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Updated November 2019
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Protein Info
Short Name:
ARHGEF11
Full Name:
Rho guanine nucleotide exchange factor 11
Alias:
ARHGB; Glutamate transporter EAAT4-associated protein 48; GTRAP48; KIAA0380; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
167704
Number AA:
1522
UniProt ID:
O15085
International Prot ID:
IPI00157442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0001664
GO:0005096
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007266
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
V
R
L
P
Q
S
I
D
R
L
S
S
L
Site 2
S13
P
Q
S
I
D
R
L
S
S
L
S
S
L
G
D
Site 3
S14
Q
S
I
D
R
L
S
S
L
S
S
L
G
D
S
Site 4
S16
I
D
R
L
S
S
L
S
S
L
G
D
S
A
P
Site 5
S17
D
R
L
S
S
L
S
S
L
G
D
S
A
P
E
Site 6
S21
S
L
S
S
L
G
D
S
A
P
E
R
K
S
P
Site 7
S27
D
S
A
P
E
R
K
S
P
S
H
H
R
Q
P
Site 8
S29
A
P
E
R
K
S
P
S
H
H
R
Q
P
S
D
Site 9
S35
P
S
H
H
R
Q
P
S
D
A
S
E
T
T
G
Site 10
S38
H
R
Q
P
S
D
A
S
E
T
T
G
L
V
Q
Site 11
T40
Q
P
S
D
A
S
E
T
T
G
L
V
Q
R
C
Site 12
T60
D
Q
H
G
F
G
F
T
V
S
G
D
R
I
V
Site 13
S130
S
P
S
S
M
G
I
S
G
L
Q
Q
D
P
S
Site 14
S137
S
G
L
Q
Q
D
P
S
P
A
G
A
P
R
I
Site 15
T145
P
A
G
A
P
R
I
T
S
V
I
P
S
P
P
Site 16
S146
A
G
A
P
R
I
T
S
V
I
P
S
P
P
P
Site 17
S150
R
I
T
S
V
I
P
S
P
P
P
P
P
P
L
Site 18
T164
L
P
P
P
Q
R
I
T
G
P
K
P
L
Q
D
Site 19
Y200
L
Q
D
I
L
P
L
Y
G
D
T
S
Q
R
P
Site 20
S204
L
P
L
Y
G
D
T
S
Q
R
P
S
E
G
R
Site 21
S208
G
D
T
S
Q
R
P
S
E
G
R
L
S
L
D
Site 22
S213
R
P
S
E
G
R
L
S
L
D
S
Q
E
G
D
Site 23
S216
E
G
R
L
S
L
D
S
Q
E
G
D
S
G
L
Site 24
S221
L
D
S
Q
E
G
D
S
G
L
D
S
G
T
E
Site 25
S225
E
G
D
S
G
L
D
S
G
T
E
R
F
P
S
Site 26
T227
D
S
G
L
D
S
G
T
E
R
F
P
S
L
S
Site 27
S232
S
G
T
E
R
F
P
S
L
S
E
S
L
M
N
Site 28
S234
T
E
R
F
P
S
L
S
E
S
L
M
N
R
N
Site 29
S236
R
F
P
S
L
S
E
S
L
M
N
R
N
S
V
Site 30
S242
E
S
L
M
N
R
N
S
V
L
S
D
P
G
L
Site 31
S245
M
N
R
N
S
V
L
S
D
P
G
L
D
S
P
Site 32
S251
L
S
D
P
G
L
D
S
P
R
T
S
P
V
I
Site 33
T254
P
G
L
D
S
P
R
T
S
P
V
I
M
A
R
Site 34
S255
G
L
D
S
P
R
T
S
P
V
I
M
A
R
V
Site 35
S271
Q
H
H
R
R
Q
G
S
D
A
A
V
P
S
T
Site 36
S277
G
S
D
A
A
V
P
S
T
G
D
Q
G
V
D
Site 37
S286
G
D
Q
G
V
D
Q
S
P
K
P
L
I
I
G
Site 38
Y298
I
I
G
P
E
E
D
Y
D
P
G
Y
F
N
N
Site 39
Y302
E
E
D
Y
D
P
G
Y
F
N
N
E
S
D
I
Site 40
S319
Q
D
L
E
K
L
K
S
R
P
A
H
L
G
V
Site 41
Y349
F
Y
L
C
A
E
V
Y
Q
Q
A
S
P
K
D
Site 42
S353
A
E
V
Y
Q
Q
A
S
P
K
D
S
R
S
L
Site 43
S357
Q
Q
A
S
P
K
D
S
R
S
L
G
K
D
I
Site 44
S359
A
S
P
K
D
S
R
S
L
G
K
D
I
W
N
Site 45
S389
M
L
Q
A
E
I
D
S
R
L
R
N
S
E
D
Site 46
S394
I
D
S
R
L
R
N
S
E
D
A
R
G
V
L
Site 47
Y419
I
Q
E
Q
I
H
D
Y
R
T
K
R
T
L
G
Site 48
T421
E
Q
I
H
D
Y
R
T
K
R
T
L
G
L
G
Site 49
S429
K
R
T
L
G
L
G
S
L
Y
G
E
N
D
L
Site 50
Y431
T
L
G
L
G
S
L
Y
G
E
N
D
L
L
D
Site 51
S462
A
A
L
G
D
I
L
S
K
Y
E
E
D
R
S
Site 52
Y464
L
G
D
I
L
S
K
Y
E
E
D
R
S
A
P
Site 53
S469
S
K
Y
E
E
D
R
S
A
P
M
D
F
A
L
Site 54
Y479
M
D
F
A
L
N
T
Y
M
S
H
A
G
I
R
Site 55
S493
R
L
R
E
A
R
P
S
N
T
A
E
K
A
Q
Site 56
T515
W
L
P
F
F
P
K
T
K
K
S
S
N
S
K
Site 57
S518
F
F
P
K
T
K
K
S
S
N
S
K
K
E
K
Site 58
S519
F
P
K
T
K
K
S
S
N
S
K
K
E
K
D
Site 59
Y539
K
R
N
P
I
L
K
Y
I
G
K
P
K
S
S
Site 60
S545
K
Y
I
G
K
P
K
S
S
S
Q
S
T
F
H
Site 61
S547
I
G
K
P
K
S
S
S
Q
S
T
F
H
I
P
Site 62
S549
K
P
K
S
S
S
Q
S
T
F
H
I
P
L
S
Site 63
T550
P
K
S
S
S
Q
S
T
F
H
I
P
L
S
P
Site 64
S556
S
T
F
H
I
P
L
S
P
V
E
V
K
P
G
Site 65
Y578
H
F
E
N
N
Q
Q
Y
D
A
P
E
P
G
T
Site 66
T585
Y
D
A
P
E
P
G
T
Q
R
L
S
T
G
S
Site 67
S589
E
P
G
T
Q
R
L
S
T
G
S
F
P
E
D
Site 68
T590
P
G
T
Q
R
L
S
T
G
S
F
P
E
D
L
Site 69
S592
T
Q
R
L
S
T
G
S
F
P
E
D
L
L
E
Site 70
S600
F
P
E
D
L
L
E
S
D
S
S
R
S
E
I
Site 71
S602
E
D
L
L
E
S
D
S
S
R
S
E
I
R
L
Site 72
S603
D
L
L
E
S
D
S
S
R
S
E
I
R
L
G
Site 73
S605
L
E
S
D
S
S
R
S
E
I
R
L
G
R
S
Site 74
S614
I
R
L
G
R
S
E
S
L
K
G
R
E
E
M
Site 75
S633
K
A
E
N
V
P
R
S
R
S
D
V
D
M
D
Site 76
S635
E
N
V
P
R
S
R
S
D
V
D
M
D
A
A
Site 77
S651
E
A
T
R
L
H
Q
S
A
S
S
S
T
S
S
Site 78
S653
T
R
L
H
Q
S
A
S
S
S
T
S
S
L
S
Site 79
S654
R
L
H
Q
S
A
S
S
S
T
S
S
L
S
T
Site 80
S655
L
H
Q
S
A
S
S
S
T
S
S
L
S
T
R
Site 81
S657
Q
S
A
S
S
S
T
S
S
L
S
T
R
S
L
Site 82
S658
S
A
S
S
S
T
S
S
L
S
T
R
S
L
E
Site 83
S660
S
S
S
T
S
S
L
S
T
R
S
L
E
N
P
Site 84
T661
S
S
T
S
S
L
S
T
R
S
L
E
N
P
T
Site 85
S663
T
S
S
L
S
T
R
S
L
E
N
P
T
P
P
Site 86
T668
T
R
S
L
E
N
P
T
P
P
F
T
P
K
M
Site 87
T672
E
N
P
T
P
P
F
T
P
K
M
G
R
R
S
Site 88
S679
T
P
K
M
G
R
R
S
I
E
S
P
S
L
G
Site 89
S682
M
G
R
R
S
I
E
S
P
S
L
G
F
C
T
Site 90
S684
R
R
S
I
E
S
P
S
L
G
F
C
T
D
T
Site 91
S705
E
D
D
L
G
Q
L
S
D
L
E
P
E
P
D
Site 92
T729
K
D
V
V
A
G
L
T
Q
R
E
I
D
R
Q
Site 93
Y761
R
V
L
D
L
I
F
Y
Q
R
M
K
K
E
N
Site 94
T845
I
A
L
E
L
I
K
T
K
Q
R
K
E
S
R
Site 95
S851
K
T
K
Q
R
K
E
S
R
F
Q
L
F
M
Q
Site 96
S877
Q
L
R
D
L
I
I
S
E
M
Q
R
L
T
K
Site 97
T883
I
S
E
M
Q
R
L
T
K
Y
P
L
L
L
E
Site 98
Y885
E
M
Q
R
L
T
K
Y
P
L
L
L
E
S
I
Site 99
S901
K
H
T
E
G
G
T
S
E
H
E
K
L
C
R
Site 100
Y919
Q
C
R
E
I
L
K
Y
V
N
E
A
V
K
Q
Site 101
S949
A
T
A
L
E
R
A
S
N
P
L
A
A
E
F
Site 102
S958
P
L
A
A
E
F
K
S
L
D
L
T
T
R
K
Site 103
T962
E
F
K
S
L
D
L
T
T
R
K
M
I
H
E
Site 104
T973
M
I
H
E
G
P
L
T
W
R
I
S
K
D
K
Site 105
S977
G
P
L
T
W
R
I
S
K
D
K
T
L
D
L
Site 106
T981
W
R
I
S
K
D
K
T
L
D
L
H
V
L
L
Site 107
S1009
K
L
L
L
K
C
H
S
K
T
A
V
G
S
S
Site 108
T1011
L
L
K
C
H
S
K
T
A
V
G
S
S
D
S
Site 109
S1016
S
K
T
A
V
G
S
S
D
S
K
Q
T
F
S
Site 110
S1018
T
A
V
G
S
S
D
S
K
Q
T
F
S
P
V
Site 111
T1021
G
S
S
D
S
K
Q
T
F
S
P
V
L
K
L
Site 112
S1023
S
D
S
K
Q
T
F
S
P
V
L
K
L
N
A
Site 113
T1063
I
Y
E
L
V
A
L
T
S
S
D
K
N
T
W
Site 114
S1064
Y
E
L
V
A
L
T
S
S
D
K
N
T
W
M
Site 115
S1065
E
L
V
A
L
T
S
S
D
K
N
T
W
M
E
Site 116
T1069
L
T
S
S
D
K
N
T
W
M
E
L
L
E
E
Site 117
T1082
E
E
A
V
R
N
A
T
R
H
P
G
A
A
P
Site 118
T1108
E
P
A
Q
Q
G
P
T
P
S
R
V
E
L
D
Site 119
S1117
S
R
V
E
L
D
D
S
D
V
F
H
G
E
P
Site 120
S1135
E
L
P
G
G
T
G
S
Q
Q
R
V
Q
G
K
Site 121
S1155
E
D
P
E
Q
E
G
S
A
E
E
E
E
L
G
Site 122
S1168
L
G
V
L
P
C
P
S
T
S
L
D
G
E
N
Site 123
S1170
V
L
P
C
P
S
T
S
L
D
G
E
N
R
G
Site 124
T1235
Q
E
P
E
D
D
L
T
P
T
P
S
V
I
S
Site 125
T1237
P
E
D
D
L
T
P
T
P
S
V
I
S
V
T
Site 126
S1239
D
D
L
T
P
T
P
S
V
I
S
V
T
S
H
Site 127
S1242
T
P
T
P
S
V
I
S
V
T
S
H
P
W
D
Site 128
S1245
P
S
V
I
S
V
T
S
H
P
W
D
P
G
S
Site 129
S1252
S
H
P
W
D
P
G
S
P
G
Q
A
P
P
G
Site 130
T1265
P
G
G
E
G
D
N
T
Q
L
A
G
L
E
G
Site 131
S1284
Q
E
D
M
G
L
C
S
L
E
H
L
P
P
R
Site 132
S1295
L
P
P
R
T
R
N
S
G
I
W
E
S
P
E
Site 133
S1300
R
N
S
G
I
W
E
S
P
E
L
D
R
N
L
Site 134
S1312
R
N
L
A
E
D
A
S
S
T
E
A
A
G
G
Site 135
S1313
N
L
A
E
D
A
S
S
T
E
A
A
G
G
Y
Site 136
S1340
V
V
P
A
L
P
E
S
G
Q
S
E
P
G
P
Site 137
S1343
A
L
P
E
S
G
Q
S
E
P
G
P
P
E
V
Site 138
Y1362
K
A
T
G
N
C
F
Y
V
S
M
P
S
G
P
Site 139
S1364
T
G
N
C
F
Y
V
S
M
P
S
G
P
P
D
Site 140
S1367
C
F
Y
V
S
M
P
S
G
P
P
D
S
S
T
Site 141
S1372
M
P
S
G
P
P
D
S
S
T
D
H
S
E
A
Site 142
S1373
P
S
G
P
P
D
S
S
T
D
H
S
E
A
P
Site 143
T1374
S
G
P
P
D
S
S
T
D
H
S
E
A
P
M
Site 144
S1377
P
D
S
S
T
D
H
S
E
A
P
M
S
P
P
Site 145
S1382
D
H
S
E
A
P
M
S
P
P
Q
P
D
S
L
Site 146
S1388
M
S
P
P
Q
P
D
S
L
P
A
G
Q
T
E
Site 147
S1411
N
D
D
P
R
R
P
S
R
S
P
P
S
L
A
Site 148
S1413
D
P
R
R
P
S
R
S
P
P
S
L
A
L
R
Site 149
S1416
R
P
S
R
S
P
P
S
L
A
L
R
D
V
G
Site 150
S1452
A
H
R
E
L
L
K
S
L
G
G
E
S
S
G
Site 151
S1457
L
K
S
L
G
G
E
S
S
G
G
T
T
P
V
Site 152
S1458
K
S
L
G
G
E
S
S
G
G
T
T
P
V
G
Site 153
T1461
G
G
E
S
S
G
G
T
T
P
V
G
S
F
H
Site 154
T1462
G
E
S
S
G
G
T
T
P
V
G
S
F
H
T
Site 155
S1466
G
G
T
T
P
V
G
S
F
H
T
E
A
A
R
Site 156
T1475
H
T
E
A
A
R
W
T
D
G
S
L
S
P
P
Site 157
S1478
A
A
R
W
T
D
G
S
L
S
P
P
A
K
E
Site 158
S1480
R
W
T
D
G
S
L
S
P
P
A
K
E
P
L
Site 159
S1489
P
A
K
E
P
L
A
S
D
S
R
N
S
H
E
Site 160
S1491
K
E
P
L
A
S
D
S
R
N
S
H
E
L
G
Site 161
S1494
L
A
S
D
S
R
N
S
H
E
L
G
P
C
P
Site 162
S1505
G
P
C
P
E
D
G
S
D
A
P
L
E
D
S
Site 163
S1512
S
D
A
P
L
E
D
S
T
A
D
A
A
A
S
Site 164
S1519
S
T
A
D
A
A
A
S
P
G
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation