Site 23
S111
E
Y
S
E
E
E
N
S
K
V
E
L
K
S
E
Site 24
S117
N
S
K
V
E
L
K
S
E
A
N
D
A
V
N
Site 25
S125
E
A
N
D
A
V
N
S
S
T
K
E
E
K
G
Site 26
T138
K
G
E
E
K
P
D
T
K
S
T
V
T
G
E
Site 27
S140
E
E
K
P
D
T
K
S
T
V
T
G
E
R
Q
Site 28
T141
E
K
P
D
T
K
S
T
V
T
G
E
R
Q
S
Site 29
T143
P
D
T
K
S
T
V
T
G
E
R
Q
S
G
D
Site 30
S148
T
V
T
G
E
R
Q
S
G
D
G
Q
E
S
T
Site 31
T155
S
G
D
G
Q
E
S
T
E
P
V
E
N
K
V
Site 32
Y181
E
D
R
K
N
P
A
Y
I
P
R
K
G
L
F
Site 33
T197
E
H
D
L
R
G
Q
T
Q
E
E
E
V
R
P
Site 34
S232
E
D
E
Q
A
P
K
S
R
Q
E
L
I
A
L
Site 35
Y240
R
Q
E
L
I
A
L
Y
G
Y
D
I
R
S
A
Site 36
Y242
E
L
I
A
L
Y
G
Y
D
I
R
S
A
H
N
Site 37
Y263
R
R
I
R
K
P
R
Y
G
S
P
P
Q
R
D
Site 38
S265
I
R
K
P
R
Y
G
S
P
P
Q
R
D
P
N
Site 39
S281
N
G
E
R
L
N
K
S
H
R
H
Q
G
L
G
Site 40
T290
R
H
Q
G
L
G
G
T
L
P
P
R
T
F
I
Site 41
T295
G
G
T
L
P
P
R
T
F
I
N
R
N
A
A
Site 42
T304
I
N
R
N
A
A
G
T
G
R
M
S
A
P
R
Site 43
S308
A
A
G
T
G
R
M
S
A
P
R
N
Y
S
R
Site 44
Y313
R
M
S
A
P
R
N
Y
S
R
S
G
G
F
K
Site 45
S314
M
S
A
P
R
N
Y
S
R
S
G
G
F
K
E
Site 46
S316
A
P
R
N
Y
S
R
S
G
G
F
K
E
G
R
Site 47
S339
G
G
Q
H
G
G
R
S
G
E
T
V
K
H
E
Site 48
T342
H
G
G
R
S
G
E
T
V
K
H
E
I
S
Y
Site 49
S348
E
T
V
K
H
E
I
S
Y
R
S
R
R
L
E
Site 50
S351
K
H
E
I
S
Y
R
S
R
R
L
E
Q
T
S
Site 51
T357
R
S
R
R
L
E
Q
T
S
V
R
D
P
S
P
Site 52
S358
S
R
R
L
E
Q
T
S
V
R
D
P
S
P
E
Site 53
S363
Q
T
S
V
R
D
P
S
P
E
A
D
A
P
V
Site 54
S373
A
D
A
P
V
L
G
S
P
E
K
E
E
A
A
Site 55
S381
P
E
K
E
E
A
A
S
E
P
P
A
A
A
P
Site 56
S403
D
R
P
I
E
K
K
S
Y
S
R
A
R
R
T
Site 57
Y404
R
P
I
E
K
K
S
Y
S
R
A
R
R
T
R
Site 58
S405
P
I
E
K
K
S
Y
S
R
A
R
R
T
R
T
Site 59
T410
S
Y
S
R
A
R
R
T
R
T
K
V
G
D
A
Site 60
T412
S
R
A
R
R
T
R
T
K
V
G
D
A
V
K
Site 61
T440
P
A
P
P
V
P
E
T
T
P
T
P
P
T
K
Site 62
T441
A
P
P
V
P
E
T
T
P
T
P
P
T
K
T
Site 63
T443
P
V
P
E
T
T
P
T
P
P
T
K
T
G
T
Site 64
S457
T
W
E
A
P
V
D
S
S
T
S
G
L
E
Q
Site 65
S477
N
I
A
E
Q
N
W
S
P
G
Q
P
S
F
L
Site 66
S482
N
W
S
P
G
Q
P
S
F
L
Q
P
R
E
L
Site 67
Y522
Q
G
G
R
A
K
R
Y
S
S
Q
R
Q
R
P
Site 68
S523
G
G
R
A
K
R
Y
S
S
Q
R
Q
R
P
V
Site 69
S524
G
R
A
K
R
Y
S
S
Q
R
Q
R
P
V
P
Site 70
Y547
I
S
I
M
E
G
H
Y
Y
D
P
L
Q
F
Q
Site 71
Y548
S
I
M
E
G
H
Y
Y
D
P
L
Q
F
Q
G
Site 72
Y558
L
Q
F
Q
G
P
I
Y
T
H
G
D
S
P
A
Site 73
T559
Q
F
Q
G
P
I
Y
T
H
G
D
S
P
A
P
Site 74
S563
P
I
Y
T
H
G
D
S
P
A
P
L
P
P
Q
Site 75
T590
P
G
L
H
P
H
Q
T
P
A
P
L
P
N
P
Site 76
Y600
P
L
P
N
P
G
L
Y
P
P
P
V
S
M
S
Site 77
S605
G
L
Y
P
P
P
V
S
M
S
P
G
Q
P
P
Site 78
S607
Y
P
P
P
V
S
M
S
P
G
Q
P
P
P
Q
Site 79
S634
V
M
N
F
G
N
P
S
Y
P
Y
A
P
G
A
Site 80
Y635
M
N
F
G
N
P
S
Y
P
Y
A
P
G
A
L
Site 81
Y637
F
G
N
P
S
Y
P
Y
A
P
G
A
L
P
P
Site 82
Y651
P
P
P
P
P
H
L
Y
P
N
T
Q
A
P
S
Site 83
T654
P
P
H
L
Y
P
N
T
Q
A
P
S
Q
V
Y
Site 84
S658
Y
P
N
T
Q
A
P
S
Q
V
Y
G
G
V
T
Site 85
Y666
Q
V
Y
G
G
V
T
Y
Y
N
P
A
Q
Q
Q
Site 86
Y667
V
Y
G
G
V
T
Y
Y
N
P
A
Q
Q
Q
V
Site 87
S679
Q
Q
V
Q
P
K
P
S
P
P
R
R
T
P
Q
Site 88
T684
K
P
S
P
P
R
R
T
P
Q
P
V
T
I
K
Site 89
T689
R
R
T
P
Q
P
V
T
I
K
P
P
P
P
E
Site 90
S699
P
P
P
P
E
V
V
S
R
G
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation