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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM24
Full Name:
Transcription intermediary factor 1-alpha
Alias:
HTIF1; Kinase TIF1-alpha; RNF82; TIF1; Tif1; TIF1A; Tif1a; Transcription intermediary factor 1-alpha; Transcriptional intermediary factor 1 (PTC6,TIF1A); Transcriptional intermediary factor 1 (PTC6;TIF1A); Trim24; Tripartite motif protein 24; Tripartite motif-containing 24
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Protein kinase, atypical; ATYPICAL group; TIF1 family
Mass (Da):
116831
Number AA:
1050
UniProt ID:
O15164
International Prot ID:
IPI00005184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
A
A
A
S
G
G
P
S
A
A
P
S
G
E
N
Site 2
S28
G
G
P
S
A
A
P
S
G
E
N
E
A
E
S
Site 3
S41
E
S
R
Q
G
P
D
S
E
R
G
G
E
A
A
Site 4
T101
P
M
L
G
S
A
E
T
P
P
P
V
P
A
P
Site 5
S110
P
P
V
P
A
P
G
S
P
V
S
G
S
S
P
Site 6
S113
P
A
P
G
S
P
V
S
G
S
S
P
F
A
T
Site 7
S115
P
G
S
P
V
S
G
S
S
P
F
A
T
Q
V
Site 8
S116
G
S
P
V
S
G
S
S
P
F
A
T
Q
V
G
Site 9
T148
D
N
F
F
V
K
D
T
T
E
V
P
S
S
T
Site 10
T149
N
F
F
V
K
D
T
T
E
V
P
S
S
T
V
Site 11
S153
K
D
T
T
E
V
P
S
S
T
V
E
K
S
N
Site 12
S154
D
T
T
E
V
P
S
S
T
V
E
K
S
N
Q
Site 13
T155
T
T
E
V
P
S
S
T
V
E
K
S
N
Q
V
Site 14
S159
P
S
S
T
V
E
K
S
N
Q
V
C
T
S
C
Site 15
T201
V
K
F
T
K
D
H
T
V
R
Q
K
E
E
V
Site 16
S209
V
R
Q
K
E
E
V
S
P
E
A
V
G
V
T
Site 17
Y234
K
K
E
Q
L
K
L
Y
C
E
T
C
D
K
L
Site 18
Y256
L
E
H
K
E
H
R
Y
Q
F
I
E
E
A
F
Site 19
Y283
K
L
M
E
K
T
K
Y
I
K
F
T
G
N
Q
Site 20
S333
A
L
L
H
Q
L
E
S
L
A
K
D
H
R
M
Site 21
S368
H
F
S
K
W
A
V
S
S
G
S
S
T
A
L
Site 22
S371
K
W
A
V
S
S
G
S
S
T
A
L
L
Y
S
Site 23
S372
W
A
V
S
S
G
S
S
T
A
L
L
Y
S
K
Site 24
T373
A
V
S
S
G
S
S
T
A
L
L
Y
S
K
R
Site 25
Y377
G
S
S
T
A
L
L
Y
S
K
R
L
I
T
Y
Site 26
S378
S
S
T
A
L
L
Y
S
K
R
L
I
T
Y
R
Site 27
T383
L
Y
S
K
R
L
I
T
Y
R
L
R
H
L
L
Site 28
S397
L
R
A
R
C
D
A
S
P
V
T
N
N
T
I
Site 29
S430
L
V
I
E
D
K
E
S
Q
P
Q
M
P
K
Q
Site 30
S445
N
P
V
V
E
Q
N
S
Q
P
P
S
G
L
S
Site 31
S449
E
Q
N
S
Q
P
P
S
G
L
S
S
N
Q
L
Site 32
S452
S
Q
P
P
S
G
L
S
S
N
Q
L
S
K
F
Site 33
S453
Q
P
P
S
G
L
S
S
N
Q
L
S
K
F
P
Site 34
S457
G
L
S
S
N
Q
L
S
K
F
P
T
Q
I
S
Site 35
T461
N
Q
L
S
K
F
P
T
Q
I
S
L
A
Q
L
Site 36
S464
S
K
F
P
T
Q
I
S
L
A
Q
L
R
L
Q
Site 37
S506
Q
G
P
I
Q
Q
P
S
I
S
H
Q
Q
P
P
Site 38
S508
P
I
Q
Q
P
S
I
S
H
Q
Q
P
P
P
R
Site 39
S523
L
I
N
F
Q
N
H
S
P
K
P
N
G
P
V
Site 40
Y540
P
H
P
Q
Q
L
R
Y
P
P
N
Q
N
I
P
Site 41
S573
I
K
Q
W
Q
I
S
S
G
Q
G
T
P
S
T
Site 42
T577
Q
I
S
S
G
Q
G
T
P
S
T
T
N
S
T
Site 43
S579
S
S
G
Q
G
T
P
S
T
T
N
S
T
S
S
Site 44
T580
S
G
Q
G
T
P
S
T
T
N
S
T
S
S
T
Site 45
T581
G
Q
G
T
P
S
T
T
N
S
T
S
S
T
P
Site 46
S583
G
T
P
S
T
T
N
S
T
S
S
T
P
S
S
Site 47
S585
P
S
T
T
N
S
T
S
S
T
P
S
S
P
T
Site 48
S586
S
T
T
N
S
T
S
S
T
P
S
S
P
T
I
Site 49
T587
T
T
N
S
T
S
S
T
P
S
S
P
T
I
T
Site 50
S589
N
S
T
S
S
T
P
S
S
P
T
I
T
S
A
Site 51
S590
S
T
S
S
T
P
S
S
P
T
I
T
S
A
A
Site 52
T594
T
P
S
S
P
T
I
T
S
A
A
G
Y
D
G
Site 53
S595
P
S
S
P
T
I
T
S
A
A
G
Y
D
G
K
Site 54
Y599
T
I
T
S
A
A
G
Y
D
G
K
A
F
G
S
Site 55
S606
Y
D
G
K
A
F
G
S
P
M
I
D
L
S
S
Site 56
S612
G
S
P
M
I
D
L
S
S
P
V
G
G
S
Y
Site 57
S613
S
P
M
I
D
L
S
S
P
V
G
G
S
Y
N
Site 58
S618
L
S
S
P
V
G
G
S
Y
N
L
P
S
L
P
Site 59
Y619
S
S
P
V
G
G
S
Y
N
L
P
S
L
P
D
Site 60
S623
G
G
S
Y
N
L
P
S
L
P
D
I
D
C
S
Site 61
S630
S
L
P
D
I
D
C
S
S
T
I
M
L
D
N
Site 62
T643
D
N
I
V
R
K
D
T
N
I
D
H
G
Q
P
Site 63
S654
H
G
Q
P
R
P
P
S
N
R
T
V
Q
S
P
Site 64
T657
P
R
P
P
S
N
R
T
V
Q
S
P
N
S
S
Site 65
S660
P
S
N
R
T
V
Q
S
P
N
S
S
V
P
S
Site 66
S663
R
T
V
Q
S
P
N
S
S
V
P
S
P
G
L
Site 67
S664
T
V
Q
S
P
N
S
S
V
P
S
P
G
L
A
Site 68
S667
S
P
N
S
S
V
P
S
P
G
L
A
G
P
V
Site 69
S678
A
G
P
V
T
M
T
S
V
H
P
P
I
R
S
Site 70
S685
S
V
H
P
P
I
R
S
P
S
A
S
S
V
G
Site 71
S687
H
P
P
I
R
S
P
S
A
S
S
V
G
S
R
Site 72
S689
P
I
R
S
P
S
A
S
S
V
G
S
R
G
S
Site 73
S690
I
R
S
P
S
A
S
S
V
G
S
R
G
S
S
Site 74
S693
P
S
A
S
S
V
G
S
R
G
S
S
G
S
S
Site 75
S696
S
S
V
G
S
R
G
S
S
G
S
S
S
K
P
Site 76
S697
S
V
G
S
R
G
S
S
G
S
S
S
K
P
A
Site 77
S699
G
S
R
G
S
S
G
S
S
S
K
P
A
G
A
Site 78
S700
S
R
G
S
S
G
S
S
S
K
P
A
G
A
D
Site 79
S701
R
G
S
S
G
S
S
S
K
P
A
G
A
D
S
Site 80
S708
S
K
P
A
G
A
D
S
T
H
K
V
P
V
V
Site 81
Y733
N
S
G
P
P
E
N
Y
D
F
P
V
V
I
V
Site 82
S744
V
V
I
V
K
Q
E
S
D
E
E
S
R
P
Q
Site 83
S748
K
Q
E
S
D
E
E
S
R
P
Q
N
A
N
Y
Site 84
Y755
S
R
P
Q
N
A
N
Y
P
R
S
I
L
T
S
Site 85
S758
Q
N
A
N
Y
P
R
S
I
L
T
S
L
L
L
Site 86
S762
Y
P
R
S
I
L
T
S
L
L
L
N
S
S
Q
Site 87
S767
L
T
S
L
L
L
N
S
S
Q
S
S
T
S
E
Site 88
S768
T
S
L
L
L
N
S
S
Q
S
S
T
S
E
E
Site 89
S770
L
L
L
N
S
S
Q
S
S
T
S
E
E
T
V
Site 90
S771
L
L
N
S
S
Q
S
S
T
S
E
E
T
V
L
Site 91
T772
L
N
S
S
Q
S
S
T
S
E
E
T
V
L
R
Site 92
S773
N
S
S
Q
S
S
T
S
E
E
T
V
L
R
S
Site 93
T776
Q
S
S
T
S
E
E
T
V
L
R
S
D
A
P
Site 94
S780
S
E
E
T
V
L
R
S
D
A
P
D
S
T
G
Site 95
S785
L
R
S
D
A
P
D
S
T
G
D
Q
P
G
L
Site 96
T786
R
S
D
A
P
D
S
T
G
D
Q
P
G
L
H
Site 97
S797
P
G
L
H
Q
D
N
S
S
N
G
K
S
E
W
Site 98
S798
G
L
H
Q
D
N
S
S
N
G
K
S
E
W
L
Site 99
S802
D
N
S
S
N
G
K
S
E
W
L
D
P
S
Q
Site 100
S808
K
S
E
W
L
D
P
S
Q
K
S
P
L
H
V
Site 101
S811
W
L
D
P
S
Q
K
S
P
L
H
V
G
E
T
Site 102
T818
S
P
L
H
V
G
E
T
R
K
E
D
D
P
N
Site 103
T856
H
L
S
C
H
V
P
T
L
T
N
F
P
S
G
Site 104
T858
S
C
H
V
P
T
L
T
N
F
P
S
G
E
W
Site 105
S874
C
T
F
C
R
D
L
S
K
P
E
V
E
Y
D
Site 106
Y880
L
S
K
P
E
V
E
Y
D
C
D
A
P
S
H
Site 107
S886
E
Y
D
C
D
A
P
S
H
N
S
E
K
K
K
Site 108
T894
H
N
S
E
K
K
K
T
E
G
L
V
K
L
T
Site 109
T901
T
E
G
L
V
K
L
T
P
I
D
K
R
K
C
Site 110
Y916
E
R
L
L
L
F
L
Y
C
H
E
M
S
L
A
Site 111
T931
F
Q
D
P
V
P
L
T
V
P
D
Y
Y
K
I
Site 112
Y935
V
P
L
T
V
P
D
Y
Y
K
I
I
K
N
P
Site 113
Y936
P
L
T
V
P
D
Y
Y
K
I
I
K
N
P
M
Site 114
S946
I
K
N
P
M
D
L
S
T
I
K
K
R
L
Q
Site 115
T947
K
N
P
M
D
L
S
T
I
K
K
R
L
Q
E
Site 116
Y956
K
K
R
L
Q
E
D
Y
S
M
Y
S
K
P
E
Site 117
S957
K
R
L
Q
E
D
Y
S
M
Y
S
K
P
E
D
Site 118
Y959
L
Q
E
D
Y
S
M
Y
S
K
P
E
D
F
V
Site 119
S984
A
E
F
N
E
P
D
S
E
V
A
N
A
G
I
Site 120
Y996
A
G
I
K
L
E
N
Y
F
E
E
L
L
K
N
Site 121
Y1005
E
E
L
L
K
N
L
Y
P
E
K
R
F
P
K
Site 122
S1025
E
S
E
D
N
K
F
S
D
D
S
D
D
D
F
Site 123
S1028
D
N
K
F
S
D
D
S
D
D
D
F
V
Q
P
Site 124
S1042
P
R
K
K
R
L
K
S
I
E
E
R
Q
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation