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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RGL2
Full Name:
Ral guanine nucleotide dissociation stimulator-like 2
Alias:
GDS-related protein; HKE1.5; KE1.5; RAB2, member RAS oncogene family-like; RAB2L; RalGDS-like factor; RAS-associated protein RAB2L
Type:
Guanine nucleotide exchange factor, Ras
Mass (Da):
83549
Number AA:
777
UniProt ID:
O15211
International Prot ID:
IPI00005656
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005088
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
R
L
L
L
D
T
S
P
P
G
G
V
V
L
Site 2
S21
P
P
G
G
V
V
L
S
S
F
R
S
R
D
P
Site 3
S22
P
G
G
V
V
L
S
S
F
R
S
R
D
P
E
Site 4
S25
V
V
L
S
S
F
R
S
R
D
P
E
E
G
G
Site 5
S56
E
E
E
E
A
P
V
S
V
W
D
E
E
E
D
Site 6
T68
E
E
D
G
A
V
F
T
V
T
S
R
Q
Y
R
Site 7
T70
D
G
A
V
F
T
V
T
S
R
Q
Y
R
P
L
Site 8
Y74
F
T
V
T
S
R
Q
Y
R
P
L
D
P
L
V
Site 9
S88
V
P
M
P
P
P
R
S
S
R
R
L
R
A
G
Site 10
S89
P
M
P
P
P
R
S
S
R
R
L
R
A
G
T
Site 11
T96
S
R
R
L
R
A
G
T
L
E
A
L
V
R
H
Site 12
T107
L
V
R
H
L
L
D
T
R
T
S
G
T
D
V
Site 13
T109
R
H
L
L
D
T
R
T
S
G
T
D
V
S
F
Site 14
S146
D
R
L
E
A
L
E
S
H
P
T
D
E
L
E
Site 15
T149
E
A
L
E
S
H
P
T
D
E
L
E
R
T
T
Site 16
T155
P
T
D
E
L
E
R
T
T
E
V
A
I
S
V
Site 17
T156
T
D
E
L
E
R
T
T
E
V
A
I
S
V
L
Site 18
S176
S
H
P
E
D
F
G
S
E
A
K
G
Q
L
D
Site 19
S187
G
Q
L
D
R
L
E
S
F
L
L
Q
T
G
Y
Site 20
T252
D
H
L
A
E
Q
L
T
L
L
D
A
E
L
F
Site 21
S286
G
H
S
H
L
C
P
S
V
R
A
T
V
T
Q
Site 22
S310
S
S
V
L
G
A
T
S
T
G
E
G
P
G
E
Site 23
T311
S
V
L
G
A
T
S
T
G
E
G
P
G
E
V
Site 24
T319
G
E
G
P
G
E
V
T
I
R
P
L
R
P
P
Site 25
T374
R
A
A
W
G
E
A
T
R
D
S
L
R
V
F
Site 26
S377
W
G
E
A
T
R
D
S
L
R
V
F
S
S
L
Site 27
S389
S
S
L
C
Q
I
F
S
E
E
D
N
Y
S
Q
Site 28
Y394
I
F
S
E
E
D
N
Y
S
Q
S
R
E
L
L
Site 29
S395
F
S
E
E
D
N
Y
S
Q
S
R
E
L
L
V
Site 30
S409
V
Q
E
V
K
L
Q
S
P
L
E
P
H
S
K
Site 31
S415
Q
S
P
L
E
P
H
S
K
K
A
P
R
S
G
Site 32
S421
H
S
K
K
A
P
R
S
G
S
R
G
G
G
V
Site 33
S423
K
K
A
P
R
S
G
S
R
G
G
G
V
V
P
Site 34
Y431
R
G
G
G
V
V
P
Y
L
G
T
F
L
K
D
Site 35
T434
G
V
V
P
Y
L
G
T
F
L
K
D
L
V
M
Site 36
S446
L
V
M
L
D
A
A
S
K
D
E
L
E
N
G
Site 37
Y454
K
D
E
L
E
N
G
Y
I
N
F
D
K
R
R
Site 38
S468
R
K
E
F
A
V
L
S
E
L
R
R
L
Q
N
Site 39
Y480
L
Q
N
E
C
R
G
Y
N
L
Q
P
D
H
D
Site 40
T499
L
Q
G
L
R
P
L
T
E
A
Q
S
H
R
V
Site 41
S503
R
P
L
T
E
A
Q
S
H
R
V
S
C
E
V
Site 42
S507
E
A
Q
S
H
R
V
S
C
E
V
E
P
P
G
Site 43
S515
C
E
V
E
P
P
G
S
S
D
P
P
A
P
R
Site 44
S516
E
V
E
P
P
G
S
S
D
P
P
A
P
R
V
Site 45
S548
G
V
P
T
P
L
V
S
C
D
R
P
S
T
G
Site 46
S553
L
V
S
C
D
R
P
S
T
G
G
D
E
A
P
Site 47
T554
V
S
C
D
R
P
S
T
G
G
D
E
A
P
T
Site 48
T562
G
G
D
E
A
P
T
T
P
A
P
L
L
T
R
Site 49
S578
A
Q
H
M
K
W
P
S
V
S
S
L
D
S
A
Site 50
S580
H
M
K
W
P
S
V
S
S
L
D
S
A
L
E
Site 51
S581
M
K
W
P
S
V
S
S
L
D
S
A
L
E
S
Site 52
S584
P
S
V
S
S
L
D
S
A
L
E
S
S
P
S
Site 53
S588
S
L
D
S
A
L
E
S
S
P
S
L
H
S
P
Site 54
S589
L
D
S
A
L
E
S
S
P
S
L
H
S
P
A
Site 55
S591
S
A
L
E
S
S
P
S
L
H
S
P
A
D
P
Site 56
S594
E
S
S
P
S
L
H
S
P
A
D
P
S
H
L
Site 57
S599
L
H
S
P
A
D
P
S
H
L
S
P
P
A
S
Site 58
S602
P
A
D
P
S
H
L
S
P
P
A
S
S
P
R
Site 59
S606
S
H
L
S
P
P
A
S
S
P
R
P
S
R
G
Site 60
S607
H
L
S
P
P
A
S
S
P
R
P
S
R
G
H
Site 61
S611
P
A
S
S
P
R
P
S
R
G
H
R
R
S
A
Site 62
S617
P
S
R
G
H
R
R
S
A
S
C
G
S
P
L
Site 63
S619
R
G
H
R
R
S
A
S
C
G
S
P
L
S
G
Site 64
S622
R
R
S
A
S
C
G
S
P
L
S
G
G
A
E
Site 65
S625
A
S
C
G
S
P
L
S
G
G
A
E
E
A
S
Site 66
S632
S
G
G
A
E
E
A
S
G
G
T
G
Y
G
G
Site 67
Y637
E
A
S
G
G
T
G
Y
G
G
E
G
S
G
P
Site 68
S642
T
G
Y
G
G
E
G
S
G
P
G
A
S
D
C
Site 69
S647
E
G
S
G
P
G
A
S
D
C
R
I
I
R
V
Site 70
S667
E
D
G
S
V
Y
K
S
I
L
V
T
S
Q
D
Site 71
T671
V
Y
K
S
I
L
V
T
S
Q
D
K
A
P
S
Site 72
S672
Y
K
S
I
L
V
T
S
Q
D
K
A
P
S
V
Site 73
S678
T
S
Q
D
K
A
P
S
V
I
S
R
V
L
K
Site 74
S691
L
K
K
N
N
R
D
S
A
V
A
S
E
Y
E
Site 75
S695
N
R
D
S
A
V
A
S
E
Y
E
L
V
Q
L
Site 76
T710
L
P
G
E
R
E
L
T
I
P
A
S
A
N
V
Site 77
Y719
P
A
S
A
N
V
F
Y
A
M
D
G
A
S
H
Site 78
S736
L
L
R
Q
R
R
R
S
S
T
A
T
P
G
V
Site 79
S737
L
R
Q
R
R
R
S
S
T
A
T
P
G
V
T
Site 80
T738
R
Q
R
R
R
S
S
T
A
T
P
G
V
T
S
Site 81
T740
R
R
R
S
S
T
A
T
P
G
V
T
S
G
P
Site 82
T744
S
T
A
T
P
G
V
T
S
G
P
S
A
S
G
Site 83
S748
P
G
V
T
S
G
P
S
A
S
G
T
P
P
S
Site 84
S750
V
T
S
G
P
S
A
S
G
T
P
P
S
E
G
Site 85
T752
S
G
P
S
A
S
G
T
P
P
S
E
G
G
G
Site 86
S755
S
A
S
G
T
P
P
S
E
G
G
G
G
S
F
Site 87
S761
P
S
E
G
G
G
G
S
F
P
R
I
K
A
T
Site 88
T768
S
F
P
R
I
K
A
T
G
R
K
I
A
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation