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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERC2
Full Name:
ERC protein 2
Alias:
CAST; CAST1; CAZ-associated structural protein; Cytomatrix protein p110; ELKS/RAB6-interacting/CAST family member 2; ELKSL; ERC 2; KIAA0378; SPBC110; Spc110
Type:
Cytoskeletal protein
Mass (Da):
110558
Number AA:
957
UniProt ID:
O15083
International Prot ID:
IPI00456707
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
Y
G
S
A
R
T
I
T
N
L
E
G
S
P
S
Site 2
S14
T
I
T
N
L
E
G
S
P
S
R
S
P
R
L
Site 3
S16
T
N
L
E
G
S
P
S
R
S
P
R
L
P
R
Site 4
S18
L
E
G
S
P
S
R
S
P
R
L
P
R
S
P
Site 5
S24
R
S
P
R
L
P
R
S
P
R
L
G
H
R
R
Site 6
T32
P
R
L
G
H
R
R
T
S
S
G
G
G
G
G
Site 7
S33
R
L
G
H
R
R
T
S
S
G
G
G
G
G
T
Site 8
S34
L
G
H
R
R
T
S
S
G
G
G
G
G
T
G
Site 9
T43
G
G
G
G
T
G
K
T
L
S
M
E
N
I
Q
Site 10
S45
G
G
T
G
K
T
L
S
M
E
N
I
Q
S
L
Site 11
S51
L
S
M
E
N
I
Q
S
L
N
A
A
Y
A
T
Site 12
Y56
I
Q
S
L
N
A
A
Y
A
T
S
G
P
M
Y
Site 13
S59
L
N
A
A
Y
A
T
S
G
P
M
Y
L
S
D
Site 14
Y63
Y
A
T
S
G
P
M
Y
L
S
D
H
E
G
V
Site 15
S65
T
S
G
P
M
Y
L
S
D
H
E
G
V
A
S
Site 16
S72
S
D
H
E
G
V
A
S
T
T
Y
P
K
G
T
Site 17
T73
D
H
E
G
V
A
S
T
T
Y
P
K
G
T
M
Site 18
Y75
E
G
V
A
S
T
T
Y
P
K
G
T
M
T
L
Site 19
T81
T
Y
P
K
G
T
M
T
L
G
R
A
T
N
R
Site 20
T86
T
M
T
L
G
R
A
T
N
R
A
V
Y
G
G
Site 21
Y91
R
A
T
N
R
A
V
Y
G
G
R
V
T
A
M
Site 22
T96
A
V
Y
G
G
R
V
T
A
M
G
S
S
P
N
Site 23
S101
R
V
T
A
M
G
S
S
P
N
I
A
S
A
G
Site 24
S106
G
S
S
P
N
I
A
S
A
G
L
S
H
T
D
Site 25
T112
A
S
A
G
L
S
H
T
D
V
L
S
Y
T
D
Site 26
S116
L
S
H
T
D
V
L
S
Y
T
D
Q
H
G
G
Site 27
Y117
S
H
T
D
V
L
S
Y
T
D
Q
H
G
G
L
Site 28
T118
H
T
D
V
L
S
Y
T
D
Q
H
G
G
L
T
Site 29
T125
T
D
Q
H
G
G
L
T
G
S
S
H
H
H
H
Site 30
S145
M
L
R
Q
V
R
D
S
T
M
L
D
L
Q
A
Site 31
T146
L
R
Q
V
R
D
S
T
M
L
D
L
Q
A
Q
Site 32
S173
K
E
L
D
I
K
D
S
K
L
G
S
S
M
N
Site 33
S177
I
K
D
S
K
L
G
S
S
M
N
S
I
K
T
Site 34
S178
K
D
S
K
L
G
S
S
M
N
S
I
K
T
F
Site 35
S181
K
L
G
S
S
M
N
S
I
K
T
F
W
S
P
Site 36
T184
S
S
M
N
S
I
K
T
F
W
S
P
E
L
K
Site 37
S187
N
S
I
K
T
F
W
S
P
E
L
K
K
E
R
Site 38
S205
K
E
E
A
A
R
M
S
V
L
K
E
Q
M
R
Site 39
S214
L
K
E
Q
M
R
V
S
H
E
E
N
Q
H
L
Site 40
T234
A
L
Q
D
E
L
R
T
Q
R
D
L
N
H
L
Site 41
S246
N
H
L
L
Q
Q
E
S
G
N
R
G
A
E
H
Site 42
T259
E
H
F
T
I
E
L
T
E
E
N
F
R
R
L
Site 43
T283
E
L
F
L
L
R
K
T
L
E
E
M
E
L
R
Site 44
T293
E
M
E
L
R
I
E
T
Q
K
Q
T
L
N
A
Site 45
S304
T
L
N
A
R
D
E
S
I
K
K
L
L
E
M
Site 46
S314
K
L
L
E
M
L
Q
S
K
G
L
P
S
K
S
Site 47
S319
L
Q
S
K
G
L
P
S
K
S
L
E
D
D
N
Site 48
S321
S
K
G
L
P
S
K
S
L
E
D
D
N
E
R
Site 49
S337
R
R
M
A
E
A
E
S
Q
V
S
H
L
E
V
Site 50
S340
A
E
A
E
S
Q
V
S
H
L
E
V
I
L
D
Site 51
S364
R
E
E
L
H
R
R
S
Q
L
Q
P
E
P
A
Site 52
T373
L
Q
P
E
P
A
K
T
K
A
L
Q
T
V
I
Site 53
T385
T
V
I
E
M
K
D
T
K
I
A
S
L
E
R
Site 54
S389
M
K
D
T
K
I
A
S
L
E
R
N
I
R
D
Site 55
Y425
E
I
K
Q
I
E
V
Y
K
S
H
S
K
F
M
Site 56
T434
S
H
S
K
F
M
K
T
K
I
D
Q
L
K
Q
Site 57
S444
D
Q
L
K
Q
E
L
S
K
K
E
S
E
L
L
Site 58
S448
Q
E
L
S
K
K
E
S
E
L
L
A
L
Q
T
Site 59
S461
Q
T
K
L
E
T
L
S
N
Q
N
S
D
C
K
Site 60
S465
E
T
L
S
N
Q
N
S
D
C
K
Q
H
I
E
Site 61
S477
H
I
E
V
L
K
E
S
L
T
A
K
E
Q
R
Site 62
S504
L
R
L
E
E
K
E
S
F
L
N
K
K
T
K
Site 63
T517
T
K
Q
L
Q
D
L
T
E
E
K
G
T
L
A
Site 64
T522
D
L
T
E
E
K
G
T
L
A
G
E
I
R
D
Site 65
S571
N
L
K
D
R
V
K
S
L
Q
T
D
S
S
N
Site 66
S576
V
K
S
L
Q
T
D
S
S
N
T
D
T
A
L
Site 67
S577
K
S
L
Q
T
D
S
S
N
T
D
T
A
L
A
Site 68
T581
T
D
S
S
N
T
D
T
A
L
A
T
L
E
E
Site 69
S591
A
T
L
E
E
A
L
S
E
K
E
R
I
I
E
Site 70
S617
E
R
L
E
E
I
E
S
F
R
K
E
N
K
D
Site 71
T637
N
A
L
Q
A
E
L
T
E
K
E
S
S
L
I
Site 72
S642
E
L
T
E
K
E
S
S
L
I
D
L
K
E
H
Site 73
S652
D
L
K
E
H
A
S
S
L
A
S
A
G
L
K
Site 74
S655
E
H
A
S
S
L
A
S
A
G
L
K
R
D
S
Site 75
S662
S
A
G
L
K
R
D
S
K
L
K
S
L
E
I
Site 76
S666
K
R
D
S
K
L
K
S
L
E
I
A
I
E
Q
Site 77
S713
K
Q
L
D
K
E
A
S
Y
Y
R
D
E
C
G
Site 78
Y714
Q
L
D
K
E
A
S
Y
Y
R
D
E
C
G
K
Site 79
Y715
L
D
K
E
A
S
Y
Y
R
D
E
C
G
K
A
Site 80
T754
I
A
E
L
E
S
L
T
L
R
H
M
K
D
Q
Site 81
S792
E
V
R
R
R
E
D
S
M
A
D
N
S
Q
H
Site 82
S797
E
D
S
M
A
D
N
S
Q
H
L
Q
I
E
E
Site 83
T819
T
R
Q
E
L
D
A
T
K
A
R
L
A
S
T
Site 84
S825
A
T
K
A
R
L
A
S
T
Q
Q
S
L
A
E
Site 85
S829
R
L
A
S
T
Q
Q
S
L
A
E
K
E
A
H
Site 86
S876
N
I
A
L
L
E
L
S
A
S
K
K
K
K
T
Site 87
S878
A
L
L
E
L
S
A
S
K
K
K
K
T
Q
E
Site 88
T883
S
A
S
K
K
K
K
T
Q
E
E
V
M
A
L
Site 89
S934
H
H
H
H
H
H
R
S
P
G
R
S
Q
H
S
Site 90
S938
H
H
R
S
P
G
R
S
Q
H
S
N
H
R
P
Site 91
S941
S
P
G
R
S
Q
H
S
N
H
R
P
S
P
D
Site 92
S946
Q
H
S
N
H
R
P
S
P
D
Q
D
D
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation