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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FYB
Full Name:
FYN-binding protein
Alias:
Adhesion and degranulation promoting adaptor protein; FYB-120/130; FYN binding protein; FYN-T-binding protein; P120/p130; SLAP130; SLP-76 associated phosphoprotein; SLP-76-associated phosphoprotein
Type:
Adapter/scaffold protein
Mass (Da):
85387
Number AA:
783
UniProt ID:
O15117
International Prot ID:
IPI00446986
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0006955
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
A
K
Y
N
T
G
G
N
P
T
Site 2
S15
G
N
P
T
E
D
V
S
V
N
S
R
P
F
R
Site 3
T24
N
S
R
P
F
R
V
T
G
P
N
S
S
S
G
Site 4
S28
F
R
V
T
G
P
N
S
S
S
G
I
Q
A
R
Site 5
S46
F
N
N
Q
G
N
A
S
P
P
A
G
P
S
N
Site 6
S52
A
S
P
P
A
G
P
S
N
V
P
K
F
G
S
Site 7
S59
S
N
V
P
K
F
G
S
P
K
P
P
V
A
V
Site 8
S69
P
P
V
A
V
K
P
S
S
E
E
K
P
D
K
Site 9
S70
P
V
A
V
K
P
S
S
E
E
K
P
D
K
E
Site 10
T86
K
P
P
F
L
K
P
T
G
A
G
Q
R
F
G
Site 11
T94
G
A
G
Q
R
F
G
T
P
A
S
L
T
T
R
Site 12
S97
Q
R
F
G
T
P
A
S
L
T
T
R
D
P
E
Site 13
T99
F
G
T
P
A
S
L
T
T
R
D
P
E
A
K
Site 14
T128
P
K
E
D
S
K
P
T
F
P
W
P
P
G
N
Site 15
S138
W
P
P
G
N
K
P
S
L
H
S
V
N
Q
D
Site 16
S155
L
K
P
L
G
P
K
S
G
P
T
P
P
T
S
Site 17
T158
L
G
P
K
S
G
P
T
P
P
T
S
E
N
E
Site 18
T161
K
S
G
P
T
P
P
T
S
E
N
E
Q
K
Q
Site 19
S162
S
G
P
T
P
P
T
S
E
N
E
Q
K
Q
A
Site 20
S182
G
V
K
G
K
F
M
S
A
S
Q
D
L
E
P
Site 21
S184
K
G
K
F
M
S
A
S
Q
D
L
E
P
K
P
Site 22
S205
F
G
Q
K
P
P
L
S
T
E
N
S
H
E
D
Site 23
T206
G
Q
K
P
P
L
S
T
E
N
S
H
E
D
E
Site 24
S209
P
P
L
S
T
E
N
S
H
E
D
E
S
P
M
Site 25
S214
E
N
S
H
E
D
E
S
P
M
K
N
V
S
S
Site 26
S220
E
S
P
M
K
N
V
S
S
S
K
G
S
P
A
Site 27
S221
S
P
M
K
N
V
S
S
S
K
G
S
P
A
P
Site 28
S222
P
M
K
N
V
S
S
S
K
G
S
P
A
P
L
Site 29
S225
N
V
S
S
S
K
G
S
P
A
P
L
G
V
R
Site 30
S233
P
A
P
L
G
V
R
S
K
S
G
P
L
K
P
Site 31
S235
P
L
G
V
R
S
K
S
G
P
L
K
P
A
R
Site 32
S245
L
K
P
A
R
E
D
S
E
N
K
D
H
A
G
Site 33
S255
K
D
H
A
G
E
I
S
S
L
P
F
P
G
V
Site 34
S269
V
V
L
K
P
A
A
S
R
G
G
P
G
V
S
Site 35
S276
S
R
G
G
P
G
V
S
K
N
G
E
E
K
K
Site 36
T294
K
I
D
A
A
K
N
T
F
Q
S
K
I
N
Q
Site 37
S306
I
N
Q
E
E
L
A
S
G
T
P
P
A
R
F
Site 38
T308
Q
E
E
L
A
S
G
T
P
P
A
R
F
P
K
Site 39
S318
A
R
F
P
K
A
P
S
K
L
T
V
G
G
P
Site 40
T321
P
K
A
P
S
K
L
T
V
G
G
P
W
G
Q
Site 41
S329
V
G
G
P
W
G
Q
S
Q
E
K
E
K
G
D
Site 42
S339
K
E
K
G
D
K
N
S
A
T
P
K
Q
K
P
Site 43
T341
K
G
D
K
N
S
A
T
P
K
Q
K
P
L
P
Site 44
T352
K
P
L
P
P
L
F
T
L
G
P
P
P
P
K
Site 45
T369
R
P
P
N
V
D
L
T
K
F
H
K
T
S
S
Site 46
T374
D
L
T
K
F
H
K
T
S
S
G
N
S
T
S
Site 47
S375
L
T
K
F
H
K
T
S
S
G
N
S
T
S
K
Site 48
S376
T
K
F
H
K
T
S
S
G
N
S
T
S
K
G
Site 49
S379
H
K
T
S
S
G
N
S
T
S
K
G
Q
T
S
Site 50
T380
K
T
S
S
G
N
S
T
S
K
G
Q
T
S
Y
Site 51
S381
T
S
S
G
N
S
T
S
K
G
Q
T
S
Y
S
Site 52
T385
N
S
T
S
K
G
Q
T
S
Y
S
T
T
S
L
Site 53
S386
S
T
S
K
G
Q
T
S
Y
S
T
T
S
L
P
Site 54
Y387
T
S
K
G
Q
T
S
Y
S
T
T
S
L
P
P
Site 55
S388
S
K
G
Q
T
S
Y
S
T
T
S
L
P
P
P
Site 56
T390
G
Q
T
S
Y
S
T
T
S
L
P
P
P
P
P
Site 57
S391
Q
T
S
Y
S
T
T
S
L
P
P
P
P
P
S
Site 58
S398
S
L
P
P
P
P
P
S
H
P
A
S
Q
P
P
Site 59
S402
P
P
P
S
H
P
A
S
Q
P
P
L
P
A
S
Site 60
S409
S
Q
P
P
L
P
A
S
H
P
S
Q
P
P
V
Site 61
S412
P
L
P
A
S
H
P
S
Q
P
P
V
P
S
L
Site 62
S418
P
S
Q
P
P
V
P
S
L
P
P
R
N
I
K
Site 63
S432
K
P
P
F
D
L
K
S
P
V
N
E
D
N
Q
Site 64
T443
E
D
N
Q
D
G
V
T
H
S
D
G
A
G
N
Site 65
S445
N
Q
D
G
V
T
H
S
D
G
A
G
N
L
D
Site 66
S457
N
L
D
E
E
Q
D
S
E
G
E
T
Y
E
D
Site 67
T461
E
Q
D
S
E
G
E
T
Y
E
D
I
E
A
S
Site 68
Y462
Q
D
S
E
G
E
T
Y
E
D
I
E
A
S
K
Site 69
S468
T
Y
E
D
I
E
A
S
K
E
R
E
K
K
R
Site 70
T507
I
K
K
K
F
K
L
T
G
P
I
Q
V
I
H
Site 71
S530
K
G
G
K
N
E
L
S
F
K
Q
G
E
Q
I
Site 72
T543
Q
I
E
I
I
R
I
T
D
N
P
E
G
K
W
Site 73
T554
E
G
K
W
L
G
R
T
A
R
G
S
Y
G
Y
Site 74
S558
L
G
R
T
A
R
G
S
Y
G
Y
I
K
T
T
Site 75
Y559
G
R
T
A
R
G
S
Y
G
Y
I
K
T
T
A
Site 76
T564
G
S
Y
G
Y
I
K
T
T
A
V
E
I
D
Y
Site 77
Y571
T
T
A
V
E
I
D
Y
D
S
L
K
L
K
K
Site 78
S573
A
V
E
I
D
Y
D
S
L
K
L
K
K
D
S
Site 79
S580
S
L
K
L
K
K
D
S
L
G
A
P
S
R
P
Site 80
Y595
I
E
D
D
Q
E
V
Y
D
D
V
A
E
Q
D
Site 81
S605
V
A
E
Q
D
D
I
S
S
H
S
Q
S
G
S
Site 82
S606
A
E
Q
D
D
I
S
S
H
S
Q
S
G
S
G
Site 83
S608
Q
D
D
I
S
S
H
S
Q
S
G
S
G
G
I
Site 84
S610
D
I
S
S
H
S
Q
S
G
S
G
G
I
F
P
Site 85
S612
S
S
H
S
Q
S
G
S
G
G
I
F
P
P
P
Site 86
Y625
P
P
P
D
D
D
I
Y
D
G
I
E
E
E
D
Site 87
Y651
L
D
M
G
D
E
V
Y
D
D
V
D
T
S
D
Site 88
T656
E
V
Y
D
D
V
D
T
S
D
F
P
V
S
S
Site 89
S657
V
Y
D
D
V
D
T
S
D
F
P
V
S
S
A
Site 90
S662
D
T
S
D
F
P
V
S
S
A
E
M
S
Q
G
Site 91
S663
T
S
D
F
P
V
S
S
A
E
M
S
Q
G
T
Site 92
S667
P
V
S
S
A
E
M
S
Q
G
T
N
F
G
K
Site 93
Y701
D
F
R
K
K
F
K
Y
D
G
E
I
R
V
L
Site 94
Y709
D
G
E
I
R
V
L
Y
S
T
K
V
T
T
S
Site 95
T714
V
L
Y
S
T
K
V
T
T
S
I
T
S
K
K
Site 96
S716
Y
S
T
K
V
T
T
S
I
T
S
K
K
W
G
Site 97
S734
L
Q
V
K
P
G
E
S
L
E
V
I
Q
T
T
Site 98
T740
E
S
L
E
V
I
Q
T
T
D
D
T
K
V
L
Site 99
T744
V
I
Q
T
T
D
D
T
K
V
L
C
R
N
E
Site 100
Y755
C
R
N
E
E
G
K
Y
G
Y
V
L
R
S
Y
Site 101
Y757
N
E
E
G
K
Y
G
Y
V
L
R
S
Y
L
A
Site 102
Y762
Y
G
Y
V
L
R
S
Y
L
A
D
N
D
G
E
Site 103
Y771
A
D
N
D
G
E
I
Y
D
D
I
A
D
G
C
Site 104
Y780
D
I
A
D
G
C
I
Y
D
N
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation