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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CEP290
Full Name:
Centrosomal protein of 290 kDa
Alias:
3H11Ag; BBS14; Cancer/testis antigen 87; CE290; Centrosomal protein 290kDa; Centrosomal protein Cep290; CT87; CTCL tumor antigen se2-2; FLJ13615; JBTS5; JBTS6; Joubert syndrome 5; KIAA0373; LCA10; MKS4; Nephrocystin-6; NPHP6; Rd16; SLSN6; Tumor antigen se2-2
Type:
Mass (Da):
290386
Number AA:
2479
UniProt ID:
O15078
International Prot ID:
IPI00784201
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0030030
GO:0042462
GO:0030902
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
V
E
V
N
E
L
K
S
E
K
Q
E
N
V
I
Site 2
T89
K
F
E
N
Q
L
K
T
K
V
M
K
L
E
N
Site 3
T110
Q
S
A
G
G
R
D
T
R
F
L
R
N
E
I
Site 4
S160
E
E
A
E
N
E
N
S
K
L
R
R
E
N
K
Site 5
Y183
L
C
Q
D
I
I
D
Y
Q
K
Q
I
D
S
Q
Site 6
S189
D
Y
Q
K
Q
I
D
S
Q
K
E
T
L
L
S
Site 7
T193
Q
I
D
S
Q
K
E
T
L
L
S
R
R
G
E
Site 8
S196
S
Q
K
E
T
L
L
S
R
R
G
E
D
S
D
Site 9
S202
L
S
R
R
G
E
D
S
D
Y
R
S
Q
L
S
Site 10
Y204
R
R
G
E
D
S
D
Y
R
S
Q
L
S
K
K
Site 11
S206
G
E
D
S
D
Y
R
S
Q
L
S
K
K
N
Y
Site 12
Y213
S
Q
L
S
K
K
N
Y
E
L
I
Q
Y
L
D
Site 13
Y218
K
N
Y
E
L
I
Q
Y
L
D
E
I
Q
T
L
Site 14
S246
M
R
K
N
L
E
E
S
V
Q
E
M
E
K
M
Site 15
Y257
M
E
K
M
T
D
E
Y
N
R
M
K
A
I
V
Site 16
Y281
L
K
K
E
N
D
H
Y
Q
L
Q
V
Q
E
L
Site 17
S294
E
L
T
D
L
L
K
S
K
N
E
E
D
D
P
Site 18
S318
E
E
W
K
L
I
L
S
S
K
D
D
E
I
I
Site 19
S319
E
W
K
L
I
L
S
S
K
D
D
E
I
I
E
Site 20
Y327
K
D
D
E
I
I
E
Y
Q
Q
M
L
H
N
L
Site 21
S348
A
Q
L
D
A
D
K
S
N
V
M
A
L
Q
Q
Site 22
S362
Q
G
I
Q
E
R
D
S
Q
I
K
M
L
T
E
Site 23
S399
L
Q
R
N
K
G
A
S
T
L
S
Q
Q
T
H
Site 24
T400
Q
R
N
K
G
A
S
T
L
S
Q
Q
T
H
M
Site 25
S402
N
K
G
A
S
T
L
S
Q
Q
T
H
M
K
I
Site 26
T426
K
T
K
E
A
E
R
T
A
E
L
A
E
A
D
Site 27
Y451
A
L
K
R
L
K
D
Y
E
S
G
V
Y
G
L
Site 28
S453
K
R
L
K
D
Y
E
S
G
V
Y
G
L
E
D
Site 29
Y456
K
D
Y
E
S
G
V
Y
G
L
E
D
A
V
V
Site 30
S494
N
K
L
E
L
K
I
S
D
F
L
D
E
N
E
Site 31
T513
R
V
G
L
E
P
K
T
M
I
D
L
T
E
F
Site 32
T518
P
K
T
M
I
D
L
T
E
F
R
N
S
K
H
Site 33
S523
D
L
T
E
F
R
N
S
K
H
L
K
Q
Q
Q
Site 34
S544
I
L
L
K
E
I
E
S
L
E
E
E
R
L
D
Site 35
T569
E
R
G
K
R
S
A
T
S
G
L
T
T
E
D
Site 36
T574
S
A
T
S
G
L
T
T
E
D
L
N
L
T
E
Site 37
T580
T
T
E
D
L
N
L
T
E
N
I
S
Q
G
D
Site 38
S584
L
N
L
T
E
N
I
S
Q
G
D
R
I
S
E
Site 39
S590
I
S
Q
G
D
R
I
S
E
R
K
L
D
L
L
Site 40
S598
E
R
K
L
D
L
L
S
L
K
N
M
S
E
A
Site 41
S603
L
L
S
L
K
N
M
S
E
A
Q
S
K
N
E
Site 42
S607
K
N
M
S
E
A
Q
S
K
N
E
F
L
S
R
Site 43
S626
K
E
R
D
L
E
R
S
R
T
V
I
A
K
F
Site 44
T628
R
D
L
E
R
S
R
T
V
I
A
K
F
Q
N
Site 45
S673
D
V
K
G
G
E
T
S
L
I
I
P
S
L
E
Site 46
T709
K
A
Q
V
D
Q
L
T
G
R
N
E
E
L
R
Site 47
S722
L
R
Q
E
L
R
E
S
R
K
E
A
I
N
Y
Site 48
Y729
S
R
K
E
A
I
N
Y
S
Q
Q
L
A
K
A
Site 49
S730
R
K
E
A
I
N
Y
S
Q
Q
L
A
K
A
N
Site 50
S748
D
H
L
E
K
E
T
S
L
L
R
Q
S
E
G
Site 51
S753
E
T
S
L
L
R
Q
S
E
G
S
N
V
V
F
Site 52
S756
L
L
R
Q
S
E
G
S
N
V
V
F
K
G
I
Site 53
S773
P
D
G
I
A
P
S
S
A
S
I
I
N
S
Q
Site 54
S775
G
I
A
P
S
S
A
S
I
I
N
S
Q
N
E
Site 55
S779
S
S
A
S
I
I
N
S
Q
N
E
Y
L
I
H
Site 56
Y783
I
I
N
S
Q
N
E
Y
L
I
H
L
L
Q
E
Site 57
S804
K
L
K
N
L
E
D
S
L
E
D
Y
N
R
K
Site 58
Y808
L
E
D
S
L
E
D
Y
N
R
K
F
A
V
I
Site 59
Y823
R
H
Q
Q
S
L
L
Y
K
E
Y
L
S
E
K
Site 60
Y826
Q
S
L
L
Y
K
E
Y
L
S
E
K
E
T
W
Site 61
T832
E
Y
L
S
E
K
E
T
W
K
T
E
S
K
T
Site 62
T835
S
E
K
E
T
W
K
T
E
S
K
T
I
K
E
Site 63
Y861
D
A
I
K
V
K
E
Y
N
N
L
L
N
A
L
Site 64
S872
L
N
A
L
Q
M
D
S
D
E
M
K
K
I
L
Site 65
S883
K
K
I
L
A
E
N
S
R
K
I
T
V
L
Q
Site 66
T887
A
E
N
S
R
K
I
T
V
L
Q
V
N
E
K
Site 67
S895
V
L
Q
V
N
E
K
S
L
I
R
Q
Y
T
T
Site 68
Y900
E
K
S
L
I
R
Q
Y
T
T
L
V
E
L
E
Site 69
T901
K
S
L
I
R
Q
Y
T
T
L
V
E
L
E
R
Site 70
T902
S
L
I
R
Q
Y
T
T
L
V
E
L
E
R
Q
Site 71
S923
K
Q
K
N
E
L
L
S
M
E
A
E
V
C
E
Site 72
S956
L
Q
K
V
V
D
N
S
V
S
L
S
E
L
E
Site 73
S960
V
D
N
S
V
S
L
S
E
L
E
L
A
N
K
Site 74
S991
N
M
L
V
Q
R
T
S
N
L
E
H
L
E
C
Site 75
S1009
S
L
K
E
Q
V
E
S
I
N
K
E
L
E
I
Site 76
T1017
I
N
K
E
L
E
I
T
K
E
K
L
H
T
I
Site 77
T1023
I
T
K
E
K
L
H
T
I
E
Q
A
W
E
Q
Site 78
S1039
T
K
L
G
N
E
S
S
M
D
K
A
K
K
S
Site 79
S1046
S
M
D
K
A
K
K
S
I
T
N
S
D
I
V
Site 80
T1048
D
K
A
K
K
S
I
T
N
S
D
I
V
S
I
Site 81
S1050
A
K
K
S
I
T
N
S
D
I
V
S
I
S
K
Site 82
Y1080
A
E
H
C
Q
K
M
Y
E
H
L
R
T
S
L
Site 83
T1085
K
M
Y
E
H
L
R
T
S
L
K
Q
M
E
E
Site 84
S1086
M
Y
E
H
L
R
T
S
L
K
Q
M
E
E
R
Site 85
S1125
L
R
D
E
L
A
D
S
V
S
K
A
V
S
D
Site 86
S1127
D
E
L
A
D
S
V
S
K
A
V
S
D
A
D
Site 87
S1131
D
S
V
S
K
A
V
S
D
A
D
R
Q
R
I
Site 88
S1153
M
E
L
K
V
E
V
S
K
L
R
E
I
S
D
Site 89
S1159
V
S
K
L
R
E
I
S
D
I
A
R
R
Q
V
Site 90
S1182
S
R
D
K
E
V
E
S
L
R
M
Q
L
L
D
Site 91
Y1190
L
R
M
Q
L
L
D
Y
Q
A
Q
S
D
E
K
Site 92
S1194
L
L
D
Y
Q
A
Q
S
D
E
K
S
L
I
A
Site 93
S1198
Q
A
Q
S
D
E
K
S
L
I
A
K
L
H
Q
Site 94
S1209
K
L
H
Q
H
N
V
S
L
Q
L
S
E
A
T
Site 95
S1213
H
N
V
S
L
Q
L
S
E
A
T
A
L
G
K
Site 96
S1223
T
A
L
G
K
L
E
S
I
T
S
K
L
Q
K
Site 97
S1226
G
K
L
E
S
I
T
S
K
L
Q
K
M
E
A
Site 98
Y1250
D
E
K
E
Q
A
L
Y
Y
A
R
L
E
G
R
Site 99
Y1251
E
K
E
Q
A
L
Y
Y
A
R
L
E
G
R
N
Site 100
T1266
R
A
K
H
L
R
Q
T
I
Q
S
L
R
R
Q
Site 101
S1269
H
L
R
Q
T
I
Q
S
L
R
R
Q
F
S
G
Site 102
S1275
Q
S
L
R
R
Q
F
S
G
A
L
P
L
A
Q
Site 103
T1289
Q
Q
E
K
F
S
K
T
M
I
Q
L
Q
N
D
Site 104
T1318
H
R
N
M
E
N
K
T
L
E
M
E
L
K
L
Site 105
S1333
K
G
L
E
E
L
I
S
T
L
K
D
T
K
G
Site 106
T1334
G
L
E
E
L
I
S
T
L
K
D
T
K
G
A
Site 107
Y1374
K
D
K
E
E
I
K
Y
L
N
N
I
I
S
E
Site 108
S1380
K
Y
L
N
N
I
I
S
E
Y
E
R
T
I
S
Site 109
Y1382
L
N
N
I
I
S
E
Y
E
R
T
I
S
S
L
Site 110
T1385
I
I
S
E
Y
E
R
T
I
S
S
L
E
E
E
Site 111
S1387
S
E
Y
E
R
T
I
S
S
L
E
E
E
I
V
Site 112
S1388
E
Y
E
R
T
I
S
S
L
E
E
E
I
V
Q
Site 113
S1441
K
F
E
E
A
T
G
S
I
P
D
P
S
L
P
Site 114
S1446
T
G
S
I
P
D
P
S
L
P
L
P
N
Q
L
Site 115
T1473
I
I
L
E
T
R
A
T
C
K
S
L
E
E
K
Site 116
S1476
E
T
R
A
T
C
K
S
L
E
E
K
L
K
E
Site 117
S1486
E
K
L
K
E
K
E
S
A
L
R
L
A
E
Q
Site 118
S1497
L
A
E
Q
N
I
L
S
R
D
K
V
I
N
E
Site 119
T1512
L
R
L
R
L
P
A
T
A
E
R
E
K
L
I
Site 120
S1531
R
K
E
M
E
P
K
S
H
H
T
L
K
I
A
Site 121
Y1559
K
E
E
V
L
K
K
Y
Q
R
L
L
E
K
A
Site 122
S1595
L
E
L
Q
A
D
S
S
L
N
K
F
K
Q
T
Site 123
S1610
A
W
D
L
M
K
Q
S
P
T
P
V
P
T
N
Site 124
T1612
D
L
M
K
Q
S
P
T
P
V
P
T
N
K
H
Site 125
T1629
R
L
A
E
M
E
Q
T
V
A
E
Q
D
D
S
Site 126
S1636
T
V
A
E
Q
D
D
S
L
S
S
L
L
V
K
Site 127
S1638
A
E
Q
D
D
S
L
S
S
L
L
V
K
L
K
Site 128
S1639
E
Q
D
D
S
L
S
S
L
L
V
K
L
K
K
Site 129
T1658
L
E
R
Q
R
E
I
T
E
L
K
V
K
E
F
Site 130
Y1692
A
E
V
E
D
L
K
Y
L
L
D
Q
S
Q
K
Site 131
S1697
L
K
Y
L
L
D
Q
S
Q
K
E
S
Q
C
L
Site 132
S1701
L
D
Q
S
Q
K
E
S
Q
C
L
K
S
E
L
Site 133
T1720
E
A
N
S
R
A
P
T
T
T
M
R
N
L
V
Site 134
T1721
A
N
S
R
A
P
T
T
T
M
R
N
L
V
E
Site 135
T1722
N
S
R
A
P
T
T
T
M
R
N
L
V
E
R
Site 136
S1732
N
L
V
E
R
L
K
S
Q
L
A
L
K
E
K
Site 137
S1765
A
A
E
E
R
I
I
S
A
T
S
Q
K
E
A
Site 138
T1767
E
E
R
I
I
S
A
T
S
Q
K
E
A
H
L
Site 139
T1784
Q
Q
I
V
D
R
H
T
R
E
L
K
T
Q
V
Site 140
T1789
R
H
T
R
E
L
K
T
Q
V
E
D
L
N
E
Site 141
T1807
K
L
K
E
A
L
K
T
S
K
N
R
E
N
S
Site 142
S1808
L
K
E
A
L
K
T
S
K
N
R
E
N
S
L
Site 143
S1814
T
S
K
N
R
E
N
S
L
T
D
N
L
N
D
Site 144
T1816
K
N
R
E
N
S
L
T
D
N
L
N
D
L
N
Site 145
T1858
K
R
Q
I
K
R
L
T
S
G
L
Q
G
K
P
Site 146
S1859
R
Q
I
K
R
L
T
S
G
L
Q
G
K
P
L
Site 147
T1867
G
L
Q
G
K
P
L
T
D
N
K
Q
S
L
I
Site 148
T1940
E
G
E
V
F
T
L
T
K
Q
L
N
T
L
K
Site 149
T1959
K
A
D
K
E
K
L
T
L
Q
R
K
L
K
T
Site 150
T1966
T
L
Q
R
K
L
K
T
T
G
M
T
V
D
Q
Site 151
T1967
L
Q
R
K
L
K
T
T
G
M
T
V
D
Q
V
Site 152
S1982
L
G
I
R
A
L
E
S
E
K
E
L
E
E
L
Site 153
Y2002
D
L
E
N
D
I
L
Y
M
R
A
H
Q
A
L
Site 154
S2013
H
Q
A
L
P
R
D
S
V
V
E
D
L
H
L
Site 155
Y2024
D
L
H
L
Q
N
R
Y
L
Q
E
K
L
H
A
Site 156
S2037
H
A
L
E
K
Q
F
S
K
D
T
Y
S
K
P
Site 157
T2040
E
K
Q
F
S
K
D
T
Y
S
K
P
S
I
S
Site 158
Y2041
K
Q
F
S
K
D
T
Y
S
K
P
S
I
S
G
Site 159
S2042
Q
F
S
K
D
T
Y
S
K
P
S
I
S
G
I
Site 160
S2045
K
D
T
Y
S
K
P
S
I
S
G
I
E
S
D
Site 161
S2047
T
Y
S
K
P
S
I
S
G
I
E
S
D
D
H
Site 162
S2051
P
S
I
S
G
I
E
S
D
D
H
C
Q
R
E
Site 163
S2070
K
E
N
L
K
L
S
S
E
N
I
E
L
K
F
Site 164
S2120
K
L
G
H
V
R
G
S
G
R
S
G
K
T
I
Site 165
S2123
H
V
R
G
S
G
R
S
G
K
T
I
P
E
L
Site 166
T2126
G
S
G
R
S
G
K
T
I
P
E
L
E
K
T
Site 167
T2159
K
K
A
S
G
I
L
T
S
E
K
M
A
N
I
Site 168
S2189
A
H
L
G
H
Q
L
S
M
H
Y
E
S
K
T
Site 169
T2238
E
I
L
N
E
K
M
T
V
Q
L
E
E
T
G
Site 170
S2253
K
R
L
Q
F
A
E
S
R
G
P
Q
L
E
G
Site 171
S2263
P
Q
L
E
G
A
D
S
K
S
W
K
S
I
V
Site 172
S2265
L
E
G
A
D
S
K
S
W
K
S
I
V
V
T
Site 173
S2268
A
D
S
K
S
W
K
S
I
V
V
T
R
M
Y
Site 174
T2272
S
W
K
S
I
V
V
T
R
M
Y
E
T
K
L
Site 175
Y2275
S
I
V
V
T
R
M
Y
E
T
K
L
K
E
L
Site 176
T2284
T
K
L
K
E
L
E
T
D
I
A
K
K
N
Q
Site 177
T2294
A
K
K
N
Q
S
I
T
D
L
K
Q
L
V
K
Site 178
T2304
K
Q
L
V
K
E
A
T
E
R
E
Q
K
V
N
Site 179
Y2313
R
E
Q
K
V
N
K
Y
N
E
D
L
E
Q
Q
Site 180
T2333
H
V
P
E
G
A
E
T
E
Q
G
L
K
R
E
Site 181
S2369
I
E
A
N
K
D
Q
S
G
A
E
S
T
I
P
Site 182
S2373
K
D
Q
S
G
A
E
S
T
I
P
D
A
D
Q
Site 183
T2390
E
K
I
K
D
L
E
T
Q
L
K
M
S
D
L
Site 184
S2395
L
E
T
Q
L
K
M
S
D
L
E
K
Q
H
L
Site 185
S2419
E
L
E
N
F
D
P
S
F
F
E
E
I
E
D
Site 186
Y2429
E
E
I
E
D
L
K
Y
N
Y
K
E
E
V
K
Site 187
S2458
Q
L
G
V
E
L
T
S
P
V
A
A
S
E
E
Site 188
S2472
E
F
E
D
E
E
E
S
P
V
N
F
P
I
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation