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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANGPT2
Full Name:
Angiopoietin-2
Alias:
AGPT2; ANG2; ANG-2; ANGP2; Tie2-ligand
Type:
Uncharacterized protein
Mass (Da):
56919
Number AA:
496
UniProt ID:
O15123
International Prot ID:
IPI00005128
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0030154
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
Y
N
N
F
R
K
S
M
D
S
I
G
K
K
Site 2
S28
N
F
R
K
S
M
D
S
I
G
K
K
Q
Y
Q
Site 3
Y34
D
S
I
G
K
K
Q
Y
Q
V
Q
H
G
S
C
Site 4
S42
Q
V
Q
H
G
S
C
S
Y
T
F
L
L
P
E
Site 5
T44
Q
H
G
S
C
S
Y
T
F
L
L
P
E
M
D
Site 6
S55
P
E
M
D
N
C
R
S
S
S
S
P
Y
V
S
Site 7
S56
E
M
D
N
C
R
S
S
S
S
P
Y
V
S
N
Site 8
S57
M
D
N
C
R
S
S
S
S
P
Y
V
S
N
A
Site 9
S58
D
N
C
R
S
S
S
S
P
Y
V
S
N
A
V
Site 10
Y60
C
R
S
S
S
S
P
Y
V
S
N
A
V
Q
R
Site 11
S62
S
S
S
S
P
Y
V
S
N
A
V
Q
R
D
A
Site 12
S76
A
P
L
E
Y
D
D
S
V
Q
R
L
Q
V
L
Site 13
T143
A
E
Q
T
R
K
L
T
D
V
E
A
Q
V
L
Site 14
S164
E
L
Q
L
L
E
H
S
L
S
T
N
K
L
E
Site 15
S166
Q
L
L
E
H
S
L
S
T
N
K
L
E
K
Q
Site 16
T178
E
K
Q
I
L
D
Q
T
S
E
I
N
K
L
Q
Site 17
S179
K
Q
I
L
D
Q
T
S
E
I
N
K
L
Q
D
Site 18
S189
N
K
L
Q
D
K
N
S
F
L
E
K
K
V
L
Site 19
S221
D
Q
L
Q
V
L
V
S
K
Q
N
S
I
I
E
Site 20
S225
V
L
V
S
K
Q
N
S
I
I
E
E
L
E
K
Site 21
T238
E
K
K
I
V
T
A
T
V
N
N
S
V
L
Q
Site 22
T254
Q
Q
H
D
L
M
E
T
V
N
N
L
L
T
M
Site 23
T260
E
T
V
N
N
L
L
T
M
M
S
T
S
N
S
Site 24
S263
N
N
L
L
T
M
M
S
T
S
N
S
A
K
D
Site 25
S265
L
L
T
M
M
S
T
S
N
S
A
K
D
P
T
Site 26
S267
T
M
M
S
T
S
N
S
A
K
D
P
T
V
A
Site 27
T272
S
N
S
A
K
D
P
T
V
A
K
E
E
Q
I
Site 28
S280
V
A
K
E
E
Q
I
S
F
R
D
C
A
E
V
Site 29
T294
V
F
K
S
G
H
T
T
N
G
I
Y
T
L
T
Site 30
Y298
G
H
T
T
N
G
I
Y
T
L
T
F
P
N
S
Site 31
T301
T
N
G
I
Y
T
L
T
F
P
N
S
T
E
E
Site 32
S305
Y
T
L
T
F
P
N
S
T
E
E
I
K
A
Y
Site 33
Y312
S
T
E
E
I
K
A
Y
C
D
M
E
A
G
G
Site 34
S332
I
Q
R
R
E
D
G
S
V
D
F
Q
R
T
W
Site 35
Y342
F
Q
R
T
W
K
E
Y
K
V
G
F
G
N
P
Site 36
Y353
F
G
N
P
S
G
E
Y
W
L
G
N
E
F
V
Site 37
Y369
Q
L
T
N
Q
Q
R
Y
V
L
K
I
H
L
K
Site 38
Y387
G
N
E
A
Y
S
L
Y
E
H
F
Y
L
S
S
Site 39
Y391
Y
S
L
Y
E
H
F
Y
L
S
S
E
E
L
N
Site 40
S393
L
Y
E
H
F
Y
L
S
S
E
E
L
N
Y
R
Site 41
Y399
L
S
S
E
E
L
N
Y
R
I
H
L
K
G
L
Site 42
S414
T
G
T
A
G
K
I
S
S
I
S
Q
P
G
N
Site 43
S415
G
T
A
G
K
I
S
S
I
S
Q
P
G
N
D
Site 44
S417
A
G
K
I
S
S
I
S
Q
P
G
N
D
F
S
Site 45
S424
S
Q
P
G
N
D
F
S
T
K
D
G
D
N
D
Site 46
Y459
P
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
Site 47
Y460
S
N
L
N
G
M
Y
Y
P
Q
R
Q
N
T
N
Site 48
Y482
Y
Y
W
K
G
S
G
Y
S
L
K
A
T
T
M
Site 49
T487
S
G
Y
S
L
K
A
T
T
M
M
I
R
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation