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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VILL
Full Name:
Villin-like protein
Alias:
Vill; Vill protein; Villin-like
Type:
Actin cytoskeleton protein
Mass (Da):
95907
Number AA:
856
UniProt ID:
O15195
International Prot ID:
IPI00289639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y41
N
F
F
E
E
H
C
Y
V
I
L
H
V
P
Q
Site 2
S49
V
I
L
H
V
P
Q
S
P
K
A
T
Q
G
A
Site 3
T53
V
P
Q
S
P
K
A
T
Q
G
A
S
S
D
L
Site 4
S58
K
A
T
Q
G
A
S
S
D
L
H
Y
W
V
G
Site 5
Y62
G
A
S
S
D
L
H
Y
W
V
G
K
Q
A
G
Site 6
Y108
E
S
D
C
F
C
S
Y
F
R
P
G
I
I
Y
Site 7
Y115
Y
F
R
P
G
I
I
Y
R
K
G
G
L
A
S
Site 8
S122
Y
R
K
G
G
L
A
S
D
L
K
H
V
E
T
Site 9
S147
I
K
G
R
K
H
V
S
A
T
E
V
E
L
S
Site 10
T149
G
R
K
H
V
S
A
T
E
V
E
L
S
W
N
Site 11
S154
S
A
T
E
V
E
L
S
W
N
S
F
N
K
G
Site 12
S157
E
V
E
L
S
W
N
S
F
N
K
G
D
I
F
Site 13
T180
I
Q
W
N
G
P
K
T
S
I
S
E
K
A
R
Site 14
S181
Q
W
N
G
P
K
T
S
I
S
E
K
A
R
G
Site 15
S183
N
G
P
K
T
S
I
S
E
K
A
R
G
L
A
Site 16
T192
K
A
R
G
L
A
L
T
Y
S
L
R
D
R
E
Site 17
S194
R
G
L
A
L
T
Y
S
L
R
D
R
E
R
G
Site 18
S233
V
L
G
R
R
V
G
S
L
R
A
A
T
P
S
Site 19
T238
V
G
S
L
R
A
A
T
P
S
K
D
I
N
Q
Site 20
S240
S
L
R
A
A
T
P
S
K
D
I
N
Q
L
Q
Site 21
Y254
Q
K
A
N
V
R
L
Y
H
V
Y
E
K
G
K
Site 22
Y257
N
V
R
L
Y
H
V
Y
E
K
G
K
D
L
V
Site 23
Y284
L
L
Q
E
E
D
F
Y
I
L
D
Q
G
G
F
Site 24
Y294
D
Q
G
G
F
K
I
Y
V
W
Q
G
R
M
S
Site 25
S301
Y
V
W
Q
G
R
M
S
S
L
Q
E
R
K
A
Site 26
S302
V
W
Q
G
R
M
S
S
L
Q
E
R
K
A
A
Site 27
S311
Q
E
R
K
A
A
F
S
R
A
V
G
F
I
Q
Site 28
Y322
G
F
I
Q
A
K
G
Y
P
T
Y
T
N
V
E
Site 29
Y325
Q
A
K
G
Y
P
T
Y
T
N
V
E
V
V
N
Site 30
T326
A
K
G
Y
P
T
Y
T
N
V
E
V
V
N
D
Site 31
S337
V
V
N
D
G
A
E
S
A
A
F
K
Q
L
F
Site 32
S348
K
Q
L
F
R
T
W
S
E
K
R
R
R
N
Q
Site 33
S363
K
L
G
G
R
D
K
S
I
H
V
K
L
D
V
Site 34
Y424
G
N
C
Y
L
V
L
Y
T
Y
Q
R
L
G
R
Site 35
Y434
Q
R
L
G
R
V
Q
Y
I
L
Y
L
W
Q
G
Site 36
Y437
G
R
V
Q
Y
I
L
Y
L
W
Q
G
H
Q
A
Site 37
S454
D
E
I
E
A
L
N
S
N
A
E
E
L
D
V
Site 38
S476
Q
E
H
V
T
M
G
S
E
P
P
H
F
L
A
Site 39
S504
G
H
H
G
K
G
Q
S
A
S
T
T
R
L
F
Site 40
S506
H
G
K
G
Q
S
A
S
T
T
R
L
F
Q
V
Site 41
T508
K
G
Q
S
A
S
T
T
R
L
F
Q
V
Q
G
Site 42
S531
M
E
V
P
A
R
A
S
S
L
N
S
S
D
I
Site 43
S532
E
V
P
A
R
A
S
S
L
N
S
S
D
I
F
Site 44
Y548
L
V
T
A
S
V
C
Y
L
W
F
G
K
G
C
Site 45
T577
I
S
R
K
N
E
E
T
V
L
E
G
Q
E
P
Site 46
Y597
A
L
G
G
R
A
P
Y
P
S
N
K
R
L
P
Site 47
S599
G
G
R
A
P
Y
P
S
N
K
R
L
P
E
E
Site 48
S609
R
L
P
E
E
V
P
S
F
Q
P
R
L
F
E
Site 49
S633
L
A
E
V
G
F
F
S
Q
E
D
L
D
K
Y
Site 50
Y640
S
Q
E
D
L
D
K
Y
D
I
M
L
L
D
T
Site 51
Y672
A
V
A
W
G
Q
E
Y
L
K
T
H
P
A
G
Site 52
T675
W
G
Q
E
Y
L
K
T
H
P
A
G
R
S
P
Site 53
S681
K
T
H
P
A
G
R
S
P
A
T
P
I
V
L
Site 54
S723
H
K
E
V
V
D
G
S
P
A
A
A
S
T
I
Site 55
S743
E
V
N
N
L
R
L
S
R
W
P
G
N
G
R
Site 56
S762
A
L
Q
A
L
K
G
S
Q
D
S
S
E
N
D
Site 57
S766
L
K
G
S
Q
D
S
S
E
N
D
L
V
R
S
Site 58
S773
S
E
N
D
L
V
R
S
P
K
S
A
G
S
R
Site 59
S776
D
L
V
R
S
P
K
S
A
G
S
R
T
S
S
Site 60
S779
R
S
P
K
S
A
G
S
R
T
S
S
S
V
S
Site 61
T781
P
K
S
A
G
S
R
T
S
S
S
V
S
S
T
Site 62
S782
K
S
A
G
S
R
T
S
S
S
V
S
S
T
S
Site 63
S783
S
A
G
S
R
T
S
S
S
V
S
S
T
S
A
Site 64
S784
A
G
S
R
T
S
S
S
V
S
S
T
S
A
T
Site 65
S786
S
R
T
S
S
S
V
S
S
T
S
A
T
I
N
Site 66
S787
R
T
S
S
S
V
S
S
T
S
A
T
I
N
G
Site 67
T788
T
S
S
S
V
S
S
T
S
A
T
I
N
G
G
Site 68
S789
S
S
S
V
S
S
T
S
A
T
I
N
G
G
L
Site 69
T791
S
V
S
S
T
S
A
T
I
N
G
G
L
R
R
Site 70
Y821
D
P
A
R
R
E
F
Y
L
S
D
S
D
F
Q
Site 71
S823
A
R
R
E
F
Y
L
S
D
S
D
F
Q
D
I
Site 72
S825
R
E
F
Y
L
S
D
S
D
F
Q
D
I
F
G
Site 73
Y839
G
K
S
K
E
E
F
Y
S
M
A
T
W
R
Q
Site 74
S840
K
S
K
E
E
F
Y
S
M
A
T
W
R
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation